potassium chloride has been researched along with Injury, Myocardial Reperfusion in 122 studies
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 7.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| "This study aimed to investigate the myocardial protective effect of liquid sodium phosphocreatine cardiac arrest in extracorporeal circulation surgery treating infants with atrial septal defects." | 3.96 | The myocardial protective effect of monosodium phosphate cardioplegia in cardiopulmonary bypass in infants with an atrial septal defect. ( Wang, J; Yang, F; Zhai, B, 2020) |
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 3.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| " In study 1 (constant flow perfusion) 8 groups (n = 6 hearts per group) were studied: (1) 40 minutes of global ischemia; (2) 2 minutes of St Thomas' Hospital infusion and 40 minutes of ischemia; (3) multidose (every 10 minutes) infusions of St Thomas' Hospital solution during 40 minutes of ischemia; (4) 2 minutes of esmolol infusion and 40 minutes of ischemia; (5) multidose (every 10 minutes) esmolol infusions during 40 minutes of ischemia; (6) continuous infusion of esmolol for 40 minutes during coronary perfusion; (7) intermittent (4 x 10 minutes) ischemia with ventricular fibrillation; and (8) intermittent (4 x 10 minutes) ischemia preceded by intermittent esmolol administration." | 3.71 | Myocardial protection: the efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent. ( Bessho, R; Chambers, DJ, 2001) |
| "The effects of 5-(N,N-dimethyl)amiloride, a potent and specific Na(+)-H+ exchange inhibitor, were investigated in isolated perfused rabbit hearts subjected to ischemia and reperfusion." | 3.69 | Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. ( Abe, T; Akita, T; Hotta, Y; Kodama, I; Koike, A; Murase, M; Takeya, K; Toyama, J, 1996) |
| " The purpose of this study was to evaluate clinical efficacy of the TWBC in combination with B-HTK for myocardial protection." | 2.69 | [Efficacy of terminal warm blood cardioplegia in combination with Bretschneider-HTK solution for myocardial protection]. ( Endoh, M; Hachida, M; Ishitoya, H; Kitamura, M; Koyanagi, H; Morishita, A, 1999) |
| "After selective cardiac arrest with Bretschneider, captopril-treated hearts showed improved hemodynamics compared to control and the other treatment groups." | 1.40 | Acute hemodynamic effects of angiotensin- converting enzyme inhibition after prolonged cardiac arrest with Bretschneider's solution. ( Dhein, S; Hoyer, A; Kempfert, J; Mohr, FW; Pritzwald-Stegmann, P, 2014) |
| "Pinacidil-treated hearts had significantly better recovery of left ventricular developed pressure (47 +/- 3." | 1.32 | K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution. ( Feng, J; Li, H; Rosenkranz, ER, 2003) |
| "Flecainide was equi-effective at low and high concentrations, with VF incidence reduced from 92% to 17% (p < 0." | 1.31 | Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts. ( Curtis, MJ; Farkas, A, 2002) |
| "Treatment with diltiazem improved the recovery of left ventricular developed pressure to 96." | 1.29 | Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts. ( Abe, T; Akita, T; Kato, S; Kodama, I; Toyama, J, 1993) |
| "Pretreatment with coenzyme Q10 given intraperitoneally improved aortic flow, cardiac output, stroke volume, coronary flow, and heart rate." | 1.29 | Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts. ( Ali, K; Fukaya, Y; Furukawa, Y; Morimoto, M, 1993) |
