povidone-iodine and Aspergillosis

Topics: Abscess; Adult; Anti-Bacterial Agents; Antifungal Agents; Aortic Aneurysm, Abdominal; Aspergillosis; Aspergillus fumigatus; Blood Vessel Prosthesis; Combined Modality Therapy; Coronary Sinus; Coronary Vessels; Debridement; Drug Therapy, Combination; Fever; Heart Valve Prosthesis; Humans; Male; Postoperative Complications; Povidone-Iodine; Prosthesis-Related Infections; Pyrimidines; Replantation; Tomography, X-Ray Computed; Triazoles; Voriconazole

The activity of biocides against Aspergillus fumigatus is unknown. In the European guidelines to evaluate the fungicidal activity of a biocide, the critical step concerning the preparation of conidial suspensions is cumbersome and time-consuming. The aims of this study were to evaluate a simplified procedure to prepare conidial suspensions to test a biocide in comparison with the recommended one and to investigate the in vitro activity of seven biocides by the suspension neutralization method against A. fumigatus clinical isolates. The proposed simplified procedure proved reproducible, gave the same results and was quicker than that described in the European guidelines. Benzalkonium chloride (0.25 %), glutaraldehyde (1.6 %), polyvinylpyrrolidone iodine (1 % available iodine) and polyester glycol iodine (0.18 % available iodine) showed biocidal activity in

Topics: Anti-Infective Agents, Local; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Benzalkonium Compounds; Chloramines; Chlorhexidine; Chlorine; Disinfectants; Glutaral; Humans; Microbial Sensitivity Tests; Polyesters; Povidone-Iodine; Spores, Fungal; Tosyl Compounds

To determine the efficacy of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental keratitis.. Aspergillus fumigatus keratitis was induced by corneal intrastromal injection of spores in 24 healthy rabbits that were randomly divided into four groups of six rabbits each. Drugs used were 5% natamycin (standard antifungal), 0.02% polyhexamethylene biguanide (PHMB) (test drug), 1% povidone iodine (test drug), and 0.5% hydroxypropylmethyl cellulose (HPMC) (control).. The average healing times of the ulcer were 21.5 +/- 3.08 days with 5% natamycin, 27.8 +/- 2.28 days with 0.02% PHMB, 36.4 +/- 2.57 days with 1% povidone iodine, and 38.2 +/- 4.74 days with 0.5% HPMC. While no corneal perforations occurred with natamycin treatment, one perforation was noted with PHMB, three perforations were noted with povidone iodine, and five perforations were noted with controls.. Polyhexamethylene biguanide (0.02%) is a moderately effective drug for experimental Aspergillus keratitis, but 1% povidone iodine is not effective.

Topics: Animals; Anti-Infective Agents, Local; Aspergillosis; Aspergillus fumigatus; Biguanides; Corneal Stroma; Disinfectants; Drug Evaluation; Eye Infections, Fungal; Keratitis; Natamycin; Ophthalmic Solutions; Povidone-Iodine; Prospective Studies; Rabbits; Random Allocation

Three dogs with mycotic rhinitis were treated with a proprietary wound dressing product intended to produce a sustained release of povidone-iodine. All of the dogs had been refractory to other treatments. One dog had extensive soft tissue involvement, including extension into the orbital tissues, and another had evidence of involvement of the supporting bones of the nose. In all cases, the affected nasal cavity and/or frontal sinus was exposed via a dorsal approach and partial turbinectomy was performed. The wound dressing was applied and retained with a 'tie-over' dressing. The dressing was replaced every 48 to 72 hours until all exposed tissue was covered by healthy granulation tissue, at which time the rhinotomy was closed by soft tissue reconstruction. There was no evidence of recurrence of the fungal infection at follow-up times of up to 20 months postsurgery.

Topics: Administration, Cutaneous; Animals; Anti-Infective Agents, Local; Aspergillosis; Bandages; Dog Diseases; Dogs; Female; Male; Povidone-Iodine; Rhinitis; Wound Healing

Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida albicans; Eye Diseases; Microbial Sensitivity Tests; Ophthalmic Solutions; Povidone; Povidone-Iodine; Rabbits; Time Factors