potassium chloride has been researched along with Myocardial Ischemia in 67 studies
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 7.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 3.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| " oxygen/ozone mixture were tested on arrhythmias induced by i) ischemia; ii) ischemia/reperfusion; iii) aconitine (15microg/kg/i." | 3.76 | Antiarrhythmic effect of acute oxygen-ozone administration to rats. ( Capodanno, P; Cervone, C; D'Amico, M; Di Filippo, C; di Ronza, C; Luongo, C; Marfella, R; Rossi, C; Rossi, F, 2010) |
| "We previously demonstrated that pinacidil does not affect Na(+)(i) accumulation, cellular energy depletion, or acidosis during myocardial ischemia, but dramatically improves the cationic/energetic status during reperfusion." | 3.72 | Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection. ( Digerness, SB; Guo, LL; Pike, MM; Takayama, E, 2004) |
| "1 mM MgCl2 to iohexol on cardiac electrophysiology and hemodynamics (iohexol+electrolytes = IPE)." | 3.69 | Cardiac effects of coronary arteriography with electrolyte addition to iohexol. A study in dogs with and without heart failure. ( Jacobsen, EA; Kløw, NE; Pedersen, HK; Refsum, H, 1994) |
| " In our study we compared myocardial protection in isolated coronary bypass with a short period of ischemia using low dosage HTK and cold crystalloid cardioplegia." | 2.71 | Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection. ( Akay, T; Arslan, A; Aslamaci, S; Gultekin, B; Ozkan, S; Sezgin, A; Tasdelen, A; Uguz, E, 2005) |
| " Nifedipine at a dosage of 200 micrograms or placebo was added to each 1000 ml of St." | 2.67 | Cardioprotection by nifedipine cardioplegia during coronary artery surgery. ( Haider, W; Laczkovics, A; Moritz, A; Trubel, W; Zwoelfer, W, 1994) |
| "Flecainide was equi-effective at low and high concentrations, with VF incidence reduced from 92% to 17% (p < 0." | 1.31 | Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts. ( Curtis, MJ; Farkas, A, 2002) |
| "Ten bradykinin-pretreated hearts received a 10-minute infusion of 0." | 1.30 | Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways. ( Feng, J; Rosenkranz, ER, 1999) |
| "Effects on ischemia-induced arrhythmias could not be explained by changes in blood pressure or heart rate." | 1.28 | Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration. ( Abraham, S; MacLeod, BA; McGough, J; Saint, KM; Walker, MJ; Yoshida, N, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 41 (61.19) | 18.2507 |
| 2000's | 21 (31.34) | 29.6817 |
| 2010's | 3 (4.48) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Marklund, M | 1 |
| Singh, G | 1 |
| Greer, R | 1 |
| Cudhea, F | 1 |
| Matsushita, K | 1 |
| Micha, R | 1 |
| Brady, T | 1 |
| Zhao, D | 1 |
| Huang, L | 1 |
| Tian, M | 1 |
| Cobb, L | 1 |
| Neal, B | 1 |
| Appel, LJ | 1 |
