povidone-iodine and Dermatitis--Irritant

Povidone-iodine solution is an antiseptic that is used worldwide as surgical paint and is considered to have a low irritant potential. Post-surgical severe irritant dermatitis has been described after the misuse of this antiseptic in the surgical setting.. Between January 2011 and June 2013, 27 consecutive patients with post-surgical contact dermatitis localized outside of the surgical incision area were evaluated. Thirteen patients were also available for patch testing.. All patients developed dermatitis the day after the surgical procedure. Povidone-iodine solution was the only liquid in contact with the skin of our patients. Most typical lesions were distributed in a double lumbar parallel pattern, but they were also found in a random pattern or in areas where a protective pad or an occlusive medical device was glued to the skin. The patch test results with povidone-iodine were negative.. Povidone-iodine-induced post-surgical dermatitis may be a severe complication after prolonged surgical procedures. As stated in the literature and based on the observation that povidone-iodine-induced contact irritant dermatitis occurred in areas of pooling or occlusion, we speculate that povidone-iodine together with occlusion were the causes of the dermatitis epidemic that occurred in our surgical setting. Povidone-iodine dermatitis is a problem that is easily preventable through the implementation of minimal routine changes to adequately dry the solution in contact with the skin.

Topics: Adult; Aged; Anti-Infective Agents, Local; Dermatitis, Irritant; Female; Humans; Male; Middle Aged; Postoperative Complications; Povidone-Iodine

Topics: Anti-Infective Agents, Local; Bandages; Dermatitis, Allergic Contact; Dermatitis, Irritant; Humans; Iodine Compounds; Iodophors; Povidone-Iodine; Wound Infection; Wounds and Injuries

Topics: Dermatitis, Allergic Contact; Dermatitis, Irritant; Humans; Irritants; Patch Tests; Povidone-Iodine

Topics: Adult; Anti-Infective Agents, Local; Antineoplastic Agents; Central Venous Catheters; Cyanoacrylates; Dermatitis, Allergic Contact; Dermatitis, Irritant; Humans; Male; Povidone-Iodine; Testicular Neoplasms; Tissue Adhesives

Topics: Aged, 80 and over; Anti-Infective Agents, Local; Dermatitis, Irritant; Humans; Male; Povidone-Iodine

Topics: Aged; Anti-Infective Agents, Local; Dermatitis, Irritant; Diagnosis, Differential; Female; Humans; Povidone-Iodine; Stevens-Johnson Syndrome

A contact dermatitis due to to povidone-iodine (PI) which seemed to be a strong irritant reaction is described. Nevertheless, patch-test results suggested an allergic reaction that is cell mediated.

Topics: Adult; Anti-Infective Agents, Local; Dermatitis, Allergic Contact; Dermatitis, Irritant; Humans; Male; Patch Tests; Povidone-Iodine

10 cases of contact dermatitis which began during the application of povidone-iodine preparations were examined with patch tests using 2 kinds of povidone-iodine preparations and their ingredients, i.e., povidone-iodine, polyoxyethylene nonylphenyl ether and glycerin, and also the components of povidone-iodine, i.e., iodine and polyvinylpyrrolidone. All 10 cases reacted positively to the povidone-iodine preparations and povidone-iodine, 3 out of the 10 to polyoxyethylene nonylphenyl ether, 1 out of the 9 tested to iodine, while no positive response was found to glycerin or polyvinyl-pyrrolidone. It was difficult to distinguish between allergic responses from irritation, as responses to patches of povidone-iodine and its preparations usually include irritation at high frequencies. Based on comparison of results with a control group, however, those showing + or stronger reactions to 2% povidone-iodine at days 3 to 5 were considered to be allergic. Thus, 4 out of the 10 cases were considered as sensitization to povidone-iodine. Another 3 cases were found to be polyoxyethylene nonylphenyl ether sensitized, and another 1 iodine sensitized, while the patch test reactions of the other 2 were considered to have been elicited by irritation.

Topics: Adult; Aged; Aged, 80 and over; Allergens; Anti-Infective Agents, Local; Dermatitis, Allergic Contact; Dermatitis, Irritant; Female; Glycerol; Humans; Iodine; Iodophors; Irritants; Male; Middle Aged; Patch Tests; Pharmaceutic Aids; Polyethylene Glycols; Povidone; Povidone-Iodine; Surface-Active Agents

Topics: Adult; Anti-Infective Agents, Local; Burns, Chemical; Dermatitis, Irritant; Female; Humans; Male; Middle Aged; Povidone-Iodine