povidone-iodine and Filariasis

povidone-iodine has been researched along with Filariasis* in 1 studies

Trials

1 trial(s) available for povidone-iodine and Filariasis

ArticleYear
Is povidone iodine an alternative to silver nitrate for renal pelvic instillation sclerotherapy in chyluria?
    BJU international, 2004, Volume: 94, Issue:7

    To compare the efficacy and toxicity of 1% silver nitrate, 0.2% povidone iodine and 50% dextrose in renal pelvic instillation sclerotherapy (RPIS) for chyluria.. In a prospective randomized comparative study from January 1999 to June 2003, 106 patients (61 males and 45 females; mean age 36 years, sd 12, range 14-65) were randomized to receive 1% silver nitrate, 0.2% povidone iodine or 50% dextrose as RPIS. In all, nine doses were given at 8-h intervals, and patients followed at 6 weeks and then at 3-monthly intervals. Patients with 'persistence' or 'recurrence' of chyluria were treated with second course of RPIS using same sclerosant.. The dextrose treatment was discontinued at mid-term because of poor success (one of 21 patients, P < 0.001). Of 85 patients, 44 received silver nitrate and 41 povidone iodine; both groups were well-matched and the mean follow-up was 28.4 and 23.3 months, respectively. 'Immediate clearance' was recorded in 91% and 98%, and recurrence in 21% and 22% of patients after the first course of RPIS, after silver nitrate and povidone, respectively; Kaplan-Meier estimates of 'disease-free duration' in the two groups (23.6 vs 20.1 months) were also similar (P = 0.7906). The cumulative success rate after two courses of RPIS was 82% (silver nitrate) and 83% (povidone; P = 1.0). Five (11%) patients in the silver nitrate and one (2%) in the povidone group had significant flank pain during treatment.. Povidone iodine 0.2% is as effective for RPIS as 1% silver nitrate.

    Topics: Adolescent; Adult; Aged; Animals; Anti-Infective Agents, Local; Chyle; Disease-Free Survival; Female; Filariasis; Humans; Injections; Kidney Pelvis; Male; Middle Aged; Povidone-Iodine; Prospective Studies; Recurrence; Sclerotherapy; Silver Nitrate; Urine; Wuchereria bancrofti

2004