potassium-permanganate and Acute-Disease

Bacterial colonization and infection are important factors in compromised wound healing, particularly in chronic wounds. Although "best practice" for controlling these factors currently is not defined, systemic antibiotics are generally accepted as the preferred choice for treating infection, provided ischemia does not reduce their bioavailability. However, widespread use of systemic and topical antibiotics is associated with the emergence of resistant bacterial strains such as methicillin-resistant Staphylococcus aureus. Colonization of wounds presents a double problem--potentially delayed healing and a potential source for cross-contamination. The judicious use of dressings, notably those containing certain antiseptic agents, can be a valuable option to control infection and promote healing. A review of the literature underscores the importance of considering the antiseptic route as part of a concerted approach to wound management and infection control.

Topics: Acute Disease; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Benchmarking; Biofilms; Biological Availability; Chlorhexidine; Chronic Disease; Colony Count, Microbial; Evidence-Based Medicine; Honey; Humans; Infection Control; Iodine Compounds; Potassium Permanganate; Risk Factors; Severity of Illness Index; Silver Compounds; Skin Care; Sodium Hypochlorite; Wound Healing; Wound Infection

No clinical trials have been conducted in India on the efficacy of parenteral antibacterials to treat footrot in sheep. In addition, there are no studies worldwide on the efficacy of parenteral antibacterials to treat chronic footrot. Sixty two sheep with acute footrot and 30 sheep with chronic footrot from 7 villages in Kashmir, India were recruited into two separate trials. Sheep with acute footrot were allocated to one of three treatments using stratified random sampling: long acting parenteral oxytetracycline, long acting parenteral enrofloxacin and topical application of potassium permanganate solution (a traditional treatment used by sheep farmers in India). In a quasi pre-post intervention design, sheep with chronic footrot that had not responded to treatment with potassium permanaganate were randomly allocated to treatment with one of the two parenteral antibacterials mentioned above. Sheep with acute footrot were treated on day 0 and those with chronic footrot on days 0, 3, 6 and 9. Sheep were monitored for up to 28 days after treatment. Time to recovery from lameness and initial healing of lesions was assessed using Kaplan-Meier survival curves, nonparametric log-rank and Wilcoxon sign-rank tests.. There was significant correlation in recovery from lameness and presence of healing lesions in sheep with acute (r = 0.94) or chronic (r = 0.98) footrot. Sheep with acute footrot which were treated with parenteral antibacterials had a significantly more rapid recovery from lameness and had healing lesions (median = 7 days) compared with those treated with topical potassium permanganate solution (less than 50% recovered in 28 days). The median time to recovery in sheep with chronic footrot treated with either antibacterial was 17 days; this was significantly lower than the median of 75 days lame before treatment with antibacterials. The median time to recovery for both acute and chronic footrot increased as the severity of lesions increased. There was no difference in time to recovery by age, body condition score, duration lame, or presence of pus in the foot within acute and chronically affected sheep.. We conclude that use of parenteral antibacterials to treat sheep lame with either acute or chronic footrot in India is highly effective. This is likely to improve welfare and give economic benefits to the farmers.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacterial Infections; Chronic Disease; Delayed-Action Preparations; Enrofloxacin; Female; Fluoroquinolones; Foot Diseases; India; Lameness, Animal; Male; Oxytetracycline; Potassium Permanganate; Sheep; Sheep Diseases

A 73-year-old female patient presented with acute very painful perianal ulcerations. She reported using various ointments and later potassium permanganate baths because of maceration of the rima ani as a manifestation of her psoriasis vulgaris. Suddenly after starting the potassium permanganate baths, necrotic areas developed with then became ulcerated. After excluding the relevant differential diagnostic considerations, we diagnosed ulcerations caused by a caustic burn from potassium permanganate. After stooping potassium permanganate baths and employing modern moist wound therapy, we attained complete healing after 8 months of treatment.

Topics: Acute Disease; Aged; Baths; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Potassium Permanganate; Proctitis; Skin Ulcer

Topics: Acute Disease; Adult; Anal Canal; Anti-Inflammatory Agents, Non-Steroidal; Baths; Combined Modality Therapy; Diet; Female; Fissure in Ano; Humans; Length of Stay; Male; Middle Aged; Potassium Permanganate

Severe potassium permanganate poisoning (more than 10 g of potassium permanganate) is invariably associated with massive systemic upset and death. Multiple organ damage has been recognized as an inevitable consequence of such an overdose, although pancreatitis has not been previously reported. Death due to cardiovascular collapse and profound hypotension is a common end point in those who reach hospital, but the pathogenesis is uncertain. We report a case of haemorrhagic pancreatitis following an overdose of potassium permanganate and suggest that this complication may be an unrecognized factor contributing to the extremely high mortality rate associated with this condition.

Topics: Acute Disease; Aged; Hemorrhage; Humans; Male; Pancreatitis; Potassium Permanganate; Suicide

We report a case of corrosive burns to the mouth, oesophagus and trachea in a three-year-old boy who ingested potassium permanganate crystals. The pathophysiology and treatment options are discussed. The prevention of accidental ingestion could be improved with careful packaging of the solid tablet or crystalline forms.

Topics: Acute Disease; Burns, Chemical; Child, Preschool; Combined Modality Therapy; Crystallization; Esophagus; Humans; Male; Mouth; Potassium Permanganate; Trachea

Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Humans; Injections; Male; Manganese; Potassium Permanganate; Suicide, Attempted

Topics: Acute Disease; Adolescent; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Laparotomy; Poisoning; Potassium Permanganate

The structural aspects of SH antigen-containing particles were investigated. These studies confirmed the existence of a large spherical particle (ca. 43 nm) and smaller (ca. 20 nm) rod- and sphere-shaped particles. The large particle consists of an outer and inner membrane and a core of "nucleic acid" as seen by positive staining techniques. The outer membrane of the large particle appears to be similar to that of the 20-nm diameter spheres and rods known to possess the SH antigen.

Topics: Acute Disease; Antigens; Carrier State; Chronic Disease; Hepatitis B; Hepatitis B virus; Humans; Microscopy, Electron; Phosphotungstic Acid; Potassium Permanganate; Staining and Labeling; Uranium

Topics: Acute Disease; Albumins; Alpha-Globulins; Beta-Globulins; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Electrophoresis; Encephalomalacia; Female; gamma-Globulins; Gold; Humans; Ischemic Attack, Transient; Male; Potassium Permanganate; Pressure