povidone-iodine and Skin-Diseases
povidone-iodine has been researched along with Skin-Diseases* in 17 studies
Reviews
3 review(s) available for povidone-iodine and Skin-Diseases
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The factors involved in deep brain stimulation infection: a large case series.
Deep brain stimulation (DBS) is a proven treatment for various movement disorders resistant to medical management. Complications such as postsurgical infection can negate benefits and increase patient morbidity. We sought to better define risk factors for infection.. We performed a review of DBS cases at our institution from January 1996 to June 2011. Information on multiple metrics including surgical complications, procedural complications and infection were entered into a secure online database.. A total of 447 patients received DBS surgery. Twenty-six (5.82%) developed infection sometime after DBS surgery with 9 (2.01%) developing infection within 30 days after the final staged surgery. Operating surgeon (p = 0.012), scalp erosion (p = 0.0001), surgical incision opening time (0.0001) and number of individuals in the operating room (0.0027) were significant in the cumulative infection group.. The 30-day infection rate was comparably low to other published studies. Several factors were noted to be significant in the cumulative infection group, but none in the 30-day infection group. Further understanding of infection risk factors is important to optimize patient selection and standardize infection-preventative techniques. Topics: Aged; Anti-Infective Agents, Local; Antibiotic Prophylaxis; Chlorhexidine; Comorbidity; Deep Brain Stimulation; Electrodes, Implanted; Female; Humans; Incidence; Infection Control; Male; Middle Aged; Operative Time; Postoperative Period; Povidone-Iodine; Retrospective Studies; Risk Factors; Skin Diseases; Surgical Wound Infection; Wound Closure Techniques | 2014 |
Neonatal dermatology.
Recent advances in neonatology and dermatology have provided us with a better understanding of neonatal and premature infant skin. The problems associated with immature skin become evident immediately after birth and require constant attention throughout the neonatal period. As advances in neonatal care push the gestational age of viability lower, skin maturation and function become increasingly important clinical problems. Premature skin immaturity contributes to elevated water loss, problems with electrolytes and thermoregulation, increased risk of local or systemic infection, increased uptake of potentially toxic agents, and vulnerability to trauma. This review discusses the unique nature of dermal structure and function in very low birth weight infants, evidence of mechanical fragility, toxicity of various topical agents, and the use of emollients. The opinions expressed are those of the authors and do not necessarily represent the views of the Navy or Department of Defense. Topics: Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Infant, Very Low Birth Weight; Ointments; Petrolatum; Povidone-Iodine; Risk Factors; Skin; Skin Diseases; Thyroxine | 1999 |
[Antiseptics in skin diseases].
Topics: Anti-Infective Agents, Local; Antisepsis; Benzalkonium Compounds; Chlorhexidine; Humans; Povidone-Iodine; Skin; Skin Diseases; Skin Diseases, Bacterial | 1996 |
Trials
2 trial(s) available for povidone-iodine and Skin-Diseases
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2% chlorhexidine-70% isopropyl alcohol versus 10% povidone-iodine for insertion site cleaning before central line insertion in preterm infants: a randomised trial.
To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants.. Randomised controlled trial.. Two neonatal intensive care units (NICUs).. Infants <31 weeks' gestation who had a CVC inserted.. Insertion site was cleaned with CHX-IA or PI. Caregivers were not masked to group assignment.. Primary outcome was CR-BSI determined by one microbiologist who was masked to group assignment. Secondary outcomes included skin reactions to study solution and thyroid dysfunction.. We enrolled 304 infants (CHX-IA 148 vs PI 156) in whom 815 CVCs (CHX-IA 384 vs PI 431) were inserted and remained in situ for 3078 (CHX-IA 1465 vs PI 1613) days. We found no differences between the groups in the proportion of infants with CR-BSI (CHX-IA 7% vs PI 5%, p=0.631), the proportion of CVCs complicated by CR-BSI or the rate of CR-BSI per 1000 catheter days. Skin reaction rates were low (<1% CVC insertion episodes) and not different between the groups. More infants in the PI group had raised thyroid-stimulating hormone levels and were treated with thyroxine (CHX-IA 0% vs PI 5%, p=0.003).. We did not find a difference in the rate of CR-BSI between preterm infants treated with CHX-IA and PI, and more infants treated with PI had thyroid dysfunction. However, our study was not adequately powered to detect a difference in our primary outcome and a larger trial is required to confirm our findings.. This study was registered with the EU clinical trials register before the first patient was enrolled (Eudract 2011-002962-19). (https://www.clinicaltrialsregister.eu). Topics: 2-Propanol; Anti-Infective Agents, Local; Catheter-Related Infections; Catheterization, Central Venous; Chlorhexidine; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Povidone-Iodine; Skin Diseases | 2018 |
The use of povidone-iodine aerosol in patients immobilized in plaster of paris.
