povidone-iodine and Agranulocytosis

Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Burns; Humans; Iodine; Male; Neutropenia; Povidone; Povidone-Iodine; Sepsis

Axillary skin lesions can cause significant morbidity in patients with acute nonlymphocytic leukemia. The incidence in relation to the level of circulating granulocytes and the microbiology of 15 such lesions among 150 patients over a three year period were determined. Lesions occurred predominantly during periods of profound granulocytopenia (0-499 cells/microliter). Gram-negative bacilli were the most common pathogens isolated from these lesions. The initiation of a supervised preventive program for 84 patients over 19 months which includes the regular swabbing of each axilla with povidone-iodine cotton sticks in addition to measures to avoid skin trauma has virtually eliminated inflammatory axillary lesions in this high risk patient population.

Topics: Acute Disease; Adult; Agranulocytosis; Axilla; Bacterial Infections; Humans; Hygiene; Leukemia; Povidone-Iodine; Skin; Skin Diseases, Infectious