| Mozaffarian, D | 1 |
| Wu, JHY | 1 |
| Wu, J | 1 |
| Liu, X | 1 |
| Wang, M | 1 |
| Wang, X | 1 |
| Su, S | 1 |
| Li, WC | 1 |
| Gao, H | 1 |
| Gao, J | 1 |
| Wang, ZJ | 1 |
| Jacob, M | 1 |
| Paul, O | 1 |
| Mehringer, L | 1 |
| Chappell, D | 1 |
| Rehm, M | 1 |
| Welsch, U | 1 |
| Kaczmarek, I | 1 |
| Conzen, P | 1 |
| Becker, BF | 1 |
| Di Filippo, C | 1 |
| Cervone, C | 1 |
| Rossi, C | 1 |
| di Ronza, C | 1 |
| Marfella, R | 1 |
| Capodanno, P | 1 |
| Luongo, C | 1 |
| Rossi, F | 1 |
| D'Amico, M | 1 |
| Imura, H | 1 |
| Lin, H | 1 |
| Griffiths, EJ | 1 |
| Suleiman, MS | 2 |
| Ji, B | 1 |
| Feng, Z | 1 |
| Liu, J | 1 |
| Long, C | 1 |
| Ikizler, M | 1 |
| Dernek, S | 1 |
| Sevin, B | 1 |
| Maxey, TS | 1 |
| Kural, T | 1 |
| Yotsumoto, G | 2 |
| Jeschkeit-Schubbert, S | 1 |
| Funcke, C | 1 |
| Kuhn-Régnier, F | 1 |
| Fischer, JH | 1 |
| Czerski, LW | 1 |
| Szweda, PA | 1 |
| Szweda, LI | 1 |
| Wang, J | 1 |
| Zhou, X | 1 |
| Zhao, Y | 1 |
| Tang, H | 1 |
| Hu, Y | 1 |
| Nishikawa, Y | 1 |
| Stepp, DW | 1 |
| Merkus, D | 1 |
| Jones, D | 1 |
| Chilian, WM | 1 |
| Takayama, E | 1 |
| Guo, LL | 1 |
| Digerness, SB | 1 |
| Pike, MM | 1 |
| Dias, RR | 1 |
| Stolf, NA | 1 |
| Dalva, M | 1 |
| Dias, AR | 1 |
| Moreira, LF | 1 |
| Oliveira, SA | 1 |
| Wei, J | 1 |
| Chang, CY | 1 |
| Chuang, YC | 1 |
| Su, SH | 1 |
| Lee, KC | 1 |
| Tung, DY | 1 |
| Lee, SL | 1 |
| Lee, WC | 1 |
| Arslan, A | 1 |
| Sezgin, A | 1 |
| Gultekin, B | 1 |
| Ozkan, S | 1 |
| Akay, T | 1 |
| Uguz, E | 1 |
| Tasdelen, A | 1 |
| Aslamaci, S | 1 |
| Mühlfeld, C | 1 |
| Urru, M | 1 |
| Rümelin, R | 1 |
| Mirzaie, M | 1 |
| Schöndube, F | 1 |
| Richter, J | 5 |
| Dörge, H | 1 |
| Amark, K | 1 |
| Berggren, H | 1 |
| Björk, K | 1 |
| Ekroth, A | 1 |
| Ekroth, R | 1 |
| Nilsson, K | 1 |
| Sunnegårdh, J | 1 |
| Yamamoto, H | 1 |
| Ichikawa, H | 1 |
| Yamamoto, F | 1 |
| Karck, M | 2 |
| Ziemer, G | 1 |
| Zoeller, M | 1 |
| Schulte, S | 1 |
| Juergens, KD | 1 |
| Weisser, H | 1 |
| Haverich, A | 1 |
| Kolocassides, KG | 1 |
| Galiñanes, M | 1 |
| Hearse, DJ | 2 |
| Baker, EJ | 1 |
| Boerboom, LE | 1 |
| Olinger, GN | 1 |
| Baker, JE | 1 |
| Sheridan, FM | 1 |
| Saldanha, C | 1 |
| Dart, AM | 1 |
| Du, XJ | 1 |
| Trubel, W | 1 |
| Zwoelfer, W | 1 |
| Moritz, A | 1 |
| Laczkovics, A | 1 |
| Haider, W | 1 |
| Choong, YS | 2 |
| Cottier, DS | 2 |
| Edgar, SG | 1 |
| Pridjian, AK | 1 |
| Bove, EL | 1 |
| Bolling, SF | 2 |
| Childs, KF | 1 |
| Brosamer, KM | 1 |
| Lupinetti, FM | 1 |
| Pedersen, HK | 1 |
| Jacobsen, EA | 1 |
| Refsum, H | 1 |
| Kløw, NE | 1 |
| Kupriyanov, VV | 1 |
| St Jean, M | 1 |
| Xiang, B | 1 |
| Butler, KW | 1 |
| Deslauriers, R | 1 |
| Chen, W | 1 |
| Steenbergen, C | 1 |
| Levy, LA | 1 |
| Vance, J | 1 |
| London, RE | 1 |
| Murphy, E | 1 |
| Kober, IM | 1 |
| Obermayr, RP | 1 |
| Spieckermann, PG | 1 |
| Lawton, JS | 1 |
