potassium-permanganate and Skin-Diseases

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Topics: Anti-Infective Agents, Local; Blister; Evidence-Based Medicine; Humans; Potassium Permanganate; Practice Guidelines as Topic; Skin Diseases; Wounds and Injuries

Calcinosis cutis is a disorder caused by abnormal deposits of calcium phosphate in the skin and is observed in diverse disorders. Myo-inositol hexaphosphate (InsP(6)) is a diet-dependent molecule found in all mammalian fluids and tissues, which exhibits an extraordinary capacity as a crystallization inhibitor of calcium salts.. To establish the effects of topically administered InsP(6) cream on artificially provoked dystrophic calcifications in soft tissues.. Fourteen male Wistar rats were randomly assigned into two groups: control and treated groups. Rats were fed with an InsP(6)-free or phytate diet. Plaque formation was induced by subcutaneous injection of 0.1% KMnO(4) solution. From 4 days before plaque induction to the end of the experiment, control rats were treated topically with a standard cream, whereas treated rats were treated with the same cream with 2% InsP(6) or phytate (as sodium salt). Calcification of plaques was allowed to proceed for 10 days. InsP(6) in urine was determined. The plaques were excised and weighed.. It was found that when InsP(6) was administered topically through a moisturizing cream (2% InsP(6)-rich), the plaque size and weight were notably and significantly reduced compared with the control group (1.6 +/- 1.1 mg InsP(6)-treated, 26.7 +/- 3.0 mg control). The InsP(6) urinary levels for animals treated with the InsP(6)-enriched cream were considerably and significantly higher than those found in animals treated topically with the cream without InsP(6) (16.96 +/- 4.32 mg L(-1) InsP(6)-treated, 0.06 +/- 0.03 mg L(-1) control).. This demonstrates the important capacity of InsP(6) as a crystallization inhibitor and also demonstrates that it is possible to propose topical use as a new InsP(6) administration route.

Topics: Administration, Cutaneous; Animals; Calcinosis; Male; Ointments; Phytic Acid; Potassium Permanganate; Rats; Rats, Wistar; Skin Diseases

Interleukin-1, a soluble polypeptide, plays an important role in inflammatory reactions by increasing prostaglandin E2 (PGE2) generation. Human recombinant IL-1 receptor antagonist (hrIL-1ra) is a natural inhibitor of IL-1 which blocks its activity in several inflammatory states. In these studies we found that hrIL-1ra (250 mg/ml) inhibits the generation of PGE2, as measured by RIA method, in minced mouse granuloma tissue (700 mg) treated overnight with LPS (10-1000 ng/ml) or hrIL-1 beta (0.1-10 ng/ml). In addition, we show that hrIL-1ra (250 ng/ml) strongly inhibited IL-1 alpha and IL-1 beta, as measured by ELISA method, in the minced granuloma tissue treated overnight with LPS 1 micrograms/ml or IL-1 beta (10 ng/ml). The granuloma tissue induced in mice by a dorsal subcutaneous injection (0.2 ml) of a saturated solution (1:40 dilution) of KMnO4 crystals, presented an alkaline phosphatase activity which was not inhibited by two intraperitoneal administrations of hrIL-1ra 20 micrograms/200 ml bolus injections (given at the same time as KMnO4 injection and one 24 h later). These results show for the first time that hrIL-1ra blocks PGE2, IL-1 alpha and IL-1 beta but not alkaline phosphatase activity, which is a marker in growing bone and in calcific and inflamed tissue.

Topics: Alkaline Phosphatase; Animals; Chronic Disease; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Granuloma; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lipopolysaccharides; Male; Mice; Potassium Permanganate; Radioimmunoassay; Recombinant Proteins; Sialoglycoproteins; Skin Diseases

Congo red screening of 27,052 routine biopsy specimens from 22,827 patients over a 5 1/2-year period in the Department of Pathology, University of Malaya detected 186 cases of amyloidosis. The categories of amyloidosis encountered and their prevalences in relation to each other were: systemic AL (5.9%); systemic AA (3.2%); isolated atrial (14%); primary localized cutaneous (7.5%); other primary localized deposits (3.2%); localized intratumour (58%); and dystrophic (8.6%). A third of patients with systemic AL amyloidosis had coexistent immunocyte abnormality. The commonest underlying pathology for systemic AA amyloidosis was leprosy. Notable among the types of localized amyloidosis revealed by this study were isolated atrial amyloidosis, which appeared to complicate chronic rheumatic heart disease, and intratumour amyloidosis complicating nasopharyngeal carcinoma. Other tumours in which amyloid deposits were observed included basal cell carcinoma, islet cell tumour and medullary carcinoma of the thyroid. Dystrophic amyloidosis was observed in fibrotic tissues, such as damaged cardiac valves and osteoarthritic joints. Heredofamilial amyloidosis, senile systemic amyloidosis and degenerative cerebral amyloidosis were notably absent from this study.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyloid; Amyloidosis; Cardiomyopathies; Child; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunohistochemistry; Malaysia; Microscopy, Electron; Middle Aged; Neoplasms; Potassium Permanganate; Prevalence; Skin Diseases

Postsurgical scars (cicatrixes) are the unwanted side-effects that each dermatosurgeon fears of. In dermato-abrasions of acne scars the important role in prevention of the scar occurrence has the adequate surgical treatment, in sense of the least possible traumatization and prevention of the secondary infections. Our experience shows that the 5% solution of calcium-permanganate, applied directly to freshly abraded skin, during 7-days period, followed by antibiotics and vitamins application, provide the best treatment effects.

