povidone-iodine and Skin-Ulcer

Although complete healing may appear to be the logical goal for most patients and clinicians, some wounds do not have the potential to heal due to a number of factors such as inadequate vasculature, coexisting medical conditions and medications that prohibit the healing process. Local management of wounds that are considered to have poor potential for healing remains elusive. The purpose of this article is to review the evidence that supports the use of topical antiseptic agents in non-healable wounds. Retrospective chart audit was conducted to evaluate the use of povidone iodine in the management of wounds that were deemed to have poor healing potential.

Topics: Administration, Topical; Aged; Anti-Infective Agents, Local; Chronic Disease; Female; Humans; Male; Middle Aged; Povidone-Iodine; Retrospective Studies; Skin Ulcer; Wound Healing; Wounds and Injuries

In this investigation the effectiveness was studied of adhesive zinc oxide tape, as additional therapy to the usual application of povidone iodine (10%), for leprosy patients with plantar ulcers in Sulawesi Tengah, Indonesia. The effectiveness (degree of wound healing measured as surface reduction) of this experimental therapy was compared with that of the usual therapy alone. At the same time the influence of the physical activity level on the effectiveness of both therapies was studied. During six weeks 38 leprosy patients with simple ulcers were treated with either one of the therapies. The average wound healing of the experimental group and the control group was 388 mm2 (SD 498) and 260 mm2 (SD 260) respectively. Using the t-test, there was no statistically significant difference in wound healing between the two therapies (p = 1.7). The average wound healing of the experimental group with a high and a low activity level was 342 mm2 (SD 226) and 405 mm2 (SD 571) respectively. The average wound healing of the control group with a high and low activity level was 246 mm2 (SD 289) and 275 mm2 (SD 232) respectively. Using analyses of variance, there was no statistically significant influence on the effectiveness of the therapies (p greater than 0.1). Methodological problems possibly influenced on the results. Different problems which may be encountered during research in third world countries are mentioned.

Topics: Activities of Daily Living; Adult; Female; Humans; Leprosy; Male; Middle Aged; Povidone-Iodine; Skin Ulcer; Wound Healing; Zinc Oxide

In recent years, the number of patients with ischemic skin ulcers due to diabetes mellitus and arteriosclerosis obliterans are increasing. Accordingly, endovascular therapy, drugs, and various wound dressings have been developed and applied to diabetic foot ulcers, and negative-pressure wound therapy, which often requires expensive and burdensome procedures for medical personnel, has also become popular. So simple and minimal invasive home treatment by the patient or their caregiver is required.. The present patient (77 years old, male, Asian) had developed left sole ulcers with draining pus that were resistant to conventional treatment, and he suffered from gait disturbance. We report a case of metatarsal osteomyelitis in a patient with diabetes mellitus and arteriosclerosis obliterans, in whom artificial carbon dioxide foot bathing and povidone-iodine sugar ointment were used continuously to promote bone and joint regeneration, and skin ulcer healing.. A simple therapeutic intervention with artificial carbon dioxide foot bathing and povidone-iodine sugar ointment can improve not only ischemic skin ulcers, but also the bone and joint regeneration of ischemic limbs. This therapy can lead to a reduction in healthcare costs for a huge number of diabetic patients.

Topics: Aged; Arteriosclerosis Obliterans; Carbon Dioxide; Humans; Male; Metatarsal Bones; Ointments; Osteomyelitis; Povidone-Iodine; Skin Ulcer; Sugars

Topics: Chronic Disease; Humans; Hypothyroidism; Ointments; Povidone-Iodine; Skin Ulcer; Sugars; Ulcer

Ulcerative dermatitis (UD) is a common condition in C57BL/6 mice and strains with this background. The etiology of UD is unclear but appears to have a genetic component associated with the C57BL/6 strain and has been reported as secondary to a variety of conditions. Treatment is unrewarding, resulting in euthanasia in many cases. In the present study we compared 3 topical treatments against spontaneous UD in mice with a C57BL/6 background. In total, 301 mice of both sexes were included in this study, and the tested treatments comprised bacitracin-neomycin sulfate-polymixin B sulfate ointment twice daily, 10% povidone-iodine ointment plus 1% silver sulfadiazine cream once daily, and 0.005% sodium hypochlorite once daily. Lesion healing was defined as complete skin reepithelialization with or without hair regrowth. Sex, age, lesion location, and type and length of treatment were analyzed by using univariate and multivariate logistic regression. Of the 79 mice treated with triple-antibiotic ointment, 27 (34%) healed, compared with 43 of the 125 (34%) treated with povidone-iodine and sulfadiazine and 69 of the 97 (71%) treated with hypochlorite. Lesion size and treatment with 0.005% sodium hypochlorite were the only significant predictors of healing; all other variables were not statistically significant in multivariate analysis. We conclude that 0.005% sodium hypochlorite is an effective topical treatment alternative for UD in C57BL/6 mice and strains on this background, and a favorable prognosis depends on the early identification and treatment of those lesions.