Topics: Aerosols; Casts, Surgical; Humans; Povidone; Povidone-Iodine; Silicones; Skin Diseases; Tibial Fractures | 1973 |
Other Studies
12 other study(ies) available for povidone-iodine and Skin-Diseases
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Evaluation of wound-healing formulation against sulphur mustard-induced skin injury in mice.
Sulphur mustard (SM) is a bifunctional alkylating agent that causes cutaneous blisters in human and animals. Remedies to SM-induced dermatotoxicity are still in experimental stage. Due to inevitable requirement of a wound-healing formulation against SM-induced skin lesions, efficacy of formulations including povidone iodine, Aloe vera gel, betaine or framycetin sulphate was evaluated in present study. SM was applied percutaneously (5 mg/kg) once on back region of Swiss albino mice; and after 24 hours, DRDE/WH-02 (Defence Research and Development Establishment/ Wound Healant- 02, containing polyvinylpyrrolidone [PVP], A. vera gel and betaine), Ovadine, Soframycin or A. vera gel were applied topically, daily for 3 or 7 days in different groups. Skin sections were subjected to histopathology, histomorphologic grading, tissue leukocytosis, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay and immunohistochemistry of inflammatory-reparative biomarkers. DRDE/WH-02 treated mice received highest score on the basis of histomorphologic scale and lowest number of TUNEL-positive cells compared to other groups. DRDE/WH-02 showed better wound healing as evidenced by widespread re-epithelialization, homogenous fibroplasias well supported by the expression of transforming growth factor-α, endothelial nitric oxide synthase (eNOS) and fibroblast growth factor. Upregulation of interleukin 6 in DRDE/WH-02-treated mice skin resulted in increased tissue leukocytosis and an early removal of tissue debris that initiated reparative process at faster rate compared to other groups. In conclusion, DRDE/WH-02 provided better healing effect and can be recommended as an effective wound healant against SM-induced skin injury. Topics: Aloe; Animals; Betaine; Female; Framycetin; Gels; In Situ Nick-End Labeling; Mice; Mustard Gas; Nitric Oxide Synthase Type III; Plant Extracts; Plant Leaves; Povidone-Iodine; Skin Diseases; Transforming Growth Factor alpha; Wound Healing | 2012 |
Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions.
Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and non-steroidal anti-inflammatory agents. In the mouse, N66 reduced severity of ear edema by 43, 47, 44, and 36%; ear epidermal ulceration by 74, 58, 45, and 58%; and epidermal necrosis by 54, 34, 26, and 31% at the respective time points. A similar effect was observed with encrustation. The healing marker, grade of acanthotic area, showed dramatic increases of 39.6-, 25.3-, 20.9-, and 22-fold. Severity of the dermal parameters, acute inflammation and dermal necrosis, was reduced by 63, 34, 34, and 38% and 80, 54, 54, and 59%, respectively. In guinea pig skin, topical treatment with N66 45 min post-exposure reduced the SM-induced ulceration area by 75%. The histological parameters subepidermal microblister formation, epidermal ulceration, epidermal necrosis, and encrustation were reduced by 63, 61, 41, and 41%, respectively. The healing marker, grade of acanthotic area, was elevated by 73%. N66 induced a statistically significant reduction in two dermal markers for tissue damage: acute inflammation (33%) and dermal necrosis (48%). Reduced skin damage was also observed in areas adjacent the treated sites. The pharmacologically active components of N66 showed additive effect. These findings suggest that the povidone-iodine preparation combined with anti-inflammatory agents functions as a potent antidote against skin lesions induced by SM at relatively long intervals between exposure and treatment. Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Chemical Warfare Agents; Clobetasol; Disease Models, Animal; Drug Combinations; Ear Diseases; Edema; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Mustard Gas; Piroxicam; Povidone-Iodine; Protective Agents; Skin; Skin Diseases; Skin Irritancy Tests; Time Factors | 2004 |
[Livid discoloration of the hand as complication during plexus anaesthesia].
During axillary brachial plexus block for hand surgery, the axillary artery was accidentally punctured. After skin disinfection of the operation site a livid discoloration of the hand appeared. The initial intention of stopping surgery and performing an angiography for clarification of the suspicion of a vessel lesion was dismissed after recording the pulse at the wrist and all fingertips employing a pulsoximeter. Further investigation showed that the livid discoloration of the hand was a product of the interaction of the octenidin solution used for pre-operative hand disinfection with the polyvidone-iodine solution used for surgical skin disinfection. This case report shows that interactions of topically administered pharmaceuticals have to be taken into consideration. Lack of knowledge might lead to unnecessary and unjustified diagnostic procedures which imply additional costs and dangers for the patient. Topics: Aged; Angiography; Anti-Infective Agents, Local; Axillary Artery; Brachial Plexus; Disinfectants; Hand; Humans; Male; Nerve Block; Povidone-Iodine; Skin; Skin Diseases; Skin Pigmentation | 2004 |
Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity.