Topics: Acne Vulgaris; Cicatrix; Dermabrasion; Humans; Postoperative Care; Potassium Permanganate; Skin Diseases

Topics: Aged; Humans; Male; Potassium Permanganate; Self Medication; Skin Diseases; Urethral Diseases; Urinary Fistula

The subcutaneous injection of small quantities of LaCl3 and CeCl3 was followed by calcification of the dorsal fascia in mice. The calcification reaction was shown by separate positive histochemical tests for calcium ions (the chloranilic acid reaction) and phosphate (the von Kossa reaction). The injection of cadmium chloride and stannous salts caused damage to and a positive von Kossa reaction in the fibres of the panniculus carnosus muscle. The significance and specificity of the histochemical tests was determined by X-ray microprobe analysis of tissues injected with the above salts and other salts known to cause either combined chloranilic acid and von Kossa positive reactions or isolated von Kossa positive reactions in mouse skin. The pathogenesis of the reactions produced by LaCl3, CeCl3 and KMnO4 was studied by applying histochemical tests to tissues recovered at timed intervals after injection. The reactions produced by LaCl3 and CeCl3 were similar and occurred in the dorsal fascia with positive VK reactions occurring first after 18 followed by positive CA reactions after 24 hr. The distribution of these reactions suggested a haematogenous origin for the constituent ions. The injection of KMnO4 in a much higher dose caused damage to the skin and particularly the fibres of the panniculus carnosus muscle. In contrast to the other salts, the calcific reaction occurred in association with these fibres, showing equally positive von Kossa and chloranilic acid reactions from the early stages.

Topics: Animals; Calcinosis; Chlorides; Fascia; Male; Mice; Potassium Permanganate; Salts; Skin; Skin Diseases

Three examples demonstrate how therapeutics (potassium permanganate and silver nitrate), improperly applied, can lead to erosions the determination of which is difficult if a relatively low water solubility causes a prolonged latency between impact and perceptible consequence. This latency can be considerably extended by a slight development of subjective symptoms of such erosions. Two of the cases show that the prescription of granulated potassium permanganate requires an accurate information of the patient.

Topics: Adult; Caustics; Health Education; Humans; Iatrogenic Disease; Male; Middle Aged; Potassium Permanganate; Self Medication; Silver Nitrate; Skin Diseases

Mineralized plaques, which develop at the site of repeated subcutaneous injections of 100 mug KMnO4/0.2 H2O in rats, were investigated by electron microscopy. The newly formed, delineated, white plaque tissue at the injection site consisted of numerous, mostly unaltered fibroblasts and collagen fibers, without participation of inflammatory cells. Some signs of cell injury were found in the center of the lesions. Numerous, irregularly distributed, small, mineralized foci were seen near the fibroblasts. These were formed by aggregation of small needle-like units (50 A in diameter and 0.05-2.0 mum long). These needle-shaped units were found either in vesicular, cell derived structures, considered to be shed cell fragments, or on collagen fibers. Intramitochondrial deposits of such needle like units were seen frequently. Fusion of smaller mineralized foci to larger plaques occured and then needle-shaped units were seen at the periphery of the electron-dense lesions. Hypotheses concerning the mechanism of experimental cutaneous calcinosis (soft tissue mineralization) are discussed and related to the findings of this study. Probable intracellular crystal deposition and mineralization in cell-derived structures were shown for the first time in topical cutaneous calcinosis.

Topics: Animals; Calcinosis; Cell Membrane; Collagen; Connective Tissue; Fibroblasts; Inclusion Bodies; Mitochondria; Potassium Permanganate; Rats; Skin; Skin Diseases

Reports of necrosis caused by quaternary ammonium compounds, such as cetrimide, are rare. The case is reported of a 77-year-old woman who was admitted to hospital for four months with cutaneous necrosis of the left foot and leg owing to the topical application of cetrimide powder.

Topics: Aged; Alkanes; Anemia; Anti-Infective Agents, Local; Cloxacillin; Debridement; Eczema; Female; Hemoglobins; Humans; Necrosis; Paraffin; Potassium Permanganate; Quaternary Ammonium Compounds; Skin Diseases; Skin Diseases, Infectious; Skin Tests; Staphylococcal Infections

Topics: Animals; Calcinosis; Calciphylaxis; Connective Tissue; Edema; Female; Mast Cells; Potassium Permanganate; Purpura; Rats; Salicylates; Skin Diseases

Topics: Age Factors; Alkaline Phosphatase; Animals; Calcinosis; Female; Fibroblasts; Glycosaminoglycans; Histocytochemistry; Male; Microscopy, Electron; Potassium Permanganate; Rats; Skin Diseases

Topics: Alkaline Phosphatase; Animals; Calcinosis; Calciphylaxis; Diphosphates; Female; Male; Potassium Permanganate; Radiography; Rats; Skin Diseases

Topics: Baths; Fusidic Acid; Humans; Ointments; Potassium Permanganate; Skin Diseases; Staphylococcal Infections