ppi-2458 has been researched along with Body-Weight* in 1 studies
1 other study(ies) available for ppi-2458 and Body-Weight
Article | Year |
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An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
To elucidate the role of methionine aminopeptidase type-2 (MetAP-2) in the clinical pathology of rheumatoid arthritis, arthritis was induced in rats by administration of peptidoglycan-polysaccharide (PG-PS).. The inhibitor of MetAP-2, PPI-2458, was administered orally at 5 mg/kg every other day during 3 distinct phases of the disease. In vitro studies were performed to clarify in vivo findings.. Ankle swelling was completely alleviated by MetAP-2 inhibition. Inhibition of MetAP-2 in blood and tissues correlated with protection against PG-PS-induced arthritis. Histopathology of the tarsal joints improved following PPI-2458 administration, including a significant improvement of bone structure. In in vitro studies, osteoclast formation and activity were inhibited by PPI-2458, a mechanism not previously attributed to MetAP-2 inhibition.. The important role that MetAP-2 has in the pathophysiological disease processes of PG-PS arthritis provides a strong rationale for evaluating PPI-2458 as a disease modifying antirheumatic treatment for rheumatoid arthritis. Topics: Aminopeptidases; Animals; Arthritis, Rheumatoid; Body Weight; Bone Resorption; Cell Differentiation; Cells, Cultured; Epoxy Compounds; Female; Joints; Metalloendopeptidases; Mice; Osteoclasts; Protease Inhibitors; Rats; Rats, Inbred Lew; Valine | 2008 |