Page last updated: 2024-11-02

potassium chloride and Heart Valve Diseases

potassium chloride has been researched along with Heart Valve Diseases in 14 studies

Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.

Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Research Excerpts

Excerpt	Relevance	Reference
"Seventy-seven patients received large doses of furosemide (> or = 80 mg/24 h) at some time during the postoperative course, and of these 20 responded poorly to furosemide (weight loss 0."	5.08	Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations. ( Broquist, M; Svedjeholm, R; Vánky, F, 1997)
" The effect of two cardioplegic solution was evaluated by postoperative cardiac function (CI, %SF), released enzymes (CPK), histology and dosage of catecholamine."	1.29	[Efficacy of myocardial preservation using HTK solution in continuous 120 min cross-clamping method--a comparative study with GIK method]. ( Bonkohara, Y; Hachida, M; Imamaki, M; Katsumata, T; Koyanagi, H; Nemoto, S; Nonoyama, M; Saitou, S; Satou, M; Toyama, A, 1993)

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (35.71)	18.7374
1990's	4 (28.57)	18.2507
2000's	2 (14.29)	29.6817
2010's	2 (14.29)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Duan, L	1
Hu, GH	1
Wang, E	1
Zhang, CL	1
Huang, LJ	1
Duan, YY	1
Gaudino, M	1
Pragliola, C	1
Anselmi, A	1
Pieroni, M	1
De Paulis, S	1
Leone, A	1
De Caterina, AR	1
Massetti, M	1
Matzelle, SJ	1
Murphy, MJ	1
Weightman, WM	1
Gibbs, NM	1
Edelman, JJ	1
Passage, J	1
Uchikawa, S	1
Aomi, S	1
Kawai, A	1
Yamazaki, K	1
Tomizawa, Y	1
Nishida, H	1
Endo, M	1
Koyanagi, H	2
Savini, C	1
Camurri, N	1
Castelli, A	1
Dell'Amore, A	1
Pacini, D	1
Suarez, SM	1
Grillone, G	1
Di Bartolomeo, R	1
Noyez, L	1
van Son, JA	1
van der Werf, T	1
van Asten, WN	1
Lacquet, LK	1
Hachida, M	1
Bonkohara, Y	1
Nonoyama, M	1
Toyama, A	1
Saitou, S	1
Nemoto, S	1
Satou, M	1
Katsumata, T	1
Imamaki, M	1
Vánky, F	1
Broquist, M	1
Svedjeholm, R	1
Nakayama, Y	1
Aoki, J	1
Irie, H	1
Bando, K	1
Sugawara, E	1
Murakami, T	1
Nawa, S	1
Senoo, Y	1
Teramoto, S	1
Howie, AD	1
Strachan, RW	1
Sakurada, T	1
Kuribayashi, R	1
Sekine, S	1
Aida, H	1
Seki, K	1
Goto, Y	1
Shibata, Y	1
Meguro, A	1
Hayashi, R	1
Saito, S	1
Flameng, W	1
De Meyere, R	1
Daenen, W	1
Sergeant, P	1
Ngalikpima, V	1
Geboers, J	1
Suy, R	1
Stalpaert, G	1
McKnight, CK	1
Elliott, M	1
Pearson, DT	1
Alberti, KG	1
Holden, MP	1
Kühn, P	1
Probst, P	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095]			Phase 2	110 participants (Actual)	Interventional	2012-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality

Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Intervention	participants (Number)
Cardioplegia: Custodiol HTK Solution	0
Cold Blood Cardioplegia	0

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	20
Cold Blood Cardioplegia	24

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	6.0
Cold Blood Cardioplegia	7.8

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	1.9
Cold Blood Cardioplegia	2.6

Cardiac Dysrhythmias

Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery

Intervention	participants (Number)
Cardioplegia: Custodiol HTK Solution	24
Cold Blood Cardioplegia	30

Cardiac Marker - Troponin-I

Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	5.7
Cold Blood Cardioplegia	7.8

Cardiac Marker - Troponin-I

Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	3.0
Cold Blood Cardioplegia	4.8

Cardiac Marker - Troponin-I

Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively

Intervention	ng/mL (Mean)
Cardioplegia: Custodiol HTK Solution	.03
Cold Blood Cardioplegia	.03

Cardiovascular Mortality

Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Intervention	participants (Number)
Cardioplegia: Custodiol HTK Solution	0
Cold Blood Cardioplegia	0

Change in Creatine Phosphokinase-MB Isoenzyme (CK-MB)

Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Intervention	ng/mL (Median)
Cardioplegia: Custodiol HTK Solution	18.8
Cold Blood Cardioplegia	22.2

Change in Troponin I

Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Intervention	ng/mL (Median)
Cardioplegia: Custodiol HTK Solution	9.65
Cold Blood Cardioplegia	10.15

Changes in Left Ventricular (LV) Ejection Fraction (EF) by Transthoracic Echocardiogram (TTE)

LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery

Intervention	% LV volume (Mean)
Cardioplegia: Custodiol HTK Solution	-0.06
Cold Blood Cardioplegia	1.9

