povidone-iodine and Pain--Postoperative

To compare the clinical efficacy of different povidone iodine concentrations for the management of postoperative pain and swelling following mandibular third molar surgery.. The randomised, prospective, double-blind and controlled study was conducted from October 2016 to January 2018 at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Biruni University, Istanbul, Turkey, and comprised individuals aged 18-30 years who underwent surgical removal of pathology-free completely unerrupted mandibular lower third molars. The participants were randomly assigned to four groups: Group I had saline-only controls, Group II was given 0.5% concentration of povidone iodine, Group III had 1% concentration of povidone iodine, and Group IV had 3% concentration of povidone iodine. Facial swelling and trismus were assessed on the 2nd and 7th postoperative days. Data was analysed using SPSS 22.. Of the 80 patients, 34(42.5%) were males and 46 (57.5%) were females with an overall mean age of 24.6±3.68 years. Each group had 20 (25%) subjects. All three concentrations of povidone iodine provided significant reduction in postoperative trismus compared to the controls. Trismus was less in Group III and Group IV compared to Group II up to 7 days after surgery.. Irrigation with 3% povidone iodine concentration was found to be more effective in reducing the level of facial swelling after impacted third molar surgery. (Clinical Trials.gov Identifier: NCT03894722).

Topics: Adolescent; Adult; Edema; Female; Humans; Male; Mandible; Molar, Third; Pain, Postoperative; Povidone-Iodine; Prospective Studies; Tooth Extraction; Tooth, Impacted; Trismus; Turkey; Young Adult

The present study was conducted to assess the effect of irrigation with three different irrigants, namely normal saline, chlorhexidine, and povidone iodine on pain, alveolar osteitis, swelling, trismus, infection, and food impaction during surgical removal of impacted mandibular third molar.. Forty-eight patients, including 26 males and 22 females, fulfilling criteria for inclusion in this study were divided into three groups: group I where irrigant used was normal saline, group II as chlorhexidine, and group III as povidone iodine group.. The pain was significantly more in groups I and III in 24 hours and 7th day as well. Alveolar osteitis was noted in groups III and I, nil in group II. The facial swelling measured in millimeters on 24 hours and on 7th day was significantly higher in 24 hours in groups I and III than in group II. Trismus was significantly more in group I and group III than in group II (with p < 0.01) on 7th day.. It is concluded that chlorhexidine is effective in reducing pain, alveolar osteitis, swelling, and trismus when used as an irrigant following surgical removal of impacted third molar.. Chlorhexidine as irrigating solution helps in reducing the postoperative consequences after third molar surgery. Further studies are required using large sample size.

Topics: Adult; Chlorhexidine; Cross-Sectional Studies; Dry Socket; Edema; Female; Humans; Intraoperative Care; Male; Molar, Third; Pain, Postoperative; Postoperative Complications; Povidone-Iodine; Saline Solution; Solutions; Therapeutic Irrigation; Tooth Extraction; Tooth, Impacted; Treatment Outcome; Trismus; Young Adult

To assess the effect of povidone iodine versus benzalkonium chloride, which were applied preoperatively for vaginal disinfection in caesarean sections, on postoperative factors.. One hundred and twenty patients underwent elective caesarean section were divided into three groups using the simple randomisation method: Group 1 (povidone iodine, n: 41); Group 2 (benzalkonium chloride, n: 39); Group 3 (control group, n: 40). Demographic data, duration of operation, amount of bleeding, postoperative pain, time to first flatulence and defaecation, haematological parameters on postoperative day 1 were compared between three groups. Pain evaluation was performed at 6th and 24th postoperative hour using Visual Analogue Scale.. No statistically significant differences were detected between the groups in demographic characteristics. There were no significant differences between the groups with respect to the duration of operation and hospital stay. The patients in the group who underwent povidone iodine vaginal cleansing had statistically significantly less postoperative pain as compared to control group. No difference was observed between the groups in haematological parameters other than C-reactive protein (CRP); however, CRP levels at 24th post-operative hour were significantly lower in Group 1 compared to the other groups.. The preoperative vaginal cleansing with povidone iodine could reduce the postoperative pain, analgesic need and infection parameter.

Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Benzalkonium Compounds; Cesarean Section; Disinfection; Elective Surgical Procedures; Female; Humans; Pain Measurement; Pain, Postoperative; Postoperative Period; Povidone-Iodine; Pregnancy; Prospective Studies; Surgical Wound Infection; Vagina; Young Adult

Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently.. A randomized controlled clinical trial was performed in 30 patients undergoing mandibular third molar removal in a split-mouth design. In the study group, a povidone iodine solution with a concentration of 0.5 mg/mL was used as the coolant and irrigant solution, whereas normal saline was used in the control group. Swelling (orotragus and mentotragus distances), trismus (maximum interincisal opening), and pain (visual analog scale score) were evaluated on postoperative days 2 and 7.. In the study group, a significant decrease in swelling and trismus was observed at the 2 postoperative visits (P = .00) compared with the control group. The decrease of pain in the study group was not statistically significant at either postoperative visit (P > .05). More patients (63%) were subjectively satisfied with the side treated with povidone iodine.. Povidone iodine irrigation is an inexpensive and safe method to lessen the postoperative sequelae of third molar surgery.

Topics: Adolescent; Adult; Anti-Infective Agents, Local; Edema; Female; Follow-Up Studies; Humans; Male; Mandible; Molar, Third; Pain, Postoperative; Patient Satisfaction; Pilot Projects; Postoperative Complications; Povidone-Iodine; Prospective Studies; Sodium Chloride; Therapeutic Irrigation; Tooth Extraction; Tooth, Impacted; Trismus; Visual Analog Scale; Young Adult

To evaluate the use of 5% povidone-iodine drop with subconjunctival injection of dexamethasone and gentamicin combination at the completion of phacoemulsification cataract surgery. This prospective randomized study was conducted at the department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July, 2005 to June 2006. Senile & pre-senile cataract patients undergoing phacoemulsification cataract surgery were included in the study. Thirty patients were randomly included in Group A, receiving sub-conjunctival injection of dexamethasone and gentamicin combination and 30 patients in Group- B, receiving 5% povidone-iodine drop at the end of phacoemulsification surgery. Protocol for pre-operative medications, phacoemulsification technique and post-operative medications were similar in both groups. All patients were followed for 6 months post-operatively. Outcome measures were i) patients experience of pain and discomfort post-operatively ii) grade of inflammation post-operatively and iii) visual outcome. Difference of data between two groups was analyzed by unpaired 't' test and chi-square test. In Group A, mean age were 56.86+/-10.25 (SD) years and in Group B, mean age was 57.70+/-10.25 (SD) years. In Group A, 18(60%) patients were male and 12(40%) were female. In Group B, 16(53.33%) were male and 14(46.67%) were female. Pain and discomfort perceived by patients were measured by VAS at the end of operation, on 1st POD and after 7 days post-operatively. Mean VAS score was 5.7 in Group A and 2.7 in Group B at the end of surgery, 2.5 in Group A and 2.2 in Group B on 1st POD and 0.7 in Group A and 0.6 in Group B on 7th POD. Post-operative inflammation was assessed by slit lamp considering conjunctival congestion, chemosis, corneal striation, corneal oedema, cells and flare in anterior chamber. No significant difference was observed between two groups. Mean visual acuity was 0.16+/-0.12 in Group A and 0.15+/-0.13 in Group B. Anti-inflammatory, anti-infective effects and visual outcome are similar in both groups. But sub-conjunctival injection resulted more pain and hence less acceptable to patients.

Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Chi-Square Distribution; Dexamethasone; Female; Gentamicins; Glucocorticoids; Humans; Injections; Male; Middle Aged; Ophthalmic Solutions; Pain, Postoperative; Phacoemulsification; Postoperative Complications; Povidone-Iodine; Prospective Studies; Treatment Outcome

To investigate the effects of lidocaine gel and parenteral antibiotics and povidine lavage in the treatment of pain occurring during prostate biopsy in terms of infective complications.. Eighty patients with indications for prostate biopsy were randomized into two groups. One group underwent lavage with povidine iodine solution and lidocaine gel, and the other received cephtriaxon and lavage. Pain experienced by the patients was measured by visual analog scale (VAS). Blood samples were taken 15 and 60 min after the procedure, and urine culture antibiograms were taken 60 min after the procedure.. The average pain score was 3.70 in Group 1 and 4.25 in Group 2; the difference between the groups was not statistically significant (P > 0.05). Likewise, no statistically significant difference between groups was found by the chi square test in either urine or blood cultures (P > 0.05).. Lavage with betadine prior to transrectal prostate biopsy is adequate in the prevention of infective complications; however, because lidocaine gel is not effective against pain, alternative methods for pain management need to be developed.

