povidone-iodine and Amyotrophic-Lateral-Sclerosis

Povidone-iodine (PVP-I) is generally very safe, but cases of thyroid dysfunction induced by PVP-I have been reported. The effect of long-term treatment with PVP-I on thyroid function was to be assessed. In 40 inpatients of the department of neurology, the status of the use of PVP-I preparations and their effects on serum inorganic iodine levels and thyroid functions were investigated. In 27 patients treated with PVP-I for a long term, inorganic iodine levels were significantly increased as compared to those in 13 patients without PVP-I treatment. Out of 27 patients treated with PVP-I in the long term, subclinical hypothroidism was seen in 3 patients, mild hyperthroidism was seen in 1 patient, and subclinical hyperthyroidism was suspected in 7 patients. Patients treated with PVP-I for a long time should be observed carefully for any manifestation of thyroid dysfunction.

Topics: Amyotrophic Lateral Sclerosis; Anti-Infective Agents, Local; Catheterization, Central Venous; Female; Gastrostomy; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodophors; Longitudinal Studies; Male; Middle Aged; Nasal Mucosa; Parenteral Nutrition; Povidone-Iodine; Safety; Skin Ulcer; Spinocerebellar Degenerations; Thyroid Gland; Thyrotropin; Thyroxine; Tracheotomy; Triiodothyronine; Urethra