povidone-iodine and Leukocytosis

Povidone-iodine caused peritonitis with neutrophilic leukocytosis and a minimal left shift at the dosage rate of 3.5 ml/kg body weight. A dosage rate of 2 ml/kg only caused slight neutrophilic leukocytosis. There was a significant increase in the levels of creatinine (p = 0.049) and BUN (p = 0.020) in dogs that received the higher dose rate. Two dogs died from povidone-iodine toxicity with a marked increase in ALT, AP, SDH and conjugated bilirubin. It is concluded that povidone-iodine is unsafe for use in the peritoneal cavity of dogs.

Topics: Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Dog Diseases; Dogs; Female; Injections, Intraperitoneal; Leukocytosis; Liver Diseases; Male; Neutrophils; Peritonitis; Povidone; Povidone-Iodine