Topics: Aged; Aged, 80 and over; Anesthetics, Local; Anti-Infective Agents; Antibiotic Prophylaxis; Biopsy, Needle; Cefuroxime; Gels; Humans; Infusions, Parenteral; Lidocaine; Male; Middle Aged; Pain, Postoperative; Phosphates; Povidone-Iodine; Prospective Studies; Prostate; Rectum; Surgical Wound Infection; Therapeutic Irrigation

Chlorhexidine is better than povidone iodine for skin preparation before intravascular device insertion or blood culture collection, but it is not known whether chlorhexidine is superior in reducing colonization of continuous epidural catheters.. Children requiring an epidural catheter for postoperative analgesia longer than 24 h were randomly assigned to receive skin preparation with an alcoholic solution of 0.5% chlorhexidine or an aqueous solution of 10% povidone iodine before catheter insertion. Using surgical aseptic techniques, catheters were inserted into either the lumbar or the thoracic epidural space based on the preferences of the anesthesia team, on clinical indication, or both. Immediately before epidural catheter removal, their insertion site and hub were qualitatively cultures. After their removal, the catheter tips were quantitatively cultured. Catheters were classified as colonized when their tips yielded 1,000 or more colony-forming units/ml in cultures.. Of 100 randomly assigned patients, 96 were evaluable. The clinical characteristics of the patients and the risk factors for infection were similar in the two groups. Catheters were kept in place for a median (range) duration of 50 (range, 21-100) h. Catheters inserted after skin preparation with chlorhexidine were one sixth as likely and less quickly to be colonized as catheters inserted after skin preparation with povidone iodine (1 of 52 catheters [0.9 per 100 catheter days] vs. 5 of 44 catheters [5.6 per 100 catheter days]; relative risk, 0.2 [95% confidence interval, 0.1-1.0]; P = 0.02). Coagulase-negative staphylococci were the only colonizing microorganisms recovered, and the skin surrounding the catheter insertion site was the origin of all the colonizing microorganisms.. Compared with aqueous povidone iodine, the use of alcoholic chlorhexidine for cutaneous antisepsis before epidural catheter insertion reduces the risk of catheter colonization in children.

Topics: Adolescent; Analgesia, Epidural; Anti-Infective Agents, Local; Bacteria; Catheterization; Child; Child, Preschool; Chlorhexidine; Female; Humans; Infant; Male; Pain, Postoperative; Povidone-Iodine; Prospective Studies; Skin

Pleurodesis is one of the best methods of controlling malignant pleural effusions (MPE), a distressing complication of metastatic disease. In recent studies of a wide range of pleural diseases, iodopovidone was used as a sclerosing agent for pleurodesis and demonstrated good results with low morbidity. The aim of this study was to evaluate the efficacy and safety of iodopovidone pleurodesis in MPE.. A retrospective analysis was performed on patients with MPE who underwent pleurodesis at our institution between 2005 and 2008. All patients underwent instillation of 20 mL of 10% iodopovidone, 80 mL of normal saline and 2 mg/kg of lidocaine through a chest tube, which was clamped for 2 h. The tube was removed when the daily output of fluid was <200 mL. Data on the requirement for additional pleural procedures, adverse events and survival were collected.. Sixty-one pleurodesis procedures were performed in 54 patients. No procedure-related mortality was observed. Adverse events occurred after 11 (18%) pleurodesis procedures. The most frequent complication was mild thoracic pain that occurred immediately after 10 (16.4%) procedures, and one patient developed pleural empyema that was treated with drainage and antibiotics. A success rate of 98.4% was observed. Except for the patient who developed pleural empyema, none of the other patients had recurrences of pleural fluid or required additional pleural procedures during the follow-up period (mean of 5.6 months).. Iodopovidone pleurodesis was successful and was associated with only a few minor complications. It appears to be a good option for the management of recurrent MPE.

Topics: Adult; Aged; Anti-Bacterial Agents; Drainage; Empyema, Pleural; Female; Humans; Lidocaine; Male; Middle Aged; Pain, Postoperative; Pleural Effusion, Malignant; Pleurodesis; Povidone-Iodine; Retrospective Studies; Treatment Outcome