povidone-iodine and Herpes-Genitalis

Topics: Administration, Topical; Clinical Trials as Topic; Drug Combinations; Female; Gels; Herpes Genitalis; Humans; Male; Povidone; Povidone-Iodine

The clinical value of aciclovir, oral or topical, in the episodic treatment of recurrent herpes virus infection is limited. Betadine (povidone-iodine) could provide a cheap, effective alternative for managing symptomatic recurrences. We describe a case where povidone-iodine was used successfully to treat a recurrence of genital herpes simplex and review the literature supporting povidone-iodine in the treatment of genital tract infections.

Topics: Adult; Antiviral Agents; Female; Herpes Genitalis; Herpes Simplex; Humans; Povidone-Iodine

Microbicide candidates were selected that have demonstrated activity against sperm or sexually transmitted disease pathogens in vitro, and the efficacy of these agents for preventing vaginal transmission of genital herpes infection was evaluated in the progestin-treated mouse. Each agent was delivered to the vaginas of mice approximately 20 sec prior to delivering a highly infectious herpes simplex virus-2 inoculum. The following agents provided significant protection: anti-HSV monoclonal antibodies III-174 and HSV8, modified bovine beta-lactoglobulin (beta-69), carrageenan, concanavalin A, chlorhexidine, dextran sulfate (average molecular weight 8,000 and 500,000), fucoidan, neem, nonoxynol-9, polystyrene sulfonate, and povidone-iodine. Two agents, gramicidin and heparan sulfate, though highly effective in vitro, were not protective in vivo at the doses tested.

Topics: Animals; Anti-Infective Agents; Antibodies, Monoclonal; Antiviral Agents; Carrageenan; Chlorhexidine; Concanavalin A; Female; Herpes Genitalis; Herpesvirus 2, Human; Lactoglobulins; Mice; Mice, Inbred C57BL; Nonoxynol; Polysaccharides; Polystyrenes; Povidone-Iodine; Vagina

Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Antiviral Agents; Cytarabine; Dimethyl Sulfoxide; Female; Herpes Genitalis; Humans; Idoxuridine; Male; Povidone-Iodine; Vidarabine