| Harrington, GC | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 3 |
| Menasché, P | 1 |
| Mouas, C | 1 |
| Grousset, C | 1 |
| Yamazaki, I | 1 |
| Yano, Y | 1 |
| Kondo, J | 1 |
| Matsumoto, A | 1 |
| Kurata, H | 1 |
| Soma, T | 1 |
| Fukuhiro, Y | 1 |
| Chocron, S | 1 |
| Alwan, K | 1 |
| Toubin, G | 1 |
| Kantelip, B | 1 |
| Clement, F | 1 |
| Kantelip, JP | 1 |
| Etievent, JP | 1 |
| Gavin, JB | 1 |
| Poltronieri, R | 1 |
| Cevese, A | 1 |
| Bregu, R | 1 |
| Motta, A | 1 |
| Zancanaro, C | 1 |
| Bernocchi, P | 1 |
| Moffatt, AC | 1 |
| Dihmis, WC | 1 |
| Caputo, M | 1 |
| Hutter, JA | 1 |
| Angelini, GD | 1 |
| Bryan, AJ | 1 |
| Schmiedl, A | 4 |
| Schnabel, PA | 3 |
| Süzer, O | 2 |
| Diri, E | 1 |
| Konukoğlu, D | 1 |
| Ozüner, Z | 2 |
| Moriyama, Y | 1 |
| Yamaoka, A | 1 |
| Taira, A | 1 |
| Köseoğlu, S | 1 |
| Hachida, M | 1 |
| Lu, H | 1 |
| Ohkado, A | 1 |
| Hoshi, H | 1 |
| Gu, H | 1 |
| Nakanishi, T | 1 |
| Koyanagi, H | 1 |
| Doğan, R | 2 |
| Sarigül, A | 1 |
| Isbir, S | 1 |
| Farsak, B | 2 |
| Tuncer, M | 1 |
| Kilinç, K | 2 |
| Demircin, M | 1 |
| Shanewise, JS | 1 |
| Kosinski, AS | 1 |
| Coto, JA | 1 |
| Jones, EL | 1 |
| Jayawant, AM | 1 |
| Stephenson, ER | 2 |
| Baumgarten, CM | 1 |
| Rohs, TJ | 1 |
| Kilgore, KS | 1 |
| Georges, AJ | 1 |
| Jayawant, M | 1 |
| Askenasy, N | 2 |
| Navon, G | 2 |
| Headrick, JP | 1 |
| McKirdy, JC | 1 |
| Willis, RJ | 1 |
| Gerber, SH | 1 |
| Heyer, C | 1 |
| Krüger, C | 1 |
| Hagl, S | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Ibrahim, MF | 1 |
| Venn, GE | 1 |
| Young, CP | 1 |
| Chambers, DJ | 1 |
| Feng, J | 1 |
| Rosenkranz, ER | 1 |
| Symons, JD | 1 |
| Rendig, SV | 1 |
| Stebbins, CL | 1 |
| Longhurst, JC | 1 |
| Mahmoudian, M | 1 |
| Shafiei, M | 1 |
| Mirkhani, H | 1 |
| Omrani, GR | 1 |
| Selim Isbir, C | 1 |
| Aydin, M | 1 |
| Stoletzki, S | 1 |
| Suzuki, S | 1 |
| Kusano, KF | 1 |
| Goto, Y | 1 |
| Obata, T | 1 |
| Ebihara, A | 1 |
| Yamanaka, Y | 1 |
| Kausch Blecken von Schmeling, H | 1 |
| Marten, K | 1 |
| Farkas, A | 1 |
| Curtis, MJ | 1 |
| Saint, KM | 1 |
| Abraham, S | 1 |
| MacLeod, BA | 1 |
| McGough, J | 1 |
| Yoshida, N | 1 |
| Walker, MJ | 1 |
| Vivi, A | 1 |
| Tassini, M | 1 |
| Schwalb, H | 1 |
| Borman, JB | 1 |
| Uretzky, G | 1 |
| Amrani, M | 1 |
| Shirvani, R | 1 |
| Allen, NJ | 1 |
| Ledingham, S | 1 |
| Yacoub, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
1 review available for potassium chloride and Myocardial Ischemia
| Article | Year |
|---|---|
Unexpected drug effects on autonomic function during myocardial ischaemia.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous Sy | 1993 |
6 trials available for potassium chloride and Myocardial Ischemia
| Article | Year |
|---|---|
Myocardial protection related to magnesium content of cold blood hyperkalemic cardioplegic solutions in CABG.
