povidone-iodine and Thyroid-Diseases

Povidone-iodine (PVP-I) has been widely used as an antiseptic agent during invasive procedures for prenatal diagnosis. Women have been reported of thyroid dysfunction after simple exposure to PVP-I. We studied the effect on thyroid function and urinary iodine excretion after a single topical application of PVP-I in 31 women who had a miscarriage during the first trimester of pregnancy. PVP-I is absorbed through the skin and the vaginal mucosa, resulting in a sudden increase in the urinary excretion of iodine and a short-term variation in concentrations of thyroid hormones in maternal serum. This metabolic effect could have consequences for the embryo and the fetus during crucial stages of development.

Topics: Abortion, Spontaneous; Anti-Infective Agents, Local; Dilatation and Curettage; Female; Humans; Povidone-Iodine; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Prospective Studies; Thyroid Diseases; Thyrotropin; Thyroxine

Segmental intraluminal instillation of several tumoricidal agents including povidone-iodine has been advocated to prevent anastomotic recurrence after colonic resection for colorectal cancer. The local and systemic effects of on-table whole-colon washout using 5 per cent povidone-iodine were assessed in patients undergoing elective surgery for colorectal cancer.. The local effect of 5 per cent povidone-iodine on the colonic mucosa and the effect of colonic mucosal damage by povidone-iodine on tumour take was first investigated in Fischer 344 rats. In 12 euthyroid non-allergic patients, on-table whole-colon lavage via the appendix was performed. Systemic (thyroid function) and local (mucosal damage assessed by repeat biopsies) effects were studied, as well as the in vitro tumoricidal effect of the final anal effluent on tumour cell suspensions.. After 30 min of contact with povidone-iodine the rat colonic mucosa was severely injured, with detachment of the epithelial cell layer. Povidone-iodine-induced 'colitis' did not result in tumour development after inoculation of 10(6) Mtln3 carcinoma cells in ten rats. Epithelial desquamation was also observed, in all but one patient, 1 and 4 h after colonic lavage. However, epithelial restitution started within 1 day and no abnormality was revealed after 3-7 days. Urinary iodine excretion increased markedly and was not within normal values after 1 week. Levels of thyroid hormones decreased significantly but became normal within 1 week. The anal effluent containing povidone-iodine was found to be tumoricidal in vitro on a human colonic carcinoma cell line and on a tumour cell suspension produced from the patient's tumour.. On-table whole-colon washout using 5 per cent povidone-iodine seems clinically feasible. This technique deserves further study as a substitute for preoperative bowel preparation and may help to prevent recurrent cancer due to implantation of viable exfoliated tumour cells.

Topics: Adult; Aged; Animals; Anti-Infective Agents, Local; Biopsy; Colorectal Neoplasms; Female; Humans; Intestinal Mucosa; Intraoperative Care; Male; Middle Aged; Povidone-Iodine; Rats; Rats, Inbred F344; Therapeutic Irrigation; Thyroid Diseases; Thyronines; Thyrotropin; Thyroxine-Binding Proteins; Tumor Cells, Cultured

Topics: Humans; Infant, Newborn; Ophthalmia Neonatorum; Ophthalmic Solutions; Povidone-Iodine; Thyroid Diseases

Topics: Female; Humans; Iodine; Middle Aged; Povidone; Povidone-Iodine; Thyroid Diseases; Time Factors

Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Iodides; Povidone; Povidone-Iodine; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Thyroid Diseases; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine

Topics: Administration, Topical; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Povidone; Povidone-Iodine; Thyroid Diseases; Thyroid Function Tests; Thyrotropin