prajmaline and Granuloma

Nine patients are reported who developed hepatic injury following the administration of therapeutic agents. The drugs incriminated were prajmalium bitartrate (4 patients), quinidine (3 patients), procainamide and nifedipine (one patient each). In all patients the clinical features indicated an allergic process, which in three cases was substantiated by positive response to reexposure. The detection of immunologic processes in our patients by various in vitro methods supports the assumption that immune mechanisms may be involved in the production of drug-induced hepatic disease and confirm allergy.

Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fluorescent Antibody Technique; Granuloma; Humans; Immunoglobulin A; Immunoglobulin G; Liver; Male; Microscopy, Electron; Middle Aged; Nifedipine; Prajmaline; Procainamide; Quinidine