practolol and Eye Diseases studies

Practolol: A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
practolol : N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.

Research Excerpts

Excerpt	Relevance	Reference
"The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome."	7.66	Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. ( Amos, HE; Artis, J; Lake, BG, 1978)
"Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol."	7.65	Untoward effects associated with practolol administration: oculomucocutaneous syndrome. ( Wright, P, 1975)
" The results for practolol, withdrawn due to the associated oculomucocutaneous syndrome, are given as a single worked example."	3.73	A ranked presentation of the MHRA/CSM (Medicines & Health Care Regulatory Agency/Committee on Safety of Medicines) Drug Analysis Print (DAP) data on practolol. ( Mann, RD, 2005)
"The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome."	3.66	Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. ( Amos, HE; Artis, J; Lake, BG, 1978)
"Recognition of the "occulomucocutaneous syndrome" related to practolol administration has caused the safety of other beta-blocking agents to come under close scrutiny."	3.65	Practolol and the safety of other beta blockers. ( Sutherland, DC; Wilson, JD, 1976)
"Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol."	3.65	Untoward effects associated with practolol administration: oculomucocutaneous syndrome. ( Wright, P, 1975)
"The possible adverse effects of treatment during pregnancy are also considered."	2.36	Beta-adrenoceptor blocking drugs: adverse reactions and drug interactions. ( Beeley, L; Kendall, MJ, 1983)
"Serological studies in 22 patients presenting with ocular disease attributable to dosage with the beta-blocking agent practolol revealed a raised incidence of antinuclear antibodies."	1.26	Practolol and ocular toxicity. Antibodies in serum and tears. ( Garner, A; Rahi, AH, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (97.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (2.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mann, RD	1
Vogel, R	1
Kendall, MJ	1
Beeley, L	1
Slezak, H	1
Liotet, S	1
N'Guyen, H	1
Boissin, JP	1
Fraunfelder, FT	2
Wall-Manning, HJ	1
Erikssen, J	1
Sutherland, DC	1
Wilson, JD	1
Frishman, W	1
Silverman, R	1
Strom, J	1
Elkayam, U	1
Sonnenblick, E	1
Behan, PO	1
Behan, WM	1
Zacharias, FJ	2
Nicholls, JT	3
Amos, HE	3
Brigden, WD	3
Dick, HM	1
Wright, P	4
Chapman, CM	2
Holt, PJ	1
Waddington, E	1
Kauppinen, K	1
Niemi, KM	1
Salo, OP	1
Ahonen, A	1
Jachuck, SJ	1
Stephenson, J	1
Bird, T	1
Jackson, FS	1
Clark, F	1
Lake, BG	1
Artis, J	1
Lyall, JR	1
Crews, SJ	1
Cruysberg, JR	1
Pinckers, A	1
Rahi, AH	2
Garner, A	2
Despopoulos, A	1
Maurice, PN	1
Almeyda, J	1
Wolter-Czerwińska, H	1
Filipowicz-Banachowa, AF	1
McKerron, RA	1
Farr, MJ	1
Wingate, JP	1
Shaw, JN	1
Galbraith, JE	1
Lunde, I	1
Borchgrevink, CF	1
Marghescu, S	1
Taylor, F	1
Proctor, CR	1

Article	Year
Beta-adrenoceptor blocking drugs and the eye. Journal of clinical and hospital pharmacy, 1983, Volume: 8, Issue:2 Topics: Adrenergic beta-Antagonists; Eye Diseases; Glaucoma; Humans; Practolol	1983
Beta-adrenoceptor blocking drugs: adverse reactions and drug interactions. Pharmacology & therapeutics, 1983, Volume: 21, Issue:3 Topics: Adrenergic beta-Antagonists; Bradycardia; Brain; Drug Eruptions; Drug Interactions; Eye Diseases; Fe	1983