Topics: Administration, Topical; Animal Diseases; Animals; Bacitracin; Dermatitis; Drug Combinations; Female; Logistic Models; Male; Mice; Mice, Inbred C57BL; Neomycin; Polymyxin B; Povidone-Iodine; Rodent Diseases; Silver Sulfadiazine; Skin Ulcer; Sodium Hypochlorite; Wound Healing

To investigate the effect of a novel topical wound-healing agent, low-concentration povidone-iodine ointment (LPIO) with a hydrophobic white petrolatum-rich base on skin-wound models in rats and rabbits.. The therapeutic efficacy of topically applied LPIO was compared to that of standard-concentration povidone-iodine ointment (SPIO) and non-treatment control, using a full-thickness skin-wound model in 24 hairless rats and a full-thickness skin-defect model in rabbit earlobes. The animals were kept under standardised conditions at the Central Research Laboratory of Maruishi Pharmaceutical Co. Ltd. (Osaka, Japan). Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations.. LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO.. The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.

Topics: Animals; Anti-Infective Agents, Local; Disease Models, Animal; Ointments; Petrolatum; Povidone-Iodine; Rabbits; Rats; Skin Ulcer; Wound Healing

The topical application of a mixture of sugar and povidone-iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting reepithelialization and granulation tissue formation, as well as by having an anti-microbial effect. In order to clarify the efficacy of a 70% sugar and 3% PI paste (U-PASTA(SP) on infectious skin ulcers, we made a bacterial infection model using methicillin-resistant Staphylococcus aureus (MRSA) on the skin of diabetic db/db mice, and investigated the effect of the paste on the healing process of wounds. Full-thickness wounds were made on the backs of female diabetic mice, (C57BL/ksJ db/db) and inoculated with S. aureus. SP was applied to the closed wounds for 8 days. The degree of repair was evaluated using three histological parameters: The degree of reepithelialization was given a percentage value of 0-100%; the amount of granulation tissue was quantified by measuring the area of granulation (mm(2)); and the number of capillary lumens in the granulation tissue was counted in the complete wound cross-section at 100x magnification. In addition, the colony-forming units (CFU) of MRSA on the wounds were counted. Continuous MRSA infection in the wounds of db/db mice was demonstrated with macroscopic and histopathological images. Wounding and infection caused by MRSA on the back of the diabetic mice significantly induced delayed reepithelialization, granulation tissue formation with inflammatory cell infiltrate and increased CFU on wounds (P < 0.01, respectively) compared to those of the MRSA-infected normal mice. Application of SP significantly accelerated reepithelialization (P < 0.01) and decreased CFU (P < 0.05) of the ulcers in the MRSA-infected wounds, compared to the non-treated group. Histopathological evaluation and CFU on this animal model revealed no significant difference between Methicilin-sensitive Staphylococcus aureus and MRSA infection. These results indicate that wounding on db/db mice provides a useful animal model of bacterial skin infections, and that SP is an effective topical agent for the treatment of diabetic skin ulcers.

Topics: Administration, Cutaneous; Animals; Anti-Infective Agents, Local; Capillaries; Colony Count, Microbial; Diabetes Complications; Disease Models, Animal; Drug Combinations; Epithelial Cells; Female; Granulation Tissue; Methicillin Resistance; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ointments; Povidone-Iodine; Skin Ulcer; Staphylococcal Skin Infections; Staphylococcus aureus; Sucrose; Time Factors; Wound Healing

Povidone-iodine (PVP-I) is generally very safe, but cases of thyroid dysfunction induced by PVP-I have been reported. The effect of long-term treatment with PVP-I on thyroid function was to be assessed. In 40 inpatients of the department of neurology, the status of the use of PVP-I preparations and their effects on serum inorganic iodine levels and thyroid functions were investigated. In 27 patients treated with PVP-I for a long term, inorganic iodine levels were significantly increased as compared to those in 13 patients without PVP-I treatment. Out of 27 patients treated with PVP-I in the long term, subclinical hypothroidism was seen in 3 patients, mild hyperthroidism was seen in 1 patient, and subclinical hyperthyroidism was suspected in 7 patients. Patients treated with PVP-I for a long time should be observed carefully for any manifestation of thyroid dysfunction.