Topics: Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; China; Cold Temperature; Coronary Art | 2002 |
Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection.
Topics: Adult; Aged; Cardioplegic Solutions; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Fema | 2005 |
Myocardial metabolism is better preserved after blood cardioplegia in infants.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Aorta; Bicarbonates; Blood; Blood Glucose; Calcium Chloride; Car | 2006 |
Cardioprotection by nifedipine cardioplegia during coronary artery surgery.
Topics: Arrhythmias, Cardiac; Bicarbonates; Calcium Chloride; Cardiac Output; Cardiac Output, Low; Cardiople | 1994 |
Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting.
Topics: Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Artery Bypass; Crystalloid Solution | 1998 |
A clinical comparative study between crystalloid and blood-based St Thomas' hospital cardioplegic solution.
Topics: Adenine Nucleotides; Aged; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Artery B | 1999 |
60 other studies available for potassium chloride and Myocardial Ischemia
| Article | Year |
|---|---|
Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study.
Topics: Adult; Aged; Blood Pressure; Cardiovascular Diseases; China; Diet, Sodium-Restricted; Female; Humans | 2020 |
Reduction of Cold Ischemic Injury with the Addition of Compound Glycyrrhizin in HTK Solution in a Mouse Heart Transplantation Model.
Topics: Animals; Anti-Inflammatory Agents; Cold Ischemia; Drug Evaluation, Preclinical; Glucose; Glycyrrhizi | 2020 |
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Gap Junc | 2019 |
Albumin augmentation improves condition of guinea pig hearts after 4 hr of cold ischemia.
Topics: Animals; Cardiac Output; Cell Adhesion; Coronary Vessels; Edema; Endothelium, Vascular; Glucose; Gui | 2009 |
Antiarrhythmic effect of acute oxygen-ozone administration to rats.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Male; Myocardial Ischemia; Oxygen; | 2010 |
Controlled hyperkalemic reperfusion with magnesium rescues ischemic juvenile hearts by reducing calcium loading.
Topics: Age Factors; Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart Rate; Hyperkalemia; | 2011 |
Improved myocardial function with the addition of pinacidil to custadiol.
Topics: Animals; Blood Pressure; Coronary Circulation; Creatine Kinase; Glucose; Heart; Hypothermia, Induced | 2002 |
Total recovery of heart grafts of non-heart-beating donors after 3 hours of hypothermic coronary oxygen persufflation preservation in an orthotopic pig transplantation model.
Topics: Animals; Diacetyl; Glucose; Heart Arrest; Heart Transplantation; Heart-Lung Machine; Hypothermia, In | 2003 |
Dissociation of cytochrome c from the inner mitochondrial membrane during cardiac ischemia.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome c Group; Cytosol; Intra | 2003 |
Myocardial protection of immature rabbits: polarizing versus depolarizing.
Topics: Aging; Animals; Bicarbonates; Body Water; Calcium Chloride; Cardiotonic Agents; Coronary Circulation | 2003 |
In vivo role of heme oxygenase in ischemic coronary vasodilation.
Topics: Animals; Carbon Monoxide; Coronary Circulation; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Endothe | 2004 |
Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection.