Article	Year
A ranked presentation of the MHRA/CSM (Medicines & Health Care Regulatory Agency/Committee on Safety of Medicines) Drug Analysis Print (DAP) data on practolol. Pharmacoepidemiology and drug safety, 2005, Volume: 14, Issue:10 Topics: Adrenergic beta-Antagonists; Adverse Drug Reaction Reporting Systems; Consumer Product Safety; Eye D	2005
[Drug-induced eye lesions in the aged]. Aktuelle Gerontologie, 1983, Volume: 13, Issue:5 Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases	1983
[Ocular toxicity of practolol: study of lacrimal proteins apropos of a case we were permitted to observe]. Bulletin des societes d'ophtalmologie de France, 1981, Volume: 81, Issue:2 Topics: Aged; Eye Diseases; Eye Proteins; Humans; Male; Practolol; Tears	1981
Interim report: National Registry of possible Drug-induced Ocular Side Effects. Ophthalmology, 1980, Volume: 87, Issue:2 Topics: Contact Lenses; Drug-Related Side Effects and Adverse Reactions; Eye Diseases; Fluorouracil; Humans;	1980
Problems with practolol. Drugs, 1975, Volume: 10, Issue:5-6 Topics: Adrenergic beta-Antagonists; Cross Reactions; Eye Diseases; Heart Diseases; Humans; Peritonitis; Pra	1975
Editorial: Beta-blockers and the eye. The British journal of ophthalmology, 1976, Volume: 60, Issue:5 Topics: Adrenergic beta-Antagonists; Eye; Eye Diseases; Humans; Practolol	1976
[Oculocutaneous reactions following treatment with betablockers]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Aug-30, Volume: 96, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Eruptions; Eye Diseases; Humans; Practolol	1976
Practolol and the safety of other beta blockers. The New Zealand medical journal, 1976, Oct-13, Volume: 84, Issue:573 Topics: Adrenergic beta-Antagonists; Aged; Antibodies, Antinuclear; Drug Eruptions; Eye Diseases; Female; Hu	1976
Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 4. Adverse effects. Choosing a beta-adrenoreceptor blocker. American heart journal, 1979, Volume: 98, Issue:2 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bronchi; Central Nervous System Diseases; Deafnes	1979
Immunological abnormalities in patients who had the oculomucocutaneous syndrome associated with practolol therapy. Lancet (London, England), 1976, Nov-06, Volume: 2, Issue:7993 Topics: Adult; Aged; Autoantibodies; Autoimmune Diseases; Coronary Disease; Drug Eruptions; Eye Diseases; Fe	1976
Immunological changes and practolol. Lancet (London, England), 1976, Dec-11, Volume: 2, Issue:7998 Topics: Eye Diseases; Humans; Lymphocyte Activation; Practolol	1976
Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms. Allergy, 1978, Volume: 33, Issue:2 Topics: Epitopes; Eye Diseases; Gene Frequency; Genes, MHC Class II; HLA Antigens; Humans; Peritonitis; Prac	1978
Editorial: side effects of practolol. British medical journal, 1975, Jun-14, Volume: 2, Issue:5971 Topics: Dermatitis, Exfoliative; Eye Diseases; Humans; Keratoderma, Palmoplantar; Lupus Erythematosus, Syste	1975
[Actual late effects. Skin, eye and hearing changes during treatment with practolol (Eraldin)]. Ugeskrift for laeger, 1975, Apr-28, Volume: 137, Issue:18 Topics: Drug Eruptions; Eye Diseases; Hearing Disorders; Humans; Practolol	1975
Oculocutaneous reaction to oxprenolol. British medical journal, 1975, Jun-07, Volume: 2, Issue:5970 Topics: Aged; Biopsy; Drug Eruptions; Eye Diseases; Heart Diseases; Humans; Oxprenolol; Practolol	1975
Adverse effects of practolol. Annals of clinical research, 1976, Volume: 8, Issue:4 Topics: Drug Eruptions; Drug Evaluation; Eye Diseases; Humans; Practolol	1976
Cutaneous reactions to practolol. Clinical and histopathological study. Annals of clinical research, 1976, Volume: 8, Issue:4 Topics: Administration, Oral; Aged; Dose-Response Relationship, Drug; Drug Eruptions; Eye Diseases; Female;	1976
[Adverse effects of practolol]. Duodecim; laaketieteellinen aikakauskirja, 1976, Volume: 92, Issue:22 Topics: Drug Eruptions; Eye Diseases; Humans; Practolol	1976
Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. British medical journal, 1978, Feb-18, Volume: 1, Issue:6110 Topics: Antibodies; Antibody Specificity; Drug Eruptions; Eye Diseases; Humans; Mucous Membrane; Practolol;	1978
