potassium chloride has been researched along with Heart Disease, Ischemic in 67 studies
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 7.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 3.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| " oxygen/ozone mixture were tested on arrhythmias induced by i) ischemia; ii) ischemia/reperfusion; iii) aconitine (15microg/kg/i." | 3.76 | Antiarrhythmic effect of acute oxygen-ozone administration to rats. ( Capodanno, P; Cervone, C; D'Amico, M; Di Filippo, C; di Ronza, C; Luongo, C; Marfella, R; Rossi, C; Rossi, F, 2010) |
| "We previously demonstrated that pinacidil does not affect Na(+)(i) accumulation, cellular energy depletion, or acidosis during myocardial ischemia, but dramatically improves the cationic/energetic status during reperfusion." | 3.72 | Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection. ( Digerness, SB; Guo, LL; Pike, MM; Takayama, E, 2004) |
| "1 mM MgCl2 to iohexol on cardiac electrophysiology and hemodynamics (iohexol+electrolytes = IPE)." | 3.69 | Cardiac effects of coronary arteriography with electrolyte addition to iohexol. A study in dogs with and without heart failure. ( Jacobsen, EA; Kløw, NE; Pedersen, HK; Refsum, H, 1994) |
| " In our study we compared myocardial protection in isolated coronary bypass with a short period of ischemia using low dosage HTK and cold crystalloid cardioplegia." | 2.71 | Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection. ( Akay, T; Arslan, A; Aslamaci, S; Gultekin, B; Ozkan, S; Sezgin, A; Tasdelen, A; Uguz, E, 2005) |
| " Nifedipine at a dosage of 200 micrograms or placebo was added to each 1000 ml of St." | 2.67 | Cardioprotection by nifedipine cardioplegia during coronary artery surgery. ( Haider, W; Laczkovics, A; Moritz, A; Trubel, W; Zwoelfer, W, 1994) |
| "Flecainide was equi-effective at low and high concentrations, with VF incidence reduced from 92% to 17% (p < 0." | 1.31 | Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts. ( Curtis, MJ; Farkas, A, 2002) |
| "Ten bradykinin-pretreated hearts received a 10-minute infusion of 0." | 1.30 | Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways. ( Feng, J; Rosenkranz, ER, 1999) |
| "Effects on ischemia-induced arrhythmias could not be explained by changes in blood pressure or heart rate." | 1.28 | Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration. ( Abraham, S; MacLeod, BA; McGough, J; Saint, KM; Walker, MJ; Yoshida, N, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 41 (61.19) | 18.2507 |
| 2000's | 21 (31.34) | 29.6817 |
| 2010's | 3 (4.48) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Marklund, M | 1 |
| Singh, G | 1 |
| Greer, R | 1 |
| Cudhea, F | 1 |
| Matsushita, K | 1 |
| Micha, R | 1 |
| Brady, T | 1 |
| Zhao, D | 1 |
| Huang, L | 1 |
| Tian, M | 1 |
| Cobb, L | 1 |
| Neal, B | 1 |
| Appel, LJ | 1 |
| Mozaffarian, D | 1 |
| Wu, JHY | 1 |
| Wu, J | 1 |
| Liu, X | 1 |
| Wang, M | 1 |
| Wang, X | 1 |
| Su, S | 1 |
| Li, WC | 1 |
| Gao, H | 1 |
| Gao, J | 1 |
| Wang, ZJ | 1 |
| Jacob, M | 1 |
| Paul, O | 1 |
| Mehringer, L | 1 |
| Chappell, D | 1 |
| Rehm, M | 1 |
| Welsch, U | 1 |
| Kaczmarek, I | 1 |
| Conzen, P | 1 |
| Becker, BF | 1 |
| Di Filippo, C | 1 |
| Cervone, C | 1 |
| Rossi, C | 1 |
| di Ronza, C | 1 |
| Marfella, R | 1 |
| Capodanno, P | 1 |
| Luongo, C | 1 |
| Rossi, F | 1 |
| D'Amico, M | 1 |
| Imura, H | 1 |
| Lin, H | 1 |
| Griffiths, EJ | 1 |
| Suleiman, MS | 2 |
| Ji, B | 1 |
| Feng, Z | 1 |
| Liu, J | 1 |