Recently we have shown that post-exposure treatment with povidone iodine (PI) protects against nitrogen and sulfur mustard-induced skin lesions. Since proteolytic activity is involved in skin damage caused by chemical irritants, we have studied the effect of iodine on mechlorethamine (HN2)-induced skin collagenolytic activities in the haired guinea pig model. The matrix metalloproteinase-9 (MMP-9) activity increased by 30, 46, 12 and 23% after 3, 24, 48 and 72 h of HN2 exposure, respectively, whereas the MMP-2 was elevated by 8, 65, 8 and 30%, respectively. Topical treatment with PI at 15 and 120 min after HN2 exposure decreased the MMP-9 activity by 67% and 60%, respectively, when skin was analyzed 3 h after exposure. The same trend was observed in the MMP-2 and MMP-1 activities after PI treatment. A stronger effect of PI treatment 15 min following exposure was observed in skin analyzed 24 h after exposure, i.e. a decrease of 83% and 88% in MMP-9 and MMP-2 activities, respectively. Similar findings were observed with an interval of 120 min between HN2 exposure and PI treatment. A much weaker effect was observed on MMP-1 activity. A similar trend of PI-induced reduction in the three types of collagenase activity was found in skin analyzed 48 and 72 h after exposure. Reduced collagenolytic activity may serve as one of the mechanisms by which iodine protects the skin against chemical insult. Topics: Administration, Topical; Animals; Dermatologic Agents; Disease Models, Animal; Guinea Pigs; Irritants; Male; Matrix Metalloproteinases; Mechlorethamine; Povidone-Iodine; Skin; Skin Diseases | 2002 |
Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin.
In a previous study we demonstrated the protective effect of topical iodine as postexposure treatment for sulfur mustard (SM) application. The iodine treatment results in significantly reduced inflammation and necrosis and increased epidermal hyperplasia. The expression and localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in paraffin-embedded skin samples from that study were evaluated in the present investigation. We compared the immunoreactivity of iNOS and COX-2 using five samples from each of the following four test sites: untreated control sites, SM-exposed sites, sites treated with iodine mixture 15 min after SM exposure, and sites treated with iodine 30 min after SM exposure. All animals were killed 2 days after irritant exposure. iNOS immunoreactivity was present only in skin sites exposed to SM without iodine treatment. The ulcerated skin was covered with a relatively thick band of exudate composed of iNOS-immunostained polymorphonuclear cells and macrophages. In untreated skin, COX-2 immunostaining was limited to the thin suprabasal epidermal layer. In SM-exposed skin, induction of COX-2 was noted in inflammatory cells located close to the site of epidermal injury. In skin sites treated with iodine 15 or 30 min after SM exposure, the regenerating hyperplastic epithelium showed moderate cytoplasmic staining localized to the epithelium overlying the basal layer. This pattern of staining was also present in the nearby dermal fibroblasts. Thus, in contrast to the skin samples exposed to SM without iodine treatment, the epidermal layer expressing immunohistochemical positivity for COX-2 was thicker and corresponded to the epidermal hyperplasia noted in samples treated with iodine. It is well documented that prostaglandins (PGs) promote epidermal proliferation, thereby contributing to the repair of injured skin. That the induction of the COX-2 shown in our study may also play a role in the healing process is indicated by the present evidence. The results suggest that nitric oxide radicals (NO*) are involved in mediating the damage induced by the SM and that iodine-related reduction in acute epidermal inflammation is associated with reduced iNOS expression. Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Chemical Warfare Agents; Cyclooxygenase 2; Enzyme Induction; Guinea Pigs; Immunoenzyme Techniques; Isoenzymes; Male; Mustard Gas; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Povidone-Iodine; Prostaglandin-Endoperoxide Synthases; Skin Diseases | 2001 |
Topical iodine preparation as therapy against sulfur mustard-induced skin lesions.
