potassium-iodate and Thyroid-Neoplasms

Prerequisite. Since the advent of nuclear energy, industry and weapons, a possibility of radiation events i.e. incidents and accidents had emerged. Given the presence of radioactive iodine as part of environmental contamination, the response of authorities and medical services consists, in particular, in carrying out the emergency iodine prophylaxis among specialists and general population. And along with the fact that emergency iodine prophylaxis is a generally accepted measure in radiation events accompanied by the release of radioactive iodine, some methods of its implementation were and remain in certain sources and instructions/recommendations contradictory and even false. Such inconsistency increases the potential risks of health effects of radioactive iodine and exacerbates the sense of fear and uncertainty among the population involved in the incident.. to consider and review the essence of emergency iodine prophylaxis during radiation events, physiological aspects of iodine metabolism in the body, properties of individual iodine prophylaxis agents that are recommended, and to justify the rationality of using some of them along with absurdity/inadmissibility of others; substantiate the creation of a unified preventive information strategy regarding the event in order to reduce anxiety and other negative psychological consequences among the affected population.. The review was performed by searching the abstract and scientometric databases and printed publications.. In the event of serious radiation events at nuclear power plants and industry facilities, radioactive iodine is highly likely to enter the environment. With the threat of radioactive iodine incorporation or with its incorporation that has already begun, it is absolutely necessary to carry out the emergency iodine prophylaxis. Such prevention should be carried out with stable iodine preparations such as potassium iodide or potassium iodate in special pharmaceutical formulas. Dosing of drugs in age and population groups should be carried out by specialists in radiation medicine and radiation safety in accordance with internationally recognized guidelines. The use of iodinecontaining food additives, iodine solution for external use and Lugol's solution is categorically unacceptable due to complete ineffectiveness, impracticality of implementation, and sometimes due to the threat of serious harm to health.. Clear preparedness plans for possible radiation accidents and incidents, as well as successfullyimplemented appropriate preventive measures, including emergency iodine prophylaxis, are crucial for the effective and successful response to such events. Emergency iodine prophylaxis during radiation events should be carried out exclusively under the guidance of specialists in radiation medicine and radiation safety using special pharmaceutical formulas of potassium iodide or potassium iodate in doses recognized by the international scientific community. Other means of emergency iodine prophylaxis, including «handicraft»/home preparations, are absolutely unacceptable. Implementation of this protective measure should be accompanied by a coordinated information campaign in order to minimize purely radiation risks and to preserve the psychological well-being of the population.. Peredumova. Z momentu poiavy iadernoï energetyky, promyslovosti ta zbroï isnuie ĭmovirnist' radiatsiĭnykh podiĭ - intsydentiv ta avariĭ. Za umovy naiavnosti radioaktyvnogo ĭodu u skladi ekologichnykh zabrudnen' reaguvannia organiv vlady i medychnykh sluzhb poliagaie, zokrema, u provedenni sered fakhivtsiv ta naselennia v tsilomu avariĭnoï ĭodnoï profilaktyky. I poriad z tym, shcho avariĭna ĭodna profilaktyka ie zagal'novyznanym zakhodom pry radiatsiĭnykh podiiakh, shcho suprovodzhuiut'sia vykydom radioaktyvnogo ĭodu, deiaki metody ïï provedennia buly ĭ zalyshaiut'sia u pevnykh dzherelakh i nastanovakh rekomendatsiiakh superechlyvymy i navit' khybnymy. Podibna neuzgodzhenist'zbil'shuie potentsiĭni ryzyky medychnykh efektiv radioaktyvnogo ĭodu i pidvyshchuie pochuttia strakhu i nevyznachenosti sered zaluchenogo do intsydentu naselennia.Meta: rozglianuty sutnist' avariĭnoï ĭodnoï profilaktyky pry radiatsiĭnykh podiiakh, fiziologichni aspekty obminu ĭodu v organizmi, vlastyvosti okremykh zasobiv ĭodnoï profilaktyky, iaki rekomenduiut'sia, ta obґruntuvaty ratsional'nist' zastosuvannia odnykh z nykh i bezgluzdist' neprypustymist' inshykh; obgruntuvaty stvorennia iedynoï preventyvnoï informatsiĭnoï strategiï shchodo zakhodu z metoiu zmenshennia tryvozhnosti ta inshykh negatyvnykh psykhologichnykh naslidkiv sered postrazhdalogo naselennia.Materialy ta metody. Ogliad vykonano shliakhom poshuku u referatyvnykh ĭ naukometrychnykh bazakh ta drukovanykh vydanniakh. Rezul'taty. Pry serĭoznykh radiatsiĭnykh podiiakh na pidpryiemstvakh iadernoï energetyky ta promyslovosti u navkolyshnie seredovyshche z vysokoiu ĭmovirnistiu nadkhodyt' radioaktyvnyĭ ĭod. Pry zagrozi inkorporatsiï radioaktyvnogo ĭodu abo pry ĭogo inkorporatsiï, iaka vzhe pochalasia, neodminno neobkhidne provedennia avariĭnoï ĭodnoï profilaktyky. Taku profilaktyku slid provodyty preparatamy stabil'nogo ĭodu u vygliadi kaliiu ĭodydu abo kaliiu ĭodatu u spetsial'nykh farmatsevtychnykh formakh vypusku. Dozuvannia preparativ u vikovykh i populiatsiĭnykhgrupakh zdiĭsniuiet'sia vidpovidno do mizhnarodnovyznanykh nastanov spetsialistamy z radiatsiĭnoï medytsyny ta radiatsiĭnoï bezpeky. Zastosuvannia ĭodovmisnykh kharchovykh dobavok, rozchynu ĭodu dlia zovnishn'ogo zastosuvannia i rozchynu Liugolia kategorychno neprypustyme cherez povnu neefektyvnist', nereal'nist' vykonannia, a inkoly - z ogliadu na zagrozu tiazhkoï shkody zdorov’iu.Vysnovky. Chitki plany gotovnosti shchodo mozhlyvykh radiatsiĭnykh avariĭ ta intsy

Topics: Humans; Iodine; Iodine Radioisotopes; Pharmaceutical Preparations; Potassium Iodide; Radioactive Hazard Release; Thyroid Neoplasms

The effects of different doses of potassium iodate (KIO

Topics: bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Iodates; MicroRNAs; Neoplasm Invasiveness; Potassium Compounds; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thyroid Neoplasms