Topics: Amyotrophic Lateral Sclerosis; Anti-Infective Agents, Local; Catheterization, Central Venous; Female; Gastrostomy; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodophors; Longitudinal Studies; Male; Middle Aged; Nasal Mucosa; Parenteral Nutrition; Povidone-Iodine; Safety; Skin Ulcer; Spinocerebellar Degenerations; Thyroid Gland; Thyrotropin; Thyroxine; Tracheotomy; Triiodothyronine; Urethra

Topics: Anti-Infective Agents, Local; Dermatitis, Allergic Contact; Humans; Male; Middle Aged; Patch Tests; Povidone-Iodine; Skin Ulcer

Despite legislation that requires manufacturers to inform the public about the dangers of contact with cement, severe ulceration from cement contact still occurs. We present a retrospective study of seven patients presenting to this department over a 2-year period. All were male and employed in the building trade, their injuries being sustained whilst at work. The injuries were to the lower limb, often multiple and required a median of seven visits before healing was complete. One required hospital admission and skin grafting.

Topics: Accidents, Occupational; Administration, Topical; Adult; Bandages; Construction Materials; Humans; Male; Paraffin; Povidone-Iodine; Product Labeling; Retrospective Studies; Skin Transplantation; Skin Ulcer

There are frequent reports of the chronic nature of skin ulcers of varying etiology (burns, bedsores, wound diastasis, etc.); these heal with considerable difficulty probably due to problems related to the excessive use of disinfectants which, in spite of having a good bacterial action, interfere with re-epithelialisation processes. The aim of this study was to assess the value of simple wound cleansing instead of disinfection in those cases where there are no manifest signs of bacterial contamination. A widely sold solution, Katoderm (Devergè, Turin), was used in this study. The study was performed in two stages; the first in laboratory animals and the second in patients with small persistent lesions. The results of the study carried out in rats showed a significant prolongation of healing time in the group treated with polyvinylpyrrolidone-iodine compared to those in which lesions were only cleansed with Katoderm. The results of the clinical study also highlighted the faster speed of healing in patients treated with cleansing alone.

Topics: Administration, Topical; Animals; Burns; Detergents; Humans; Povidone-Iodine; Pressure Ulcer; Rats; Skin Ulcer; Wound Healing

Topics: Adult; Carbohydrates; Diabetes Complications; Foot Diseases; Humans; Male; Middle Aged; Povidone; Povidone-Iodine; Skin Ulcer; Wound Healing

Topics: Aged; Female; Foot Diseases; Humans; Male; Middle Aged; Povidone; Povidone-Iodine; Skin Ulcer

Topics: Administration, Topical; Anti-Bacterial Agents; Burns; Candidiasis; Gentamicins; Humans; Mafenide; Pain; Povidone-Iodine; Pruritus; Silver Sulfadiazine; Skin Ulcer; Vitamins; Wound Infection

Topics: Aged; Casts, Surgical; Female; Foot Diseases; Humans; Male; Middle Aged; Perfusion; Povidone-Iodine; Skin Ulcer

The efficacy of topical applications of povidone-iodine (Betadine solution and ointment) for the control of infection associated with decubitus and stasis ulcers was evaluated in 18 male outpatients (age range, 33--68 years). Dressings were changed twice daily over a period of 42 days. Statistically significant improvement was noted in the following signs and symptoms: edema, pain, erythema, ulcer size, and ulcer depth. All patients experienced some degree of symptomatic relief and clinical improvement within two weeks after starting therapy. At the end of the study, 67 percent of the ulcers were clinically cured and 33 percent showed improvement. Acceptance by the patients was excellent, with no reported side effects or sensitization reactions. Povidone-iodine used in a daily regimen of ulcer care can reduce the level of infection and promote healing.

Topics: Administration, Topical; Adult; Aged; Drug Evaluation; Humans; Male; Middle Aged; Povidone; Povidone-Iodine; Pressure Ulcer; Skin Ulcer; Wound Healing

Topics: Anti-Infective Agents, Local; Burns; Humans; Povidone; Povidone-Iodine; Skin Ulcer; Surgical Wound Infection; Wounds and Injuries

Topics: Drug Therapy; Humans; Iodine; Leg Ulcer; Ointments; Povidone; Povidone-Iodine; Skin Ulcer

Topics: Aerosols; Anti-Infective Agents; Anti-Infective Agents, Local; Biomedical Research; Burns; Hexachlorophene; Humans; Infections; Iodine; Povidone; Povidone-Iodine; Skin Ulcer; Solutions; Surgical Procedures, Operative; Surgical Wound Infection