povidone-iodine and Cell-Transformation--Neoplastic

povidone-iodine has been researched along with Cell-Transformation--Neoplastic* in 2 studies

Other Studies

2 other study(ies) available for povidone-iodine and Cell-Transformation--Neoplastic

Article	Year
The use of ionized iodine for cancer prevention and eradication. Medical hypotheses, 2002, Volume: 58, Issue:4 Using an ionized iodine compound, it may be possible to transmit a weak effect of the digestive enzymes from the duodenal lumen to the cytoplasmic structures beyond the cell membrane in general organic tissues. Povidone-iodine is easily obtainable at present, and may be the most suitable ionized material for the transmission of the enzymatic effects to body tissues. Consequently, to remove certain cellular byproducts accumulated abnormally in cancerous cytoplasm, and to achieve cancer prevention and eradication, a method of using povidone-iodine, as a conceptual model, should be devised and developed in the future. Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Transformation, Neoplastic; Cytoplasm; Duodenum; Gastrointestinal Contents; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Mucosa; Lipids; Lymphatic System; Lymphocytes; Milk; Mitosis; Neoplasms; Povidone-Iodine; Protons; Solubility	2002
Assessment of somatogenotoxicity of povidone-iodine using two in vitro assays. Journal of environmental pathology and toxicology, 1980, Volume: 4, Issue:2-3 The mutagenic potential of povidone-iodine (PVP-I) and some related compounds were studied using the L5178Y mouse (TK+/-) lymphoma assay. The established mutagens ethyl methanesulfonate (EMS) and dimethylnitrosamine (DMN) were highly active in this assay, whereas PVP-I, polyvinyl pyrolidone (PVP), potassium iodide (KI), and iodine (I2) were inactive. Furthermore, in the presence of a rat liver microsomal activating fraction (S-9), PVP-I and I2 had only marginal activity as mutagens. Using the Balb/c 3T3 transformation assay we assessed the transformational capacities of these same agents and the positive mutagen N-methyl-N-nitro-N-nitrosoguanidine (MNNG). All concentrations of the compounds tested were inactive in this assay except for PVP-I (5 mg/ml) and MNNG (5 micrograms/ml). However, the response with PVP-I was only marginal. We concluded from these studies that PVP, PVP-I, KI, and I2 did not possess any biologically significant mutagenic or cell transforming ability. Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Iodine; Leukemia L5178; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Potassium Iodide; Povidone; Povidone-Iodine	1980

Article

Year

The use of ionized iodine for cancer prevention and eradication.

Medical hypotheses, 2002, Volume: 58, Issue:4

Using an ionized iodine compound, it may be possible to transmit a weak effect of the digestive enzymes from the duodenal lumen to the cytoplasmic structures beyond the cell membrane in general organic tissues. Povidone-iodine is easily obtainable at present, and may be the most suitable ionized material for the transmission of the enzymatic effects to body tissues. Consequently, to remove certain cellular byproducts accumulated abnormally in cancerous cytoplasm, and to achieve cancer prevention and eradication, a method of using povidone-iodine, as a conceptual model, should be devised and developed in the future.

Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Transformation, Neoplastic; Cytoplasm; Duodenum; Gastrointestinal Contents; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Mucosa; Lipids; Lymphatic System; Lymphocytes; Milk; Mitosis; Neoplasms; Povidone-Iodine; Protons; Solubility

2002

Assessment of somatogenotoxicity of povidone-iodine using two in vitro assays.

Journal of environmental pathology and toxicology, 1980, Volume: 4, Issue:2-3

The mutagenic potential of povidone-iodine (PVP-I) and some related compounds were studied using the L5178Y mouse (TK+/-) lymphoma assay. The established mutagens ethyl methanesulfonate (EMS) and dimethylnitrosamine (DMN) were highly active in this assay, whereas PVP-I, polyvinyl pyrolidone (PVP), potassium iodide (KI), and iodine (I2) were inactive. Furthermore, in the presence of a rat liver microsomal activating fraction (S-9), PVP-I and I2 had only marginal activity as mutagens. Using the Balb/c 3T3 transformation assay we assessed the transformational capacities of these same agents and the positive mutagen N-methyl-N-nitro-N-nitrosoguanidine (MNNG). All concentrations of the compounds tested were inactive in this assay except for PVP-I (5 mg/ml) and MNNG (5 micrograms/ml). However, the response with PVP-I was only marginal. We concluded from these studies that PVP, PVP-I, KI, and I2 did not possess any biologically significant mutagenic or cell transforming ability.

Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Iodine; Leukemia L5178; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Potassium Iodide; Povidone; Povidone-Iodine

1980