povidone-iodine and Haemophilus-Infections

In a double-blind randomized study we evaluated the efficacy of povidone-iodine in the treatment of clue cell-positive discharge (CCPD). Vaginal pessaries (200 mg povidone-iodine or placebo) were taken twice daily for five consecutive days. Although the regimen was reasonably well accepted, 'messiness' was reported by 13 of 33 women (39%). Of 44 women enrolled, treatment efficacy was evaluated in 28 women who had both follow-up visits. There was no significant difference in the efficacy of povidone-iodine and placebo pessaries, at either the first or the second follow-up visit (p values 0.46 and 1 respectively). It is concluded that the use of povidone-iodine pessaries, at least in the regimen described, cannot be regarded as an effective therapy for CCPD.

Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gardnerella vaginalis; Haemophilus Infections; Humans; Pessaries; Placebos; Povidone; Povidone-Iodine; Vaginitis

In a study of 100 women with non-specific vaginitis, characterised by a vaginal discharge which was malodorous and pruritic in most cases and caused dyspareunia and dysuria in some, Gardnerella vaginalis was isolated in 46% of patients. When present, G vaginalis was significantly associated with Mycoplasma hominis and Bacteroides species. Isolation of G vaginalis was unrelated to the presenting symptoms. Treatment with povidone-iodine pessaries for two weeks produced no pronounced benefit, either clinically or microbiologically, compared with a placebo. Nevertheless, 68% of all patients followed reported improvement four weeks after the start of treatment. The findings suggest that G vaginalis is one cause of non-specific vaginitis, which is more likely to be seen in women using oral contraceptives and is usually cured spontaneously.

Topics: Adolescent; Adult; Clinical Trials as Topic; Contraceptives, Oral; Double-Blind Method; Female; Gardnerella vaginalis; Haemophilus Infections; Humans; Middle Aged; Povidone-Iodine; Vaginitis

Topics: Anti-Infective Agents, Local; Chest Tubes; Empyema, Pleural; Haemophilus Infections; Haemophilus influenzae; Humans; Male; Middle Aged; Pneumonectomy; Povidone-Iodine; Radiography; Therapeutic Irrigation; Thoracostomy; Treatment Outcome