povidone-iodine and Uterine-Cervicitis

The authors report the results achieved in a controlled clinical study carried out for evaluating the efficacy of some topical preparations in the treatment of the so-called non-specific cervicovaginitis. The best results have been observed in 55 patients treated with a 0.1% benzydamine solution, whose efficacy was found to be significantly greater than that of povidone-iodine vaginal suppositories or a 0.2% aluminium acetate solution that were used in an additional 45 patients suffering from non-specific vulvovaginitis and exocervicitis, according to a fully randomized experimental study protocol. The results obtained in the non-selected population of the present study confirm the usefulness of benzydamine vaginal douches in the therapy of non-specific inflammations involving the lower female genital apparatus.

Topics: Acetates; Administration, Intravaginal; Adult; Benzydamine; Double-Blind Method; Female; Humans; Pessaries; Povidone-Iodine; Pyrazoles; Random Allocation; Therapeutic Irrigation; Uterine Cervicitis; Vaginitis

The efficacy of either povidone-iodine (Betadine) or dichloroxylenol (Septocid) intrauterine infusions on the treatment of endometritis and/or cervicitis in cows was examined. One hundred and twelve repeat-breeder Holstein cows (aged 3-7 years) were selected for this study. Rectal and vaginal examinations were applied to detect the signs of endometritis and/or cervicitis. Cows were assigned into two groups: the first group (n = 60) was treated with Betadine solution (0.5%) while the second group (n = 52) was given Septocid (0.1%) administered as intrauterine infusion (100-150 ml). Both treatment were repeated at least two times at 7-day intervals and the cows were rechecked. The responding animals were inseminated 10-12 h after oestrus detection using frozen semen from bulls of proven fertility. The success or failure of treatment was evaluated on the basis of the post-treatment conception rate. The relationship of the body weight of cows, the length of the service period (open days) and the number of previous services with the results of treatment with Betadine or Septocid is discussed. The recovery and conception rates obtained after Betadine treatment were better than those obtained after Septocid. Moreover, healthy cows (> or = 500 kg body weight) and those inseminated before post-partum day 180, having no more than 4-7 previous services, responded well to either Betadine or Septocid treatment.

Topics: Animals; Anti-Infective Agents, Local; Cattle; Cattle Diseases; Chlorophenols; Endometritis; Female; Fertilization; Povidone-Iodine; Treatment Outcome; Uterine Cervicitis