potassium chloride has been researched along with Mitral Incompetence in 2 studies
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Braathen, B | 1 |
Jeppsson, A | 1 |
Scherstén, H | 1 |
Hagen, OM | 1 |
Vengen, Ø | 1 |
Rexius, H | 1 |
Lepore, V | 1 |
Tønnessen, T | 1 |
Olesen, KH | 1 |
Valentin, N | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 20 |
Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 6.0 |
Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 1.9 |
Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 24 |
Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 5.7 |
Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 3.0 |
Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | .03 |
Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
Intervention | ng/mL (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 18.8 |
Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
Intervention | ng/mL (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 9.65 |
Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
Intervention | % LV volume (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | -0.06 |
Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | minutes (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 340 |
Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
Intervention | days (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 3 |
Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 47 |
Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | hours (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 10.5 |
Cold Blood Cardioplegia | 11.4 |
1 trial available for potassium chloride and Mitral Incompetence
Article | Year |
---|---|
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study.
Topics: Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Chi-Square Distribution; Creatine K | 2011 |
1 other study available for potassium chloride and Mitral Incompetence
Article | Year |
---|---|
Total exchangeable potassium, sodium and chloride in patients with severe valvular heart disease during preparation for cardiac surgery.
Topics: Adult; Aortic Valve Insufficiency; Atrial Fibrillation; Bicarbonates; Blood Proteins; Body Compositi | 1973 |