pp36 has been researched along with Hypoxia* in 1 studies
1 other study(ies) available for pp36 and Hypoxia
| Article | Year |
|---|---|
[Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat].
The aim of this study was to investigate how blocking functional endothelin-converting enzyme activity may offer a new approach to inhibition of changes in pulmonary vessels reactivity due to development of hypoxia-induced pulmonary arterial hypertension in rats. This data shows that treatment with endothelin-converting enzyme blocker PP36 significantly reduced pathological changes due to hypoxia-induced pulmonary hypertension. One of the reasons may be the increased production and role of nitric oxide in pulmonary artery tone. Topics: Animals; Aspartic Acid Endopeptidases; Blood Circulation; Deoxyuridine; Dipeptides; Endothelin-1; Endothelin-Converting Enzymes; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Metalloendopeptidases; Nitric Oxide Donors; Nitric Oxide Synthase; Propanolamines; Rats; Rats, Wistar; Succinates | 2008 |