povidone-iodine and Eosinophilia

Secondary hydatidosis is an important problem encountered during the surgical treatment of hydatid cysts. This study describes an experimental model of secondary hydatidosis by cyst inoculation, used to explore whether simultaneous inoculation of protoscolocidal agents could prevent secondary hydatidosis. Fertile cyst fluid was injected into the pleural space of rabbits alone (group 1, n = 8), and in combination with 2% albendazole solution (group 2, n = 8), 20% hypertonic saline (group 3, n = 8) or 10% povidone-iodine (group 4, n = 8). Computed tomography imaging of the thorax, indirect haemagglutination (IHA) titres and eosinophil counts were used to determine cyst development. After 16 months, three control rabbits had pneumothorax, seven had cysts and four had parenchymal nodules. Histopathological investigation of nodules revealed 87.5% cyst formation. Pleural thickening was observed in rabbits from all groups. Cyst formation rates, IHA titres and eosinophilia counts were higher in group 1 than in groups 2-4. This study demonstrated the experimental formation of secondary hydatidosis and found that topical protoscolocidal agents were beneficial in preventing cyst recurrence.

Topics: Albendazole; Animals; Anthelmintics; Anti-Infective Agents, Local; Echinococcosis, Hepatic; Eosinophilia; Male; Pneumothorax; Povidone-Iodine; Rabbits; Saline Solution, Hypertonic; Tomography, X-Ray Computed; Treatment Outcome

Topics: Allergens; Back; Dermatitis, Allergic Contact; Diagnosis, Differential; Eosinophilia; Humans; Leg; Male; Middle Aged; Patch Tests; Povidone-Iodine; Severity of Illness Index

Povidone is an allergic agent present in numerous substances, food and medicines. The authors present the clinical case of a 9-yr-old male child admitted in the emergency room with anaphylaxis, in two occasions separated by a 6-month period. The first episode occurred 5 min after the first oral administration of Fluvermal (flubendazole) and the second occurred 10 min after cutaneous application of Betadine (povidone iodine solution). Previous cutaneous application of this solution and ingestion of mebendazole occurred without apparent adverse reactions. The allergy study revealed eosinophilia, an elevated total IgE level and positive prick-by-prick test for both drugs. A cutaneous prick-by-prick test with povidone (the sole common constituent) was also positive. This is probably the first case described in the literature of anaphylaxis induced by povidone in a child.

Topics: Anaphylaxis; Anti-Infective Agents, Local; Antinematodal Agents; Child; Conjunctivitis, Allergic; Dermatitis, Atopic; Eosinophilia; Humans; Immunoglobulin E; Male; Mebendazole; Pharmaceutic Aids; Povidone; Povidone-Iodine; Skin Tests