| "Adenosine treatment during initial reperfusion increased coronary flow (percentage of baseline +/- standard error of the mean) from 57% +/- 4% in control and 45% +/- 3% in hearts with hyperkalemic reperfusion to 79% +/- 3% and 83% +/- 5% in hearts with hyperkalemic reperfusion also treated with, respectively, 1 mmol/L adenosine and 5 mmol/L adenosine (p < 0." | 1.29 | Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine. ( Bosnjak, ZJ; Graf, BM; Habazettl, H; Palmisano, BW; Roerig, DL; Stowe, DF, 1996) |
| "Effects on ischemia-induced arrhythmias could not be explained by changes in blood pressure or heart rate." | 1.28 | Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration. ( Abraham, S; MacLeod, BA; McGough, J; Saint, KM; Walker, MJ; Yoshida, N, 1992) |
| " Post-ischemic recovery of AoF (%AoF) showed the bell-shaped dose-response curve, and the optimal dose was 3 microM (Exp." | 1.28 | [The effects of protease inhibitor upon the ischemia-reperfusion injury]. ( Kawashima, Y; Kinoshita, H; Nakajima, N; Ohashi, T; Shibata, T; Shimada, Y; Yamamoto, F, 1992) |
| "When acadesine was given as an in vivo pretreatment (100 mg/kg i." | 1.28 | Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat. ( Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM, 1992) |
| " In dose-response studies (with 0, 3,000, 6,000, 12,000, 30,000, or 60,000 units/kg; n = 8 per group), maximum recovery of LVDP was obtained with the administration of 12,000 units/kg of PEG-SOD." | 1.28 | PEG-SOD and myocardial protection. Studies in the blood- and crystalloid-perfused rabbit and rat hearts. ( Ezrin, A; Galiñanes, M; Hearse, DJ; Qiu, Y, 1992) |
| " Furthermore, a dose-response curve showed that a glucose concentration of 20 mmol/L gave no better recovery than 0 mmol/L, and glucose in St." | 1.28 | St. Thomas' Hospital cardioplegic solution. Beneficial effect of glucose and multidose reinfusions of cardioplegic solution. ( Du Toit, EF; Dunne, T; King, LM; Opie, LH; Owen, P; Reichart, B; von Oppell, UO, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (4.92) | 18.7374 |
| 1990's | 73 (59.84) | 18.2507 |
| 2000's | 22 (18.03) | 29.6817 |
| 2010's | 20 (16.39) | 24.3611 |
| 2020's | 1 (0.82) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, F | 1 |
| Wang, J | 1 |
| Zhai, B | 1 |
| Wang, D | 1 |
| Zhang, X | 2 |
| Qu, D | 1 |
| Han, J | 1 |
| Meng, F | 1 |
| Xu, M | 1 |
| Zheng, Q | 1 |
| Schaefer, M | 1 |
| Gebhard, MM | 2 |
| Gross, W | 1 |
| Li, WC | 1 |
| Gao, H | 1 |
| Gao, J | 1 |
| Wang, ZJ | 1 |
| Sung, SY | 1 |
| Lin, CY | 1 |
| Song, JY | 1 |
| Tsai, YT | 1 |
| Kao, CH | 1 |
| Lee, CY | 1 |
| Lin, YC | 1 |
| Hsu, PS | 1 |
| Tsai, CS | 1 |
| Hoyer, A | 2 |
| Kempfert, J | 2 |
| Pritzwald-Stegmann, P | 2 |
| Mohr, FW | 2 |
| Dhein, S | 2 |
| Chen, Y | 1 |
| Liu, J | 1 |
| Li, S | 1 |
| Yan, F | 1 |
| Xue, Q | 1 |
| Wang, H | 1 |
| Sun, P | 1 |
| Long, C | 1 |
| Symons, R | 1 |
| Cork, TE | 1 |
| Lakshmanan, MN | 1 |
| Evers, R | 1 |
| Davies-Venn, C | 1 |
| Rice, KA | 1 |
| Thomas, ML | 1 |
| Liu, CY | 1 |
| Kappler, S | 1 |
| Ulzheimer, S | 1 |
| Sandfort, V | 1 |
| Bluemke, DA | 1 |
| Pourmorteza, A | 1 |
| Maruyama, Y | 2 |
| Chambers, DJ | 11 |
| Bockeria, LA | 1 |
| Movsesyan, RR | 1 |
| Ryabtsev, DV | 1 |
| Grigoryants, TR | 1 |
| Wu, F | 1 |
| Wei, GZ | 1 |
| Li, WJ | 1 |
| Liu, B | 1 |
| Zhou, JJ | 1 |
| Wang, HC | 1 |
| Gao, F | 1 |
| Aarsaether, E | 1 |
| Stenberg, TA | 1 |
| Jakobsen, Ø | 1 |
| Busund, R | 1 |
| Koch, A | 1 |
| Loganathan, S | 1 |
| Radovits, T | 1 |
| Sack, FU | 1 |
| Karck, M | 3 |
| Szabó, GB | 1 |
| Xue, HM | 1 |
| He, GW | 2 |
| Huang, JH | 1 |
| Yang, Q | 1 |
| Lee, S | 1 |
| Huang, CS | 1 |
| Kawamura, T | 1 |
| Shigemura, N | 1 |
| Stolz, DB | 1 |
| Billiar, TR | 1 |
| Luketich, JD | 1 |
