povidone-iodine and Dermatitis--Occupational

A quick drying rubbing type disinfectant of non-water non-towel type is an antiseptic method suitable for practical use in intensive care units where emergency situations are common. We determined the antiseptic efficacy and safety of a quick drying rubbing type povidone-iodine alcoholic disinfectant solution (HAD Hand Wash) in comparison with benzalkonium chloride alcoholic lotion. The bacterial reduction rate obtained by hand washing with a single 3 ml application was 93.8% for HAD Hand Wash and 94.1% for benzalkonium chloride alcoholic lotion. Thus, excellent antiseptic efficacy was obtained with both disinfectants. Roughening of hand skin which appeared in association with HAD Hand Wash solution was transient and mild in nature in all of the cases, indicating the high safety of this disinfectant. It is justified to say from these findings that HAD Hand Wash is useful as a hand and finger disinfectant.

Topics: Antisepsis; Bacteria; Benzalkonium Compounds; Dermatitis, Occupational; Ethanol; Hand; Hand Disinfection; Humans; Medical Staff, Hospital; Povidone-Iodine

Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics, in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and the risk of subsequent iodine overdose.. To report on concomitant patch test reactions observed with iodine and IPBC in patients sensitized to iodine-containing antiseptics.. Between 2012 and 2018, seven patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis caused by wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and/or povidone-iodine (PVP-I), which was considered to be relevant for their dermatitis. All patients were coincidentally also patch tested with IPBC.. All patients showed positive patch test reactions to several other allergens, including IPBC. No relevance could be detected for IPBC.. We suspect that, notwithstanding the absence of firm evidence for IPBC being dehalogenated to produce free iodine in animals or in humans, the patch test reactions to IPBC in iodine-allergic subjects were possibly caused by free iodine released from this preservative agent, thus underlining the EU restrictions regarding the use of this preservative in cosmetics.

Topics: Adult; Aged; Anti-Infective Agents, Local; Carbamates; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Humans; Iodine; Male; Middle Aged; Patch Tests; Postoperative Complications; Povidone-Iodine

Topics: Aged; Chronic Disease; Dermatitis, Contact; Dermatitis, Occupational; Female; Hand Dermatoses; Humans; Middle Aged; Povidone-Iodine

Topics: Abattoirs; Adult; Dermatitis, Contact; Dermatitis, Occupational; Humans; Male; Povidone; Povidone-Iodine