potassium-permanganate and Sepsis

Quantitative monitoring of the redox status is the foundation for redox-related treatment. The purpose of this study was to evaluate the reliability of a new depolarization curve method for plasma redox potential (ORP) monitoring.. Using the new method, we performed redox determinations for the first time under different sample-handling conditions, including redox titration experiments using KMnO4 and vitamin C and dynamic redox monitoring in burn patients. The relative ORP value (ΔORP) method (improved traditional method) was used as the reference.. The new method's better reliability, electrochemical specificity and practicability, and known group validity, which are closely associated with the redox-related pathological processes of severe burns, were confirmed. Furthermore, bidirectional change in the redox status in severe burn patients was also observed for the first time.. This simple, stable new method could be a better practical tool for making the dynamic monitoring of the redox status feasible and for providing useful quantitative information for the judgment of redox-related pathological process, thus improving corresponding individualized treatments that rely on quantitative adjustments to the redox status.

Topics: Abbreviated Injury Scale; Adult; Ascorbic Acid; Blood Chemical Analysis; Burns; Electrochemistry; Electrodes; Female; Humans; Male; Methemoglobin; Middle Aged; Monitoring, Physiologic; Oxidation-Reduction; Oxidative Stress; Potassium Permanganate; Reperfusion Injury; Reproducibility of Results; Sensitivity and Specificity; Sepsis; Shock; Uric Acid

Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in children differs from that of the adult.. A case is presented where a congenital cutaneous candidiasis was transmitted to the child during birth.. A full term newborn was exposed to a subclinical vaginal candidiasis infection, and 24 hr after birth, developed congenital cutaneous candidiasis. The etiological agent was Candida albicans, and was associated with sepsis and respiratory distress. Blood cultures, cutaneous biopsy of vesicular lesions, blood tests and lumbar puncture were performed.. Biochemistry and blood count showed a CRP of 5.7 mg/dl, leukocytosis with left shift and mild anemia. After 24 hr, the blood analyses showed an increase in a CRP (7.8 mg/dl) and increased progressively for three days; consequently, a lumbar puncture was performed. Blood culture was positive for Staphylococcus aureus. Cutaneous biopsy confirmed the cutaneous candidiasis.. The early diagnosis is essential to prevent complications derived by the Candida albicans in newborns.

Topics: Administration, Cutaneous; Administration, Oral; Anti-Infective Agents; Bacteremia; Bicarbonates; Candidiasis, Cutaneous; Candidiasis, Vulvovaginal; Cefotaxime; Cerebrospinal Fluid; Chlorhexidine; Coinfection; Early Diagnosis; Emollients; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Miconazole; Potassium Permanganate; Pregnancy; Pregnancy Complications, Infectious; Respiration Disorders; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Therapeutic Irrigation

Topics: Abortion, Criminal; Abortion, Legal; Abortion, Spontaneous; Abortion, Therapeutic; Dilatation; Embolism, Air; Equipment and Supplies; Female; Humans; Potassium Permanganate; Pregnancy; Sepsis; United Kingdom