| Nakao, A | 1 |
| Toyoda, Y | 1 |
| Imura, H | 1 |
| Lin, H | 1 |
| Griffiths, EJ | 1 |
| Suleiman, MS | 3 |
| Wei, L | 2 |
| Wu, RB | 2 |
| Yang, CM | 2 |
| Zheng, SY | 2 |
| Yu, XY | 2 |
| Vinten-Johansen, J | 1 |
| Viana, FF | 1 |
| Shi, WY | 1 |
| Hayward, PA | 1 |
| Larobina, ME | 1 |
| Liskaser, F | 1 |
| Matalanis, G | 1 |
| Lima, ML | 1 |
| Fiorelli, AI | 1 |
| Vassallo, DV | 1 |
| Batista, PR | 1 |
| Simoes, FV | 1 |
| Fiorim, J | 1 |
| Stefanon, I | 1 |
| Pinheiro, BB | 1 |
| Stolf, NA | 1 |
| Gomes, OM | 1 |
| Trescher, K | 1 |
| Hasun, M | 1 |
| Baumgartner, A | 1 |
| Dietl, W | 1 |
| Wolfsberger, M | 1 |
| Hallström, S | 1 |
| Podesser, BK | 1 |
| Fuchs, F | 1 |
| Messmer, K | 1 |
| Kuppe, H | 1 |
| Habazettl, H | 3 |
| McCully, JD | 1 |
| Bessho, R | 2 |
| Ebel, D | 1 |
| Preckel, B | 3 |
| You, A | 1 |
| Müllenheim, J | 1 |
| Schlack, W | 3 |
| Thämer, V | 3 |
| Köksal, C | 1 |
| Süzer, O | 3 |
| Bozkurt, AK | 1 |
| Köseoğlu, S | 3 |
| Bull, DA | 1 |
| Maurer, J | 1 |
| Feng, J | 1 |
| Li, H | 1 |
| Rosenkranz, ER | 1 |
| Dobson, GP | 1 |
| Jones, MW | 1 |
| Camara, AK | 1 |
| Chen, Q | 2 |
| An, J | 2 |
| Novalija, E | 2 |
| Riess, ML | 1 |
| Rhodes, SS | 1 |
| Stowe, DF | 4 |
| Saini, HK | 1 |
| Dhalla, NS | 1 |
| Dong, YY | 1 |
| Wu, M | 1 |
| Yim, AP | 1 |
| Obata, T | 2 |
| Pisarenko, OI | 1 |
| Studneva, IM | 1 |
| Lakomkin, VL | 1 |
| Timoshin, AA | 1 |
| Kapelko, VI | 1 |
| Yuan, S | 1 |
| You, L | 1 |
| Zhu, L | 1 |
| Li, G | 1 |
| Liu, M | 1 |
| Dong, C | 2 |
| Tian, X | 1 |
| Liu, H | 1 |
| Ziemer, G | 1 |
| Zoeller, M | 1 |
| Schulte, S | 2 |
| Juergens, KD | 1 |
| Weisser, H | 1 |
| Haverich, A | 2 |
| Kolocassides, KG | 1 |
| Galiñanes, M | 7 |
| Hearse, DJ | 13 |
| Baker, EJ | 1 |
| Boerboom, LE | 3 |
| Olinger, GN | 3 |
| Baker, JE | 3 |
| Bolling, SF | 5 |
| Olszanski, DA | 2 |
| Childs, KF | 2 |
| Gallagher, KP | 4 |
| Ning, XH | 1 |
| Sheridan, FM | 1 |
| Yuan, SM | 1 |
| Zhu, LB | 1 |
| Li, GS | 1 |
| Liu, MH | 1 |
| Yu, YF | 1 |
| Wang, DQ | 1 |
| Li, JC | 1 |
| Luo, J | 1 |
| Menasché, P | 1 |
| Termignon, JL | 1 |
| Pradier, F | 1 |
| Grousset, C | 1 |
| Mouas, C | 1 |
| Alberici, G | 1 |
| Weiss, M | 1 |
| Piwnica, A | 1 |
| Bloch, G | 1 |
| Möllhoff, T | 1 |
| Sukehiro, S | 1 |
| Borgers, M | 1 |
| Vandeplassche, G | 1 |
| Van Belle, H | 1 |
| Van Aken, H | 1 |
| Flameng, W | 1 |
| Görge, G | 1 |
| Erbel, R | 1 |
| Dobbertin, A | 1 |
| Hänggi, M | 1 |
| Hake, U | 1 |
| Meyer, J | 1 |
| Chong, YS | 1 |
| Cottier, DS | 1 |
| Gavin, JB | 2 |
| Aoki, M | 1 |
| Nomura, F | 1 |
| Mayer, JE | 1 |
| Boban, M | 1 |
| Graf, BM | 2 |
| Kampine, JP | 1 |
| Bosnjak, ZJ | 2 |
| Akita, T | 2 |
| Abe, T | 4 |
| Kato, S | 1 |
| Kodama, I | 2 |
| Toyama, J | 2 |
| Amrani, M | 4 |
| Allen, NJ | 2 |
| O'Shea, J | 1 |
| Corbett, J | 1 |
| Dunn, MJ | 1 |
| Tadjkarimi, S | 1 |
| Theodoropoulos, S | 1 |
| Pepper, J | 1 |
| Yacoub, MH | 3 |
| Ali, K | 1 |
| Morimoto, M | 1 |
| Fukaya, Y | 1 |
| Furukawa, Y | 1 |
| Powell, SR | 1 |
| Aiuto, L | 1 |
| Hall, D | 1 |
| Tortolani, AJ | 1 |
| Palmisano, BW | 1 |
| Roerig, DL | 1 |
| Lawton, JS | 1 |
| Sepic, JD | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 1 |
| Hachida, M | 2 |
| Ookado, A | 1 |
| Nonoyama, M | 1 |
| Koyanagi, H | 2 |
| Choong, YS | 1 |
| Schnabel, PA | 3 |
| Kilkowski, A | 1 |
| Koike, A | 1 |
| Hotta, Y | 1 |
| Takeya, K | 1 |
| Murase, M | 1 |
| Bical, OM | 1 |
| Gerhardt, MF | 1 |
| Paumier, D | 1 |
| Gaillard, D | 1 |
| Landais, P | 1 |
| Fromes, Y | 1 |
| Foiret, JC | 1 |
| Trivin, F | 1 |
| Vanetti, A | 1 |
| Irtun, O | 1 |
| Sørlie, D | 1 |
| Moffatt, AC | 1 |
| Dihmis, WC | 2 |
