povidone-iodine and Hemorrhage

Due to its excellent microbicidal activity, povidone-iodine (PVP-I) is used for local anti-infective treatment, especially for wound antisepsis of the skin. Previous studies have shown that liposomal PVP-I formulations are less cytotoxic and that a special liposomal PVP-I hydrogel provides wound healing efficacy.. In the present study, the angiotoxic activity of the liposomal and the aqueous PVP-I formulations were comparatively tested at the chorioallantoic membrane (CAM) of chick embryos.. Test preparations were administered onto the CAM of ex ovo cultivated chick embryos. At different time intervals, the local irritation of the blood vessels was examined microscopically and assigned to a score of vascular injury.. Angioirritative reactions of the CAM were manifest as coagulation, vascular congestion and hemorrhages. The liposomal formulations containing 0.1, 0.5 or 1% PVP-I were found to be significantly less angiotoxic than the corresponding aqueous formulations.. The angioirritative potential of PVP-I is significantly reduced by its liposomal encapsulation.

Topics: Animals; Anti-Infective Agents, Local; Chemistry, Pharmaceutical; Chick Embryo; Dose-Response Relationship, Drug; Drug Delivery Systems; Extraembryonic Membranes; Hemorrhage; Liposomes; Models, Animal; Povidone-Iodine; Probability; Sensitivity and Specificity; Water