Letter: Ocular reactions to beta-blockers. British medical journal, 1975, Jun-28, Volume: 2, Issue:5973 Topics: Adrenergic beta-Antagonists; Cornea; Eye Diseases; Humans; Male; Middle Aged; Oxprenolol; Practolol	1975
What's new in ocular toxicology? The Sight-saving review, 1978,Summer, Volume: 48, Issue:2 Topics: Anesthesia, Local; Cannabis; Carbonic Anhydrase Inhibitors; Contraceptives, Oral; Echothiophate Iodi	1978
Ocular adverse reactions to drugs. The Practitioner, 1977, Volume: 219, Issue:1309 Topics: Adrenal Cortex Hormones; Adult; Aged; Amblyopia; Cataract; Chloroquine; Chlorpromazine; Conjunctivit	1977
Ocular disorders resulting from treatment with practolol (Eraldin) [proceedings]. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1977, Volume: 175, Issue:1 Topics: Eye Diseases; Female; Humans; Male; Practolol; Time Factors	1977
Pathology of practolol-induced ocular toxicity. The British journal of ophthalmology, 1976, Volume: 60, Issue:5 Topics: Aged; Angina Pectoris; Conjunctiva; Cornea; Epithelium; Eye; Eye Diseases; Female; Humans; Hypertens	1976
Ocular reaction to oxprenolol. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1976, Aug-14, Volume: 50, Issue:35 Topics: Eye Diseases; Humans; Oxprenolol; Practolol	1976
Adverse reaction to the beta-adrenergic blocking drugs. The British journal of dermatology, 1976, Volume: 95, Issue:3 Topics: Animals; Autoantibodies; Conjunctiva; Eye Diseases; Humans; Lymphocyte Activation; Peritonitis; Prac	1976
[Ocular complications following practolol administration]. Klinika oczna, 1976, Volume: 46, Issue:10 Topics: Eye Diseases; Female; Humans; Light; Middle Aged; Myocardial Infarction; Practolol; Skin Manifestati	1976
Practolol and ocular toxicity. Antibodies in serum and tears. The British journal of ophthalmology, 1976, Volume: 60, Issue:10 Topics: Animals; Antibodies, Antinuclear; Autoantibodies; Eye Diseases; Humans; Immunoglobulin A; Immunoglob	1976
Untoward effects associated with practolol: demonstration of antibody binding to epithelial tissue. British medical journal, 1975, Mar-15, Volume: 1, Issue:5958 Topics: Animals; Antibodies; Antibody Specificity; Binding Sites, Antibody; Conjunctivitis; Epithelial Cells	1975
Untoward effects associated with practolol administration: oculomucocutaneous syndrome. British medical journal, 1975, Mar-15, Volume: 1, Issue:5958 Topics: Adult; Aged; Blindness; Cochlea; Conjunctiva; Ear Diseases; Eye Diseases; Female; Humans; Keratoconj	1975
Practolol and the nephrotic syndrome. British medical journal, 1975, Apr-12, Volume: 2, Issue:5962 Topics: Aged; Angina Pectoris; Eye Diseases; Humans; Lupus Erythematosus, Systemic; Male; Nephrotic Syndrome	1975
Letter: Practolol. The Medical journal of Australia, 1975, May-24, Volume: 1, Issue:21 Topics: Eye Diseases; Female; Humans; Male; Practolol; Tears	1975
[From The committee for the Registration of Adverse Effects. Adverse effects following Eraldin therapy]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1975, Oct-10, Volume: 95, Issue:28 Topics: Eye Diseases; Humans; Practolol; Skin Diseases	1975
[Letter: Skin reactions due to practolol]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1975, Volume: 26, Issue:12 Topics: Angina Pectoris; Eye Diseases; Humans; Practolol; Skin Diseases	1975
Drugs affecting the eye. Australian family physician, 1985, Volume: 14, Issue:8 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Amiodarone; Anti-Inflammatory Agents; Antipsychotic Agen	1985
Letter: Skin reactions to practolol. British medical journal, 1974, Jun-08, Volume: 2, Issue:5918 Topics: Drug Eruptions; Eye Diseases; Humans; Practolol	1974
Letter: Report on adverse reactions associated with practolol. The Medical journal of Australia, 1974, Nov-16, Volume: 2, Issue:20 Topics: Drug Eruptions; Eye Diseases; Hearing Disorders; Humans; Pericarditis; Peritonitis; Practolol	1974

practolol and Eye Diseases

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Research

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