| Caputo, M | 2 |
| Hutter, JA | 1 |
| Angelini, GD | 2 |
| Bryan, AJ | 2 |
| Katayama, O | 2 |
| Ledingham, S | 2 |
| Jayakumar, J | 2 |
| Smolenski, RT | 1 |
| Severs, N | 2 |
| Rothery, S | 2 |
| Goodwin, AT | 1 |
| Gray, CC | 1 |
| Chester, AH | 1 |
| Yotsumoto, G | 1 |
| Moriyama, Y | 1 |
| Yamaoka, A | 1 |
| Taira, A | 1 |
| Ozüner, Z | 1 |
| Doğan, R | 3 |
| Sarigül, A | 2 |
| Isbir, S | 2 |
| Farsak, B | 3 |
| Tuncer, M | 2 |
| Kilinç, K | 2 |
| Demircin, M | 1 |
| Liu, K | 1 |
| Sekine, S | 1 |
| Goto, Y | 2 |
| Iijima, K | 1 |
| Kondon, K | 1 |
| Matsukawa, M | 1 |
| Tian, J | 1 |
| Wu, W | 1 |
| Zhang, B | 1 |
| Chen, L | 1 |
| Zhang, H | 1 |
| Zhao, H | 1 |
| Song, X | 1 |
| Han, G | 1 |
| Sakata, J | 1 |
| Morishita, K | 1 |
| Ito, T | 1 |
| Koshino, T | 1 |
| Kazui, T | 1 |
| Cisowski, M | 1 |
| Bochenek, A | 1 |
| Kucewicz, E | 1 |
| Wnuk-Wojnar, AM | 1 |
| Morawski, W | 1 |
| Skalski, J | 1 |
| Grzybek, H | 1 |
| Voigtländer, J | 1 |
| Mühlbayer, D | 1 |
| Bernard, M | 1 |
| Caus, T | 1 |
| Sciaky, M | 1 |
| Lan, C | 1 |
| Cozzone, PJ | 1 |
| Aomine, M | 1 |
| Yamanaka, Y | 1 |
| Morishita, A | 1 |
| Kitamura, M | 1 |
| Ishitoya, H | 1 |
| Endoh, M | 1 |
| Isbir, CS | 1 |
| Ayd1n, M | 1 |
| Keeling, IM | 1 |
| Obermayr, RP | 1 |
| Schneider, B | 1 |
| Spieckermann, PG | 1 |
| Farkas, A | 1 |
| Curtis, MJ | 1 |
| Heisner, JS | 1 |
| Camara, A | 1 |
| Varadarajan, SG | 1 |
| Schelling, P | 1 |
| Schmiedl, A | 2 |
| Richter, J | 2 |
| Saint, KM | 1 |
| Abraham, S | 1 |
| MacLeod, BA | 1 |
| McGough, J | 1 |
| Yoshida, N | 1 |
| Walker, MJ | 1 |
| Yacoub, M | 2 |
| Shibata, T | 2 |
| Yamamoto, F | 2 |
| Ohashi, T | 2 |
| Shimada, Y | 2 |
| Nakajima, N | 1 |
| Kinoshita, H | 1 |
| Kawashima, Y | 2 |
| Yamamoto, H | 1 |
| Ichikawa, H | 1 |
| Ishikawa, T | 1 |
| Kagisaki, K | 1 |
| Kumada, Y | 1 |
| Iannettoni, MD | 2 |
| Bove, EL | 4 |
| Fox, MH | 2 |
| Groh, MA | 1 |
| Harvey, DM | 1 |
| Braimbridge, MV | 7 |
| Kim, YD | 1 |
| Fomsgaard, JS | 1 |
| Heim, KF | 1 |
| Ramwell, PW | 1 |
| Thomas, G | 1 |
| Kagan, E | 1 |
| Moore, SP | 1 |
| Coughlin, SS | 1 |
| Kuwahara, M | 1 |
| Analouei, A | 1 |
| Qiu, Y | 2 |
| Breda, MA | 1 |
| Drinkwater, DC | 1 |
| Laks, H | 1 |
| Bhuta, S | 1 |
| Ho, B | 1 |
| Kaczer, E | 1 |
| Sebastian, JL | 1 |
| Chang, P | 1 |
| Bullough, D | 2 |
| Mullane, KM | 2 |
| Ezrin, A | 1 |
| Yang, YJ | 1 |
| Liu, JJ | 1 |
| Gu, XH | 1 |
| Casley, DJ | 1 |
| Nayler, WG | 1 |
| Tian, GH | 1 |
| Mainwood, GW | 1 |
| Biro, GP | 1 |
| Smith, KE | 1 |
| Butler, KW | 1 |
| Lawrence, D | 1 |
| Deslauriers, R | 1 |
| von Oppell, UO | 1 |
| Du Toit, EF | 1 |
| King, LM | 1 |
| Owen, P | 1 |
| Dunne, T | 1 |
| Reichart, B | 1 |
| Opie, LH | 1 |
| Ohgoshi, Y | 1 |
| Futaki, S | 1 |
| Taku, H | 1 |
| Kawaguchi, O | 1 |
| Suga, H | 1 |
| Bach, F | 1 |
| Bartels, U | 1 |
| Ramsauer, B | 1 |
| Bretschneider, HJ | 1 |
| Kosker, S | 2 |
| Yamada, M | 1 |
| Jupp, RA | 2 |
| Crowther, A | 1 |
| Ledingham, SJ | 1 |
| Lachno, DR | 1 |
| Shvilkin, AV | 1 |
| Levitskiĭ, DO | 1 |
| Serebriakova, LI | 1 |
| Tskitishvili, OV | 1 |
| Sadretdinov, SM | 1 |
| Takahashi, A | 4 |
| Sakai, A | 1 |
| Baharakakis, S | 1 |
| Manzanera, G | 1 |
| Smith, LD | 1 |
| Pearson, PJ | 1 |
| Schaff, HV | 1 |
| Vanhoutte, PM | 1 |
| Zweng, TN | 1 |
| Pridjian, AK | 1 |
| Astras, G | 1 |
| Manning, AS | 1 |
| Tutterová, M | 1 |
| Vavrínková, H | 1 |
| Janata, V | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
1 review available for potassium chloride and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Aprotinin and preservation of myocardial function after ischemia-reperfusion injury.
