pr-957 has been researched along with Atherosclerosis* in 1 studies
1 other study(ies) available for pr-957 and Atherosclerosis
| Article | Year |
|---|---|
Immunoproteasome subunit β5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice.
The immunoproteasome contains three catalytic subunits (β1i, β2i and β5i) that are important modulators of immune cell homeostasis. A previous study showed a correlation between β5i and human atherosclerotic plaque instability; however, the causative role of β5i in atherosclerosis and the underlying mechanisms remain unknown. Here we explored this issue in apolipoprotein E (Apoe) knockout (eKO) mice with genetic deletion or pharmacological inhibition of β5i. We found that β5i expression was upregulated in lesional macrophages after an atherogenic diet (ATD). β5i/Apoe double KO (dKO) mice fed on the ATD had a significant decrease in both lesion area and necrotic core area, compared with eKO controls. Moreover, dKO mice had less caspase-3 Topics: Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; c-Mer Tyrosine Kinase; Caspase 3; Diet, High-Fat; Macrophages; Mice; Mice, Knockout; NF-kappa B; Oligopeptides; Phagocytosis; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2020 |