potassium-permanganate and Pemphigus

To determine clinical curative effects of ozone therapy for pemphigus vulgaris.
 Methods: Ozone hydrotherapy was used as an aid treatment for 32 patients with pemphigus vulgaris. The hydropathic compression of potassium permanganate solution for 34 patients with pemphigus vulgaris served as a control. The main treatment for both groups were glucocorticoids and immune inhibitors. The lesions of patients, bacterial infection, usage of antibiotics, patient's satisfaction, and clinical curative effect were evaluated in the 2 groups.
 Results: There was no significant difference in the curative effect and the average length of staying at hospital between the 2 groups (P>0.05). But rate for the usage of antibiotics was significantly reduced in the group of ozone hydrotherapy (P=0.039). The patients were more satisfied in using ozone hydrotherapy than the potassium permanganate solution after 7-day therapy (P>0.05).
 Conclusion: Ozone hydrotherapy is a safe and effective aid method for pemphigus vulgaris. It can reduce the usage of antibiotics.. 目的：观察臭氧水疗辅助治疗寻常型天疱疮患者的疗效。方法：32例住院治疗的寻常型天疱疮患者使用臭氧水疗作为皮疹的辅助治疗；同期住院治疗的34例寻常型天疱疮患者采用高锰酸钾溶液湿敷或泡澡作为对照。两组患者治疗中均使用激素及免疫抑制药作为主要的治疗手段。观察患者住院期间皮疹好转情况，皮疹处细菌感染情况及抗生素的使用率，评价患者满意度，对两组疗效进行比较。结果：臭氧水疗组与对照组的疗效及平均住院日差异无统计学意义(P>0.05)；但住院期间臭氧水疗组抗生素使用率较对照组显著减少(P=0.039)，治疗第7天患者对臭氧水疗的满意度明显高于对照组(P>0.05)。结论：臭氧水疗是天疱疮安全有效的辅助治疗手段，可以减少抗生素的使用率。.

Topics: Anti-Bacterial Agents; Case-Control Studies; Dermatologic Agents; Glucocorticoids; Humans; Hydrotherapy; Length of Stay; Ozone; Pemphigus; Potassium Permanganate; Treatment Outcome