pr-957 and Asthma

pr-957 has been researched along with Asthma* in 1 studies

Other Studies

1 other study(ies) available for pr-957 and Asthma

ArticleYear
Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways.
    Clinical science (London, England : 1979), 2018, 08-16, Volume: 132, Issue:15

    Rhinovirus (RV) infection is involved in acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). RV primarily infects upper and lower airway epithelium. Immunoproteasomes (IP) are proteolytic machineries with multiple functions including the regulation of MHC class I antigen processing during viral infection. However, the role of IP in RV infection has not been explored. We sought to investigate the expression and function of IP during airway RV infection. Primary human tracheobronchial epithelial (HTBE) cells were cultured at air-liquid interface (ALI) and treated with RV16, RV1B, or interferon (IFN)-λ in the absence or presence of an IP inhibitor (ONX-0914). IP gene (i.e.

    Topics: Animals; Asthma; Cell Line; Cysteine Endopeptidases; Epithelial Cells; Host-Pathogen Interactions; Humans; Mice, Knockout; Oligopeptides; Picornaviridae Infections; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Respiratory System; Rhinovirus

2018