povidone-iodine and Seizures

We present a case study of a severe episode of iodine toxicity following povidone-iodine wash with clinical manifestations of cardiovascular collapse, metabolic acidosis, renal failure and seizures. Povidone-iodine has been used as a medical antiseptic and disinfectant since 1952 Iodine toxicity secondary to povidone-iodine use is rare. Iodine toxicity is difficult to diagnose and the diagnosis is made by a high index of suspicion. Toxicity due to iodine correlates with serum and urine iodine levels. Treatment of iodine toxicity is supportive. A review of literature relating to the components of povidone-iodine, iodine metabolism, its manifestations and management of iodine toxicity secondary to povidone-iodine is also presented. An Ovid-Medline search from 1950 to 2009 revealed 1236 articles on the clinical manifestations of povidone-iodine usage but no article on iodine toxicity relating to povidone-iodine based on the following search criteria: povidone-iodine and/or iodine toxicity secondary to povidone-iodine (limited to English language, review articles, full text and human patients).

Topics: Acidosis; Aged; Anti-Infective Agents, Local; Anticonvulsants; Diuretics; Fluid Therapy; Follow-Up Studies; Furosemide; Heart Arrest; Hemodiafiltration; Humans; Iodine; Male; Povidone-Iodine; Renal Insufficiency; Seizures; Therapeutic Irrigation

Topics: Deafness; Humans; Mediastinal Diseases; Neomycin; Polymyxins; Povidone-Iodine; Seizures; Therapeutic Irrigation

Topics: Animals; Contrast Media; Humans; Iodine; Mediastinum; Povidone-Iodine; Seizures; Therapeutic Irrigation

Topics: Humans; Male; Mediastinum; Middle Aged; Povidone-Iodine; Seizures; Therapeutic Irrigation