Duration of Vasopressor / Inotropic Agent

Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure

Intervention	minutes (Median)
Cardioplegia: Custodiol HTK Solution	340
Cold Blood Cardioplegia	582

Intensive Care Unit (ICU) Length of Stay

Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission

Intervention	days (Median)
Cardioplegia: Custodiol HTK Solution	3
Cold Blood Cardioplegia	3

Myocardial Infarction

Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure

Intervention	participants (Number)
Cardioplegia: Custodiol HTK Solution	0
Cold Blood Cardioplegia	0

Postoperative Inotropic Infusion >20 Minutes

Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure

Intervention	participants (Number)
Cardioplegia: Custodiol HTK Solution	47
Cold Blood Cardioplegia	43

Time on Mechanically Assisted Ventilation

time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure

Intervention	hours (Median)
Cardioplegia: Custodiol HTK Solution	10.5
Cold Blood Cardioplegia	11.4

Trials

4 trials available for potassium chloride and Heart Valve Diseases

Article	Year
Randomized trial of HTK versus warm blood cardioplegia for right ventricular protection in mitral surgery. Scandinavian cardiovascular journal : SCJ, 2013, Volume: 47, Issue:6 Topics: Aged; Cardiac Surgical Procedures; Cardioplegic Solutions; Female; Glucose; Heart Arrest, Induced; H	2013
Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations. The Annals of thoracic surgery, 1997, Volume: 63, Issue:4 Topics: Administration, Oral; Aged; Amiloride; Coronary Artery Bypass; Creatinine; Diuretics; Drug Administr	1997
Nifedipine as an adjunct to St. Thomas' Hospital cardioplegia. A double-blind, placebo-controlled, randomized clinical trial. The Journal of thoracic and cardiovascular surgery, 1986, Volume: 91, Issue:5 Topics: Adult; Aged; Aortic Valve; Bicarbonates; Calcium Chloride; Clinical Trials as Topic; Coronary Artery	1986
Continuous monitoring of blood glucose concentration during open-heart surgery. British journal of anaesthesia, 1985, Volume: 57, Issue:6 Topics: Blood Glucose; Cardiopulmonary Bypass; Female; Gluconates; Heart Valve Diseases; Humans; Isotonic So	1985

Other Studies

10 other studies available for potassium chloride and Heart Valve Diseases

Article	Year
Del Nido versus HTK cardioplegia for myocardial protection during adult complex valve surgery: a retrospective study. BMC cardiovascular disorders, 2021, 12-18, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Cardiac Surgical Procedures; Electrolytes; Female; Glucose; Heart Arrest, I	2021
Minimally invasive mitral valve surgery using single dose antegrade Custodiol cardioplegia. Heart, lung & circulation, 2014, Volume: 23, Issue:9 Topics: Adult; Aged; Blood Transfusion; Cardioplegic Solutions; Cardiotonic Agents; Female; Glucose; Heart A	2014
Left ventricular mass index reduction early after an isolated aortic valve replacement with St. Jude Medical 19A-HP. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 2003, Volume: 51, Issue:8 Topics: Aged; Aortic Valve; Female; Glucose; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Hear	2003
Myocardial protection using HTK solution in minimally invasive mitral valve surgery. The heart surgery forum, 2005, Volume: 8, Issue:1 Topics: Aged; Cardioplegic Solutions; Cardiopulmonary Bypass; Constriction; Creatine Kinase; Creatine Kinase	2005
Haemodynamic evaluation of retrograde versus anterograde delivery of cardioplegic solution in aortic valve replacement. Cardiovascular surgery (London, England), 1993, Volume: 1, Issue:5 Topics: Adult; Aged; Aortic Valve; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Female; Heart Val	1993
[Efficacy of myocardial preservation using HTK solution in continuous 120 min cross-clamping method--a comparative study with GIK method]. [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai, 1993, Volume: 41, Issue:9 Topics: Cardioplegic Solutions; Evaluation Studies as Topic; Glucose; Heart Arrest, Induced; Heart Valve Dis	1993
[The prolonged aortic occlusion in valvular surgery and myocardial protection]. Rinsho kyobu geka = Japanese annals of thoracic surgery, 1988, Volume: 8, Issue:2 Topics: Aorta; Aortic Valve; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Constriction; Female; H	1988
Slow release potassium chloride treatment. British medical journal, 1975, Apr-26, Volume: 2, Issue:5964 Topics: Deglutition Disorders; Delayed-Action Preparations; Female; Heart Valve Diseases; Humans; Middle Age	1975
[Clinical study on the use of retrograde cardioplegia with St. Thomas' Hospital solution]. Kyobu geka. The Japanese journal of thoracic surgery, 1990, Volume: 43, Issue:5 Topics: Adult; Aorta; Aortic Valve; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Artery	1990
[Acid-base equilibrium and blood gas analysis in clinical cardiology]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1970, Volume: 51, Issue:7 Topics: Acetazolamide; Acid-Base Equilibrium; Bicarbonates; Blood Gas Analysis; Body Weight; Diagnosis, Diff	1970