Topics: Animals; Aprotinin; Bicarbonates; Calcium Chloride; Coronary Artery Bypass; Fibrinolysis; Humans; Ma | 2003 |
8 trials available for potassium chloride and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Morphometric evaluation on myocardial protection of cold crystalloid versus warm blood cardioplegia.
Topics: Bicarbonates; Blood; Body Temperature; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Byp | 1995 |
Myocardial protection of cold crystalloid and warm blood cardioplegia. A comparative study.
Topics: Adult; Aortic Valve; Bicarbonates; Blood; Body Temperature; Calcium Chloride; Cardiopulmonary Bypass | 1994 |
Effects of two different crystalloid cardioplegic solutions assessed by myocardial pH, tissue lactate content and energy metabolism.
Topics: Acid-Base Equilibrium; Aged; Bicarbonates; Biopsy; Calcium Chloride; Cardioplegic Solutions; Energy | 1996 |
Warm blood hyperkalaemic reperfusion ('hot shot') prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery.
Topics: Adenosine Triphosphate; Amino Acids; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; | 1998 |
The use of exogenous creatine phosphate for myocardial protection in patients undergoing coronary artery bypass surgery.
Topics: Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Coronary Artery Bypass; | 1996 |
[Efficacy of terminal warm blood cardioplegia in combination with Bretschneider-HTK solution for myocardial protection].
Topics: Aged; Blood; Cardioplegic Solutions; Cardiopulmonary Bypass; Female; Glucose; Heart Arrest, Induced; | 1999 |
Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol). Results of a clinical study.
Topics: Adult; Aged; Aorta; Arrhythmias, Cardiac; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Co | 1991 |
Comparison of standard (non-oxygenated) vs. oxygenated St. Thomas' Hospital cardioplegic solution No. 2 (Plegisol).
Topics: Adolescent; Adult; Aged; Bicarbonates; Biopsy; Calcium Chloride; Coronary Artery Bypass; Creatine Ki | 1990 |
113 other studies available for potassium chloride and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The myocardial protective effect of monosodium phosphate cardioplegia in cardiopulmonary bypass in infants with an atrial septal defect.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Cardiopulmonary Bypass; Cardiotonic Agents; Case-Cont | 2020 |
Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest.
Topics: Animals; Apoptosis; Biomarkers; Cardioplegic Solutions; Cardiotonic Agents; Cytokines; Disease Model | 2018 |
The efficiency of heart protection with HTK or HTK-N depending on the type of ischemia.
Topics: Animals; Calcium; Cardioplegic Solutions; Female; Gap Junctions; Glucose; Guinea Pigs; Heart Arrest, | 2019 |
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Gap Junc | 2019 |
Myocardial protection in donor heart preservation: a comparison between Bretschneider's histidine-tryptophan-ketoglutarate solution and cold blood cardioplegia.
Topics: Adult; Cardioplegic Solutions; Chi-Square Distribution; Cold Temperature; Female; Glucose; Heart Arr | 2014 |
Acute hemodynamic effects of angiotensin- converting enzyme inhibition after prolonged cardiac arrest with Bretschneider's solution.
Topics: Adenosine Triphosphate; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhib | 2014 |
Histidine-tryptophan-ketoglutarate solution with added ebselen augments myocardial protection in neonatal porcine hearts undergoing ischemia/reperfusion.
Topics: Animals; Antioxidants; Azoles; Glucose; Heart; Heart Arrest, Induced; Isoindoles; Mannitol; Myocardi | 2015 |
Dual-contrast agent photon-counting computed tomography of the heart: initial experience.
Topics: Animals; Cicatrix; Contrast Media; Disease Models, Animal; Dogs; Feasibility Studies; Heart; Image I | 2017 |
Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; D | 2008 |
eComment: myocardial protection: efficacy of a novel magnesium-basedcardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; D | 2008 |
Low extracellular K+ increases intracellular Ca2+ oscillation and injury by activating the reverse mode Na+-Ca2+ exchanger and inhibiting the Na+, K+ ATPase in rat cardiomyocytes.
Topics: Animals; Calcium; Calcium Signaling; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Heart Ventri | 2010 |
Mechanoenergetic function and troponin T release following cardioplegic arrest induced by St Thomas' and histidine-tryptophan-ketoglutarate cardioplegia--an experimental comparative study in pigs.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Bypass; | 2009 |
Deferoxamine, the newly developed iron chelator LK-614 and N-alpha-acetyl-histidine in myocardial protection.
Topics: Animals; Cold Ischemia; Deferoxamine; Glucose; Heart Transplantation; Histidine; Hydroxamic Acids; I | 2010 |
New strategy of endothelial protection in cardiac surgery: use of enhancer of endothelial nitric oxide synthase.
Topics: Animals; Arginine; Benzodioxoles; Bicarbonates; Blotting, Western; Bradykinin; Calcium Chloride; Car | 2010 |
Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Apoptosis; Cold Ischemia; Creatine K | 2010 |
Controlled hyperkalemic reperfusion with magnesium rescues ischemic juvenile hearts by reducing calcium loading.
Topics: Age Factors; Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart Rate; Hyperkalemia; | 2011 |
Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart.
