povidone-iodine and Nervous-System-Diseases

Topics: Anti-Infective Agents, Local; Bandages; Electroencephalography; Humans; Hydrocarbons, Iodinated; Hyperthyroidism; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Diseases; Povidone-Iodine; Shock, Septic; Thyrotropin; Thyroxine

In experiment 1, we evaluated our method of catheter care at subclavian vein insertion sites for the control of catheter-related infections in seriously ill neurosurgical patients who needed prolonged catheter placement, compared with an older method. In our method, the insertion site was prepared with 10% povidone-iodine solution, followed by application of 10% povidone-iodine ointment, and covered with sterile gauze and a transparent polyurethane dressing. The older method was based on 1996 guidelines for the prevention of intravascular device-related infections. Catheter colonization and mortality were both found to be significantly reduced with our method (p = 0.0214, p = 0.0379, respectively). In experiment 2, we evaluated whether a regimen of catheter care with 10% povidone-iodine ointment was more effective than that without povidone-iodine ointment for the prevention of infections. This suggested effectiveness of 10% povidone-iodine ointment for reduction of infection. Our method of catheter care was useful even in seriously ill neurosurgical patients.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Bacterial Infections; Bandages; Catheterization, Central Venous; Catheters, Indwelling; Cross Infection; Equipment Contamination; Humans; Infection Control; Middle Aged; Nervous System Diseases; Neurosurgical Procedures; Ointments; Povidone-Iodine; Skin Care; Solutions; Subclavian Vein