Topics: Animals; Calcium; Chlorides; Heart Ventricles; In Vitro Techniques; Membrane Proteins; Myocardial Is | 2004 |
Inclusion of lidocaine in cardioplegic solutions provides additional myocardial protection.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Creatine Kinas | 2004 |
Successful heart transplantation after 13 hours of donor heart ischemia with the use of HTK solution: a case report.
Topics: Adolescent; Glucose; Heart; Heart Transplantation; Humans; Male; Mannitol; Myocardial Ischemia; Pota | 2005 |
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
Topics: Animals; Decanoic Acids; Glucose; Hydroxy Acids; Mannitol; Mitochondria; Myocardial Ischemia; Myocyt | 2006 |
[Diltiazem abolishes the effect of ryanodine in St. Thomas' Hospital cardioplegic solution on the post-ischemic functional recovery].
Topics: Animals; Bicarbonates; Calcium; Calcium Channels; Calcium Chloride; Diltiazem; Heart Arrest, Induced | 1995 |
Protection of the chronic hypoxic immature rat heart during global ischemia.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Blood Gas Analysis; Calcium Chloride; Cardioplegic So | 1995 |
Ischemic preconditioning, cardioplegia or both?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Heart Arrest, Induced; Magnesium; Mal | 1994 |
Tolerance of the developing heart to ischemia: impact of hypoxemia from birth.
Topics: Age Factors; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Crea | 1995 |
The vasoactive effect of serotonin on canine coronary arteries after ischemia and reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vasospasm; Cor | 1994 |
Cardioplegia and vascular injury. Dissociation of the effects of ischemia from those of the cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Endothelium, Vascular; Heart Arrest | 1994 |
Protective effects of oxygenated St. Thomas' Hospital cardioplegic solution during ischaemic cardiac arrest: improved function, metabolism and ultrastructure.
Topics: Analysis of Variance; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Drug Evaluati | 1993 |
Developmental differences in myocardial protection in response to 5'-nucleotidase inhibition.
Topics: 5'-Nucleotidase; Aging; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardiac Output; C | 1994 |
Cardiac effects of coronary arteriography with electrolyte addition to iohexol. A study in dogs with and without heart failure.
Topics: Animals; Blood Pressure; Calcium Chloride; Cardiac Output; Cardiac Output, Low; Coronary Angiography | 1994 |
Contractile dysfunction caused by normothermic ischaemia and KCL arrest in the isolated pig heart: a 31P NMR study.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Energy Metabolism; Hydrogen-Ion Concentratio | 1995 |
Measurement of free Ca2+ in sarcoplasmic reticulum in perfused rabbit heart loaded with 1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid by 19F NMR.
Topics: Animals; Calcium; Chelating Agents; Cytosol; Diastole; Egtazic Acid; Fluorescent Dyes; Fluorine; Hea | 1996 |
How beneficial is the reduction of edema formation by polyethylene glycol during cardioplegic arrest?
Topics: Animals; Blood Pressure; Cardioplegic Solutions; Coronary Circulation; Edema; Glucose; Heart; Heart | 1996 |
Myocardial protection with pinacidil cardioplegia in the blood-perfused heart.
Topics: Animals; Blood; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Dose-R | 1996 |
Is potassium channel opening an effective form of preconditioning before cardioplegia?
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circ | 1996 |
[Comparison between intermittent retrograde cold blood cardioplegia and retrograde crystalloid cardioplegia].
Topics: Aged; Bicarbonates; Calcium Chloride; Cardiopulmonary Bypass; Creatine Kinase; Female; Heart Arrest, | 1996 |
[The experimental study of myocardial protection for warm myocardial ischemia in an isolated rat heart: the effect of a calcium antagonist].
Topics: Animals; Bicarbonates; Calcium Channel Blockers; Calcium Chloride; Cardioplegic Solutions; Diltiazem | 1996 |
Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Heart | 1996 |
Cardioplegic protection of hearts with pre-arrest ischaemic injury: effect of glucose, aspartate, and lactobionate.