Topics: Animals; Apoptosis; Cold Ischemia; Female; Glucose; Hemoglobins; Interleukin-1beta; Mannitol; Myocar | 2011 |
Cardioprotective effects of low-dose cyclosporin A added to histidine-tryptophan-ketoglutarate cardioplegia solution prior to total myocardial ischemia: an in vitro rabbit heart study.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Cardiotonic Agents; Cyclosporine; Glucose; | 2011 |
Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury.
Topics: Animals; Blood Substitutes; Cold Ischemia; Down-Regulation; Glucose; Hemoglobins; Interleukin-6; Man | 2011 |
Ischaemic postconditioning: does cardioplegia influence protection?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Disease Models, Animal; Heart Arrest, | 2012 |
Editorial comment: myocardial protection with postconditioning in cardiac surgery: the importance of the model.
Topics: Animals; Bicarbonates; Calcium Chloride; Heart Arrest, Induced; Ischemic Postconditioning; Magnesium | 2012 |
Custodiol versus blood cardioplegia in complex cardiac operations: an Australian experience.
Topics: Aged; Australia; Cardiac Surgical Procedures; Cardiotonic Agents; Chi-Square Distribution; Female; G | 2013 |
Deleterious effect of hypothermia in myocardial protection against cold ischemia: a comparative study in isolated rat hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cold Ischemia; Disaccharides; Edema | 2012 |
New HTK-N46B cardioplegia provides superior protection during ischemia/reperfusion in failing hearts.
Topics: Animals; Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Disease Models, Animal; Gl | 2013 |
Initial reperfusion with magnesium after cardioplegic arrest attenuates myocardial reperfusion injury.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Glucose; Guinea Pi | 2002 |
Oxygenated multidose delivery of crystalloid esmolol cardioplegia as an alternative to high potassium cardioplegia.
Topics: Adrenergic beta-Antagonists; Animals; Cardioplegic Solutions; Heart Arrest, Induced; Humans; Myocard | 2002 |
Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Bicarbonates; Cardioplegic Solutions; He | 2002 |
Cardioprotection by sevoflurane against reperfusion injury after cardioplegic arrest in the rat is independent of three types of cardioplegia.
Topics: Adenosine; Allopurinol; Anesthetics, Inhalation; Animals; Cardioplegic Solutions; Glucose; Glutathio | 2002 |
Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts.
Topics: Amrinone; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Enoxi | 2002 |
K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulat | 2003 |
Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation.
Topics: Adenosine; Animals; Bicarbonates; Blood Flow Velocity; Body Water; Calcium Chloride; Cardioplegic So | 2004 |
Comparison of hyperkalemic cardioplegia with altered [CaCl2] and [MgCl2] on [Ca2+]i transients and function after warm global ischemia in isolated hearts.
Topics: Animals; Calcium; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Cytosol; Diastole; | 2004 |
Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia-reperfusion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2005 |
Effect of hypoxia-reoxygenation on endothelial function in porcine cardiac microveins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bicarbonates; Biologica | 2006 |
Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxy | 2006 |
Human recombinant extracellular-superoxide dismutase type C improves cardioplegic protection against ischemia/reperfusion injury in isolated rat heart.
Topics: Animals; Bicarbonates; Calcium Chloride; Cattle; Hemodynamics; Humans; In Vitro Techniques; Ischemia | 1994 |
Protection of the chronic hypoxic immature rat heart during global ischemia.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Blood Gas Analysis; Calcium Chloride; Cardioplegic So | 1995 |
Ischemic preconditioning, cardioplegia or both?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Heart Arrest, Induced; Magnesium; Mal | 1994 |
Tolerance of the developing heart to ischemia: impact of hypoxemia from birth.
Topics: Age Factors; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Crea | 1995 |
Stunning, preconditioning, and functional recovery after global myocardial ischemia.
Topics: Animals; Bicarbonates; Blood Pressure; Calcium Chloride; Cardioplegic Solutions; Heart Arrest, Induc | 1994 |
The vasoactive effect of serotonin on canine coronary arteries after ischemia and reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vasospasm; Cor | 1994 |
Experimental evaluation of Celsior, a new heart preservation solution.
Topics: Abdomen; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cold Temperature; Disaccha | 1994 |
Influence of superoxide dismutase on reperfusion injury in donor hearts preserved with Bretschneider-HTK cardioplegic solution.
Topics: Animals; Dogs; Glucose; Heart Transplantation; Inclusion Bodies; Mannitol; Mitochondria, Heart; Myoc | 1993 |
Isolated in-vitro perfusion of pig hearts obtained from the abattoir: an alternative to animal experiments?
Topics: Abattoirs; Animal Testing Alternatives; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Soluti | 1994 |
Myocardial protection during prolonged ischaemic cardiac arrest: experimental evaluation of three crystalloid cardioplegic solutions.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Electrolytes; Evaluation Studies as | 1994 |
Interactions between preischemic hypothermia and cardioplegic solutions in the neonatal lamb heart.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Glucose; | 1994 |
Contraction uncoupling with butanedione monoxime versus low calcium or high potassium solutions on flow and contractile function of isolated hearts after prolonged hypothermic perfusion.
Topics: Animals; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Diacetyl; Guinea Pigs; Hear | 1994 |
Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts.
