povidone-iodine and Otitis-Externa

To determine the efficacy of Burow's solution as an otologic preparation for the treatment of chronic ear infection.. Two studies were included: 1) a prospective clinical study and 2) a laboratory study on antibacterial and antifungal effects.. A private otology practice and a laboratory study.. Fifty-eight patients with refractory otorrhea.. Diagnosis by otoscopy, audiometry, and bacteriology.. Burow's solution was mixed in solutions with four organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Candida albicans, and Aspergillus. Soon after Burow's solution was mixed in the solutions with organisms, and 5, 10, and 20 minutes thereafter, the mixtures were cultured on agars. The numbers of the bacterial or fungal colonies were counted to evaluate the effect of Burow's solution.. Changes in the clinical findings of the ears, the symptom of otorrhea, and side effects were assessed.. Thirty-five (70%) of the 50 ears assessed were "cured" and 10 (20%) ears assessed were "improved." No significant side effect was observed. Regarding the laboratory study, the four organisms disappeared within 20 minutes after Burow's solution was mixed.. Burow's solution was considered to be an effective otologic preparation.

Topics: Acetates; Anti-Infective Agents, Local; Aspergillus; Candida albicans; Chronic Disease; Female; Humans; Male; Microbial Sensitivity Tests; Otitis Externa; Otitis Media; Povidone-Iodine; Prospective Studies; Staphylococcus aureus; Streptococcus pneumoniae

Repeated applications of low-concentration povidone iodine (PI) combined with dexamethasone (Dex) through a tympanic membrane ventilation tube will not cause ototoxic changes in the rat.. Otitis externa (OE) and acute otitis media (AOM) are 2 of the most common otologic disorders requiring outpatient antibiotic treatment. The development of topical treatments that are easy to administer would help to limit systemic exposure to antibiotics in these patients. Topical formulations containing Dex and low-dose PI were designed to provide both antimicrobial and anti-inflammatory effects for the treatment of OE and AOM. Treatment with PI alone has shown mixed results in studies designed to determine PI. Low concentrations of PI combined with Dex should yield less ototoxicity while maintaining effectiveness.. We performed tympanostomies on rats, inserting a ventilation tube to administer 1% or 2% PI, plus 0.1% Dex over a period of 7 days. Hearing was accessed via auditory brainstem response (ABR) testing over the duration of the study and histologic analysis was performed 15 days after the initial application to determine the effect of administration of PI/Dex on middle and inner ear structures.. The preparations used in the present investigation were formulated to allow repeated applications to both the external and middle ear, without risk to hearing or equilibrium. Neither of the PI/Dex formulations tested caused pathologic changes in the ear that significantly affected equilibrium, hearing function or morphology.

Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dexamethasone; Drug Delivery Systems; Male; Otitis Externa; Otitis Media; Povidone-Iodine; Rats; Rats, Sprague-Dawley; Tympanic Membrane