Topics: Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; Disacchar | 1995 |
Biochemical and morphological changes in isolated rabbit hearts after prolonged hypothermic ischaemia: comparison of two cardioplegic solutions.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Ki | 1995 |
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
Topics: Adenosine Triphosphate; Aged; Bicarbonates; Biomarkers; Blood; Calcium Chloride; Cardioplegic Soluti | 1997 |
Cellular edema and alterations in metabolite content in the ischemic and reperfused canine heart following different forms of cardiac arrest.
Topics: Animals; Aorta; Bicarbonates; Calcium Chloride; Cardiomyopathies; Cardioplegic Solutions; Constricti | 1996 |
The role of isocolloidoosmotic synthetic colloid addition to St. Thomas Hospital cardioplegic solution for cardioprotection in isolated perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Colloids; C | 1997 |
Experimental study of cardiac lymph dynamics and edema formation in ischemia/reperfusion injury--with reference to the effect of hyaluronidase.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Body Temperature; Body Water; Calcium Chloride; Cardi | 1998 |
Human albumin enriched St. Thomas Hospital cardioplegic solution increases reperfusion injury in isolated perfused rat hearts.
Topics: Albumins; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Fem | 1998 |
Effectiveness of ischemic preconditioning on long-term myocardial preservation.
Topics: Animals; Calcium; Cardioplegic Solutions; Coronary Circulation; Creatine Kinase; Glucose; Heart; In | 1998 |
Beneficial effect of captopril against ischaemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 1998 |
Prevention of cell swelling with low chloride St. Thomas' Hospital solution improves postischemic myocardial recovery.
Topics: Animals; Atrioventricular Node; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; C | 1998 |
Postischemic function and protein kinase C signal transduction.
Topics: Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Bicarbonates; Calcium Chloride; Cardioplegi | 1998 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Intracellular volumes and membrane permeability in rat hearts during prolonged hypothermic preservation with St Thomas and University of Wisconsin solutions.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cell Membrane Permeability; Cryopre | 1998 |
Functional and metabolic effects of extracellular magnesium in normoxic and ischemic myocardium.
Topics: Adenosine Triphosphate; Animals; Calcium; Cytosol; Depression, Chemical; Extracellular Space; Magnes | 1998 |
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fev | 1999 |
Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways.
Topics: Animals; Bicarbonates; Bradykinin; Calcium Chloride; Coronary Circulation; Diastole; Heart Arrest, I | 1999 |
Microvascular and myocardial contractile responses to ischemia: influence of exercise training.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Carbon D | 2000 |
Effects of different vasodilators on human internal mammary artery in vitro.
Topics: Ethanolamines; Female; Humans; In Vitro Techniques; Isoproterenol; Isosorbide Dinitrate; Male; Mamma | 1999 |
The protective effect of lisinopril on membrane-bound enzymes in myocardial preservation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chloride; Calcium-Transport | 2000 |
Intercalated clear cells or pale cells in the sinus node of canine hearts? An ultrastructural study.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Female; Glucose; Heart; Heart | 2000 |
Effects of repetitive brief ischemia on contractile efficiency and oxygen cost of contractility in dog heart.
Topics: Animals; Calcium; Cardiac Volume; Coronary Circulation; Dogs; Energy Metabolism; In Vitro Techniques | 2000 |
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart.
Topics: Animals; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Heart; Hydroxyl Radical; Hydr | 2001 |
Swelling of capillary endothelial cells and cardiomyocytes in the ischaemic myocardium of artificially arrested canine hearts.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Capillaries; Cardioplegic Solutions | 2001 |
Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Fl | 2002 |
Different preservation of myocardial capillary endothelial cells and cardiomyocytes during and after cardioplegic ischemia (25 degrees C) of canine hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endothelium, Vascular; Female | 2002 |
Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration.
Topics: Animals; Arrhythmias, Cardiac; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium; | 1992 |
The effectiveness of University of Wisconsin solution on prolonged myocardial protection as assessed by phosphorus 31-nuclear magnetic resonance spectroscopy and functional recovery.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bicarbonates; Body Water; Calcium Chloride; | 1992 |
Enhancement of low coronary reflow improves postischemic myocardial function.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coronary Circulatio | 1992 |