Topics: Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Calcium Chloride; Cardioplegic Solutions; C | 1993 |
Role of catalase and heat shock protein on recovery of cardiac endothelial and mechanical function after ischemia.
Topics: Amitrole; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Catalase; Endothelium, Va | 1993 |
Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts.
Topics: Animals; Aorta; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coenzymes; C | 1993 |
Zinc supplementation enhances the effectiveness of St. Thomas' Hospital No. 2 cardioplegic solution in an in vitro model of hypothermic cardiac arrest.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Arrest, Induced; Hypothermia, | 1995 |
Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine.
Topics: Acetylcholine; Adenosine; Animals; Cardioplegic Solutions; Coronary Circulation; Guinea Pigs; Hemody | 1996 |
Myocardial protection with potassium-channel openers is as effective as St. Thomas' solution in the rabbit heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Ci | 1996 |
Effect of HTK solution for myocardial preservation.
Topics: Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Glucose; Heart; Heart Arrest, Induced; | 1996 |
Functional, metabolic and ultrastructure evidence for improved myocardial protection during severe ischaemic stress with MBS, a new crystalloid cardioplegic solution.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutio | 1996 |
Adverse effects of crystalloid cardioplegia and slow cooling for protection of immature rat hearts.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bicarbonates; Calcium Chloride; Cardiomegaly; Cardiopl | 1996 |
Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy.
Topics: Acidosis; Adenosine Triphosphate; Amiloride; Animals; Bicarbonates; Calcium; Calcium Chloride; Cardi | 1996 |
High cardioplegic perfusion pressure entails reduced myocardial recovery.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiopulmo | 1997 |
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
Topics: Adenosine Triphosphate; Aged; Bicarbonates; Biomarkers; Blood; Calcium Chloride; Cardioplegic Soluti | 1997 |
Effect of cardioplegia infusion pressure on coronary artery endothelium and cardiac mechanical function.
Topics: Animals; Barotrauma; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Vessels; Endot | 1997 |
Inhibition of endogenous endothelin during cardioplegia improves low coronary reflow following prolonged hypothermic arrest.
Topics: Animals; Bicarbonates; Bosentan; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; End | 1997 |
Experimental study of cardiac lymph dynamics and edema formation in ischemia/reperfusion injury--with reference to the effect of hyaluronidase.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Body Temperature; Body Water; Calcium Chloride; Cardi | 1998 |
Human albumin enriched St. Thomas Hospital cardioplegic solution increases reperfusion injury in isolated perfused rat hearts.
Topics: Albumins; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Fem | 1998 |
Beneficial effect of captopril against ischaemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 1998 |
Experimental study on the scavenging effects of ginsenosides on oxygen free radicals using model of heterotopic heart transplantation in rats.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Disease Models, Animal; Female; Fre | 1998 |
Enflurane and isoflurane, but not halothane, protect against myocardial reperfusion injury after cardioplegic arrest with HTK solution in the isolated rat heart.
Topics: Anesthetics, Inhalation; Animals; Cardioplegic Solutions; Creatine Kinase; Enflurane; Glucose; Halot | 1998 |
No beneficial effects of isocolloidoosmotic synthetic colloid addition to St. Thomas Hospital cardioplegic solution in ischemia-reperfusion injury in isolated perfused rat hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Colloids; Female; Magnesium; Male; | 1999 |
Comparison of clinical outcome between histidine-triptophan-ketoglutalate solution and cold blood cardioplegic solution in mitral valve replacement.
Topics: Blood; Cardioplegic Solutions; Case-Control Studies; Female; Glucose; Heart Valve Prosthesis Implant | 1998 |
Efficacy of contraction uncoupling by 2,3-butanedione monoxime during initial reperfusion versus cardioplegic arrest for protection of isolated hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Diacetyl; Gui | 1999 |
Optimized cardiac graft preservation: a comparative experimental study using P-31 magnetic resonance spectroscopy and biochemical analyses.
Topics: Acid-Base Equilibrium; Adenosine; Adenosine Triphosphate; Allopurinol; Amino Acids; Animals; Bicarbo | 1999 |
Protective effect of histidine on hydroxyl radical generation induced by potassium-depolarization in rat myocardium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Histidine; Hydroxybenzoates; Hydroxyl Radical; Mal | 1999 |
Beneficial effects of sevoflurane and desflurane against myocardial reperfusion injury after cardioplegic arrest.
Topics: Anesthetics, Inhalation; Animals; Creatine Kinase; Desflurane; Diastole; Glucose; Heart Arrest, Indu | 1999 |
The effect of captopril on membrane bound enzymes in ischemia-reperfusion injury.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chloride; Captopril; Cardio | 2000 |
Postischemic cardiac function recovery in the isolated rat heart: effects of adenosine deaminase and nucleoside transport inhibition.
Topics: Adenine; Adenosine Deaminase; Affinity Labels; Animals; Cardioplegic Solutions; Disease Models, Anim | 2000 |
Protective effect of lisinopril against ischemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 2001 |
Myocardial protection: the efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent.
Topics: Adrenergic beta-Antagonists; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Constr | 2001 |
Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Fl | 2002 |
Inhibition of Na(+)/H(+) isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Guanidines; G | 2002 |
Different preservation of myocardial capillary endothelial cells and cardiomyocytes during and after cardioplegic ischemia (25 degrees C) of canine hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endothelium, Vascular; Female | 2002 |
Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration.
