pradefovir-mesylate and Hepatitis-B

pradefovir-mesylate has been researched along with Hepatitis-B* in 1 studies

Reviews

1 review(s) available for pradefovir-mesylate and Hepatitis-B

Article	Year
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver. Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:2 HepDirect prodrugs represent a novel class of cytochrome P450-activated prodrugs capable of targeting certain drugs to the liver. In this review, the HepDirect prodrug concept and its use for the delivery of nucleotides to the liver for the treatment of viral hepatitis is summarized. Preclinical and clinical data for the most advanced HepDirect prodrug, pradefovir, highlight the liver-targeting capability of these prodrugs, and the potential benefit of liver targeting on drug efficacy, safety and viral resistance. Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Haplorhini; Hepatitis B; Humans; Liver; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphotransferases; Prodrugs; Randomized Controlled Trials as Topic; Rats	2006

Article

Year

HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.

Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:2

HepDirect prodrugs represent a novel class of cytochrome P450-activated prodrugs capable of targeting certain drugs to the liver. In this review, the HepDirect prodrug concept and its use for the delivery of nucleotides to the liver for the treatment of viral hepatitis is summarized. Preclinical and clinical data for the most advanced HepDirect prodrug, pradefovir, highlight the liver-targeting capability of these prodrugs, and the potential benefit of liver targeting on drug efficacy, safety and viral resistance.

Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Haplorhini; Hepatitis B; Humans; Liver; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphotransferases; Prodrugs; Randomized Controlled Trials as Topic; Rats

2006