Sulfur mustard (SM) is a powerful vesicant employed as an agent of chemical warfare. This study demonstrates the therapeutic effect of a novel topical iodine preparation as a postexposure treatment against SM-induced lesions in the fur-covered guinea-pig skin model. Iodine treatment 15 min after SM exposure resulted in statistically significant reductions of 48, 50, and 55% in dermal acute inflammation, hemorrhage, and necrosis, respectively, whereas, the epidermal healing markers, hyperkerathosis and acanthosis, were significantly elevated by 72 and 67%, respectively, 2 days after treatment. At the interval of 30 min between SM exposure and iodine treatment, there was a significant degree of healing or recovery, albeit to a lesser extent than that observed in the shorter interval. Although the epidermal healing markers were not elevated, the parameters indicative of active tissue damage, such as subepidermal microblisters, epidermal ulceration, dermal acute inflammation, hemorrhage, and necrosis, were significantly reduced by 35, 67, 43, 39, and 45%, respectively. At the 45-min interval between exposure and treatment, there was also a certain degree of healing or recovery expressed as significant reductions in dermal subacute inflammation, subepidermal microblister formation, and epidermal ulceration, whereas, acanthosis was statistically elevated, indicating an increased healing potential. At the 60-min interval, iodine was less efficacious; nevertheless, a significant reduction in the incidence of subepidermal microblisters and an expansion of the acanthotic area were observed. Gross ulceration was significantly decreased at intervals of 15 and 30 min between exposure and treatment. The local anesthetic, lidocaine, did not alter the therapeutic effect of iodine. SM was not affected chemically by iodine as measured by gas chromatography-mass spectrometry (GC-MS) analysis. These findings suggest that the iodine preparation functions as an antidote against skin lesions induced by SM. Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Dermatologic Agents; Disease Models, Animal; Drug Interactions; Guinea Pigs; Irritants; Lidocaine; Male; Mustard Gas; Povidone-Iodine; Skin; Skin Diseases; Time Factors | 2000 |
Early topical treatment with povidone-iodine ointment reduces, and sometimes prevents, skin damage following heat stimulus.
Topics: Anti-Infective Agents, Local; Burns; Hot Temperature; Humans; Ointments; Povidone-Iodine; Skin Diseases; Treatment Outcome | 1998 |
Protective effect of povidone-iodine ointment against skin lesions induced by sulphur and nitrogen mustards and by non-mustard vesicants.
Mustard gas (sulphur mustard, SM) is a powerful vesicant employed as a chemical weapon. The present study demonstrates the effect of povidone iodine (PI) ointment against skin toxicity caused by SM. Gross and histopathological examinations showed that application of PI up to 20 min following exposure to the vesicant resulted in marked skin protection. The shorter the interval between exposure and treatment the better was the protection achieved. PI was also effective against other mustards such as carboxybutyl chloroethyl sulphide (CBCS) and mechlorethamine. The fact that PI protected the skin against agents which cannot be oxidized such as iodoacetic acid, divinylsulphone and cantharidine showed that the antidotal effect of PI was unrelated to oxidation of the nitrogen and sulphur atoms of the mustards. PI ointment is proposed as an efficient protective agent against skin toxicity caused by mustards and other alkylators. Topics: Animals; Anti-Infective Agents, Local; Chemical Warfare Agents; Guinea Pigs; Irritants; Magnetic Resonance Spectroscopy; Male; Mechlorethamine; Mustard Gas; Ointments; Povidone-Iodine; Skin; Skin Diseases | 1997 |
Iododerma complicating cardiovascular surgery.
A patient had cardiovascular surgery and received pericardial povidone-iodine irrigation along with extensive topical povidone-iodine. A postoperative febrile response occurred and persisted despite antibiotic therapy. Within 24 hours of the administration of oral potassium iodide, a pustular iododerma occurred. Discontinuation of oral and topical iodine resulted in defervescence of fever and resolution of the cutaneous eruption. Topics: Coronary Artery Bypass; Humans; Male; Middle Aged; Postoperative Complications; Povidone; Povidone-Iodine; Skin Diseases | 1980 |
The protection of the skin of fracture patients immobilized in plaster of Paris.
Topics: Aerosols; Calcium Sulfate; Female; Fractures, Bone; Humans; Immobilization; Male; Odorants; Pharmaceutic Aids; Povidone; Povidone-Iodine; Pruritus; Silicones; Skin Diseases | 1974 |
The effect of povidone-iodine in controlling skin flora beneath occlusive dressings.
Topics: Foot Dermatoses; Foot Diseases; Humans; Infection Control; Occlusive Dressings; Povidone; Povidone-Iodine; Skin; Skin Diseases | 1970 |
THE EFFECTS OF POVIDONE-IODINE IN THE TREATMENT OF BURNS AND TRAUMATIC LOSSES OF SKIN.
Topics: Anti-Infective Agents, Local; Burns; Drug Therapy; Halogens; Humans; Hydrocarbons, Halogenated; Povidone-Iodine; Skin Diseases; Wounds and Injuries | 1965 |