Topics: Animals; Arrhythmias, Cardiac; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium; | 1992 |
Detrimental effects of temperature on the efficacy of the University of Wisconsin solution when used for cardioplegia at moderate hypothermia. Comparison with the St. Thomas Hospital solution at 4 degrees C and 20 degrees C.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Endothelium | 1992 |
[The effects of protease inhibitor upon the ischemia-reperfusion injury].
Topics: Animals; Benzamidines; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Guanidines; Magnesium | 1992 |
[The effects of potassium concentration in reperfusion solution upon myocardial protection].
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Dose-Response Rela | 1992 |
The effect of intramyocardial pH on functional recovery in neonatal hearts receiving St. Thomas' Hospital cardioplegic solution during global ischemia.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Hemodynamics; His | 1992 |
Transient hypocalcemic reperfusion does not improve postischemic recovery in the rat heart after preservation with St. Thomas' Hospital cardioplegic solution.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Cr | 1992 |
Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery.
Topics: Acetylcholine; Animals; Bradykinin; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Male; Mic | 1992 |
Comparison of ischemic vulnerability and responsiveness to cardioplegic protection in crystalloid-perfused versus blood-perfused hearts.
Topics: Animals; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; Female; Magnesium; Male; Myo | 1992 |
Successful long-term preservation of the neonatal heart with a modified intracellular solution.
Topics: Adenosine; Allopurinol; Animals; Animals, Newborn; Bicarbonates; Cardioplegic Solutions; Glucose; Gl | 1992 |
Exogenous adenosine accelerates recovery of cardiac function and improves coronary flow after long-term hypothermic storage and transplantation.
Topics: Abdomen; Adenosine; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circul | 1992 |
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.
Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium | 1992 |
Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardiopleg | 1992 |
PEG-SOD and myocardial protection. Studies in the blood- and crystalloid-perfused rabbit and rat hearts.
Topics: Animals; Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; Crystalloid Solutions; Dose- | 1992 |
Protection of immature myocardium by the addition of mannitol to crystalloid cardioplegic solution.
Topics: Adenosine Triphosphate; Adult; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs | 1991 |
Reoxygenation, but neither hypoxia nor intermittent ischemia, increases [125I]endothelin-1 binding to rat cardiac membranes.
Topics: Acidosis; Aerobiosis; Animals; Cell Hypoxia; Coronary Disease; Endothelins; In Vitro Techniques; Iod | 1990 |
Enhanced myocardial protection during global ischemia with 5'-nucleotidase inhibitors.
Topics: 5'-Nucleotidase; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dimethyl Sulfoxide | 1992 |
Perfusate calcium: effect on cardiac stability and response to ischemia and reperfusion.
Topics: Animals; Bicarbonates; Buffers; Calcium; Calcium Chloride; Cardioplegic Solutions; Magnesium; Male; | 1991 |
The effect of high buffer cardioplegia and secondary cardioplegia on cardiac preservation and postischemic functional recovery: a 31P NMR and functional study in Langendorff perfused pig hearts.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Buffers; Calcium; Calcium Chloride; Cardioplegic Solu | 1991 |
St. Thomas' Hospital cardioplegic solution. Beneficial effect of glucose and multidose reinfusions of cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; G | 1991 |
Increased oxygen cost of contractility in stunned myocardium of dog.
Topics: Animals; Blood Pressure; Blood Volume; Coronary Circulation; Dogs; Electrocardiography; Heart Arrest | 1991 |
Patterns of structural deterioration due to ischemia in Purkinje fibres and different layers of the working myocardium.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endocardium; Glucose; Heart A | 1991 |
Species differences in susceptibility to ischemic injury and responsiveness to myocardial protection.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Energy Metabolism; | 1990 |
Prolonged cardiac preservation. Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic solutions in the rat.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegi | 1990 |
[A method of modeling of occlusion-reperfusion induced myocardial infarction and quantitative evaluation of the effectiveness of limitation of its size].
Topics: Animals; Carotid Arteries; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Mat | 1990 |
Cardioplegia-induced damage to ischemic immature myocardium is independent of oxygen availability.
Topics: Animals; Bicarbonates; Buffers; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coronary C | 1990 |
Assessment of ischemic injury and protective interventions: the Langendorff versus the working rat heart preparation.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Disease; Heart; Magnesium; | 1990 |
Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Coronary Vessels; Dogs; Endothelium, Vascular; Female; In Vitro Tech | 1990 |
The concentration of calcium in neonatal cardioplegia.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium; Calcium Chloride; Cardioplegic Solutions; Heart Ar | 1990 |
Free radicals and cardioplegia: organic anti-oxidants as additives to the St Thomas' Hospital cardioplegic solution.
Topics: Animals; Antioxidants; Ascorbic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardio | 1989 |
[Ischemic-reperfusion injury of the heart: comparison of intra- and extracellular types of cardioplegic solutions].
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Glucose; In Vitro Techniques; Magne | 1989 |
Cardioplegia: relation of myocardial protection to infusion volume and duration.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Heart; Heart Arrest | 1989 |
Enhanced myocardial protection with adenosine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; | 1989 |
Age-related changes in the ability of hypothermia and cardioplegia to protect ischemic rabbit myocardium.
Topics: Aging; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Heart; | 1988 |
Optimal myocardial protection during crystalloid cardioplegia. Interrelationship between volume and duration of infusion.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Heart Arrest, Induc | 1988 |