potassium-permanganate and Dermatomycoses

Two patients with cutaneous alternaria infection are presented. In both patients the skin lesions were characterized by multiple non-healing ulcers covered with dry crusts. Although the skin changes were macroscopically alike in the two patients, differences in the histology were seen. Both patients had primary debilitating diseases. A review of the literature is presented and revealed an additional ten cases of cutaneous alternariosis. Methods for the isolation of Alternaria and the susceptibility of the fungus to antimycotic drugs are presented.

Topics: Adolescent; Adult; Alternaria; Amphotericin B; Child, Preschool; Chlorquinaldol; Dermatomycoses; Female; Flucytosine; Gentian Violet; Griseofulvin; Humans; Male; Middle Aged; Mitosporic Fungi; Nystatin; Potassium Permanganate; Skin Ulcer

Aim of the paper was to report cases of Tinea imbricata, a mycosis caused by the anthropophilic dermatophyte Trichophyton concentricum, observed in 2012 in Guadalcanal, the largest of the Salomon islands.. During 2012, several cases of Tinea imbricata, called bakwa by local people, were observed in the Little Samaritan Hospital in Guadalcanal. Skin scrapings collected from three young patients were examined in Italy to confirm the clinical diagnosis. The fungus grown on culture was morphologically identified and submitted to sequencing of the ITS1-ITS2 region.. The diagnosis obtained by visual inspection of the skin lesions, characterised by concentric and lamellar plaques of scale often involving large part of the body, was confirmed mycological investigations. A prevalence of 15% of Tinea imbricata in this population was hypothesized. The fungus grown on culture was morphologically identified as Trichophyton concentricum and identification was confirmed sequencing the ITS1-ITS2 region. Patients were treated with potassium permanganate solution soaked gauze followed by colloidal sulfur and salicylic acid cream application. However, the efficacy of the antifungal treatment was difficult to evaluate due to the poor compliance of the patients and the remoteness of the villages.. Italian clinicians and mycologists should be aware of this fungal infection because the increased number of international travels and of migration rise the spread of infections previously restricted to limited geographical areas.

Topics: Antifungal Agents; Child; Colloids; Dermatomycoses; Female; Humans; Male; Medication Adherence; Melanesia; Potassium Permanganate; Salicylic Acid; Sulfur; Tinea; Trichophyton

Fusarium spp. are fungi found throughout the world and can cause a great variety of skin infections, mainly in immunodepressed individuals. We present a case of skin infection with Fusarium sp. which manifested as painful superficial ulcers on the legs of an immunocompetent female patient, who had applied <> as a <> for leg pain. The condition was cured with oral itraconazole and local treatments.

Topics: Aged; Antifungal Agents; Dermatomycoses; Drug Therapy, Combination; Female; Fusarium; Humans; Immunocompetence; Itraconazole; Ketoconazole; Leg Ulcer; Mud Therapy; Potassium Permanganate; Soil Microbiology; Venous Insufficiency

The drugs used in the treatment of superficial mycoses include substances with an indirect affect on the organisms such as the keratolytics as well as antifungal compounds. The antifungals include specific inhibitory compounds such as the polyene or imidazole antibiotics and substances with a wider spectrum of antiseptic activity. High cure rates (80-90%) can be achieved by most specific antifungals although this can be affected by the host response and the location of the infection. The orally active antifungals used in superficial disease, ketoconazole and griseofulvin, can be used in conditions unresponsive or inaccessible to topical therapy, such as chronic superficial candidosis and tinea capitis. However, the treatment of onychomycosis, particularly affecting toe nails, is highly unsatisfactory. There is therefore an important place for new drugs and new methods of applying them in the treatment of superficial (local) mycoses.

Topics: Administration, Oral; Administration, Topical; Amphotericin B; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Etretinate; Female; Griseofulvin; Humans; Imidazoles; Ketoconazole; Nystatin; Potassium Permanganate; Resorcinols; Salicylates; Salicylic Acid; Suppositories; Tretinoin; Vagina

Fungal infections of the skin in children are common and may mimic many other dermatoses. Diagnostic techniques are simple and inexpensive; Wood's light examination, KOH wet mounts, and preferably fungal culture should be performed on all suspected lesions.

Topics: Acetates; Adolescent; Aluminum; Arthrodermataceae; Candida albicans; Candidiasis; Candidiasis, Oral; Child, Preschool; Dermatomycoses; Humans; Onychomycosis; Potassium Permanganate; Tinea Capitis; Tinea Pedis; Tinea Versicolor; Undecylenic Acids