pq-401 and Hemolysis

pq-401 has been researched along with Hemolysis* in 1 studies

Other Studies

1 other study(ies) available for pq-401 and Hemolysis

Article	Year
The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus. mBio, 2020, 06-30, Volume: 11, Issue:3 Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the presence of legacy antibiotics. Here, we report that the diarylurea derivative PQ401, previously characterized as an inhibitor of the insulin-like growth factor I receptor, kills both antibiotic-resistant and nongrowing antibiotic-tolerant methicillin-resistant Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Drug Synergism; Gentamicins; Hemolysis; Humans; Larva; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Moths; Phenylurea Compounds; Staphylococcal Infections; Staphylococcus aureus	2020

Article

Year

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.

mBio, 2020, 06-30, Volume: 11, Issue:3

Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the presence of legacy antibiotics. Here, we report that the diarylurea derivative PQ401, previously characterized as an inhibitor of the insulin-like growth factor I receptor, kills both antibiotic-resistant and nongrowing antibiotic-tolerant methicillin-resistant

Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Drug Synergism; Gentamicins; Hemolysis; Humans; Larva; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Moths; Phenylurea Compounds; Staphylococcal Infections; Staphylococcus aureus

2020