| Long, C | 1 |
| Ikizler, M | 1 |
| Dernek, S | 1 |
| Sevin, B | 1 |
| Maxey, TS | 1 |
| Kural, T | 1 |
| Yotsumoto, G | 2 |
| Jeschkeit-Schubbert, S | 1 |
| Funcke, C | 1 |
| Kuhn-Régnier, F | 1 |
| Fischer, JH | 1 |
| Czerski, LW | 1 |
| Szweda, PA | 1 |
| Szweda, LI | 1 |
| Wang, J | 1 |
| Zhou, X | 1 |
| Zhao, Y | 1 |
| Tang, H | 1 |
| Hu, Y | 1 |
| Nishikawa, Y | 1 |
| Stepp, DW | 1 |
| Merkus, D | 1 |
| Jones, D | 1 |
| Chilian, WM | 1 |
| Takayama, E | 1 |
| Guo, LL | 1 |
| Digerness, SB | 1 |
| Pike, MM | 1 |
| Dias, RR | 1 |
| Stolf, NA | 1 |
| Dalva, M | 1 |
| Dias, AR | 1 |
| Moreira, LF | 1 |
| Oliveira, SA | 1 |
| Wei, J | 1 |
| Chang, CY | 1 |
| Chuang, YC | 1 |
| Su, SH | 1 |
| Lee, KC | 1 |
| Tung, DY | 1 |
| Lee, SL | 1 |
| Lee, WC | 1 |
| Arslan, A | 1 |
| Sezgin, A | 1 |
| Gultekin, B | 1 |
| Ozkan, S | 1 |
| Akay, T | 1 |
| Uguz, E | 1 |
| Tasdelen, A | 1 |
| Aslamaci, S | 1 |
| Mühlfeld, C | 1 |
| Urru, M | 1 |
| Rümelin, R | 1 |
| Mirzaie, M | 1 |
| Schöndube, F | 1 |
| Richter, J | 5 |
| Dörge, H | 1 |
| Amark, K | 1 |
| Berggren, H | 1 |
| Björk, K | 1 |
| Ekroth, A | 1 |
| Ekroth, R | 1 |
| Nilsson, K | 1 |
| Sunnegårdh, J | 1 |
| Yamamoto, H | 1 |
| Ichikawa, H | 1 |
| Yamamoto, F | 1 |
| Karck, M | 2 |
| Ziemer, G | 1 |
| Zoeller, M | 1 |
| Schulte, S | 1 |
| Juergens, KD | 1 |
| Weisser, H | 1 |
| Haverich, A | 1 |
| Kolocassides, KG | 1 |
| Galiñanes, M | 1 |
| Hearse, DJ | 2 |
| Baker, EJ | 1 |
| Boerboom, LE | 1 |
| Olinger, GN | 1 |
| Baker, JE | 1 |
| Sheridan, FM | 1 |
| Saldanha, C | 1 |
| Dart, AM | 1 |
| Du, XJ | 1 |
| Trubel, W | 1 |
| Zwoelfer, W | 1 |
| Moritz, A | 1 |
| Laczkovics, A | 1 |
| Haider, W | 1 |
| Choong, YS | 2 |
| Cottier, DS | 2 |
| Edgar, SG | 1 |
| Pridjian, AK | 1 |
| Bove, EL | 1 |
| Bolling, SF | 2 |
| Childs, KF | 1 |
| Brosamer, KM | 1 |
| Lupinetti, FM | 1 |
| Pedersen, HK | 1 |
| Jacobsen, EA | 1 |
| Refsum, H | 1 |
| Kløw, NE | 1 |
| Kupriyanov, VV | 1 |
| St Jean, M | 1 |
| Xiang, B | 1 |
| Butler, KW | 1 |
| Deslauriers, R | 1 |
| Chen, W | 1 |
| Steenbergen, C | 1 |
| Levy, LA | 1 |
| Vance, J | 1 |
| London, RE | 1 |
| Murphy, E | 1 |
| Kober, IM | 1 |
| Obermayr, RP | 1 |
| Spieckermann, PG | 1 |
| Lawton, JS | 1 |
| Harrington, GC | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 3 |
| Menasché, P | 1 |
| Mouas, C | 1 |
| Grousset, C | 1 |
| Yamazaki, I | 1 |
| Yano, Y | 1 |
| Kondo, J | 1 |
| Matsumoto, A | 1 |
| Kurata, H | 1 |
| Soma, T | 1 |
| Fukuhiro, Y | 1 |
| Chocron, S | 1 |
| Alwan, K | 1 |
| Toubin, G | 1 |
| Kantelip, B | 1 |
| Clement, F | 1 |
| Kantelip, JP | 1 |
| Etievent, JP | 1 |
| Gavin, JB | 1 |
| Poltronieri, R | 1 |
| Cevese, A | 1 |
| Bregu, R | 1 |
| Motta, A | 1 |
| Zancanaro, C | 1 |
| Bernocchi, P | 1 |
| Moffatt, AC | 1 |
| Dihmis, WC | 1 |
| Caputo, M | 1 |
| Hutter, JA | 1 |
| Angelini, GD | 1 |
| Bryan, AJ | 1 |
| Schmiedl, A | 4 |
| Schnabel, PA | 3 |
| Süzer, O | 2 |
| Diri, E | 1 |
| Konukoğlu, D | 1 |
| Ozüner, Z | 2 |
| Moriyama, Y | 1 |
| Yamaoka, A | 1 |
| Taira, A | 1 |
| Köseoğlu, S | 1 |
| Hachida, M | 1 |
| Lu, H | 1 |
| Ohkado, A | 1 |
| Hoshi, H | 1 |
| Gu, H | 1 |
| Nakanishi, T | 1 |
| Koyanagi, H | 1 |
| Doğan, R | 2 |
| Sarigül, A | 1 |
| Isbir, S | 1 |
| Farsak, B | 2 |
| Tuncer, M | 1 |
| Kilinç, K | 2 |
| Demircin, M | 1 |
| Shanewise, JS | 1 |
| Kosinski, AS | 1 |
| Coto, JA | 1 |
| Jones, EL | 1 |
| Jayawant, AM | 1 |
| Stephenson, ER | 2 |
| Baumgarten, CM | 1 |
| Rohs, TJ | 1 |
| Kilgore, KS | 1 |
| Georges, AJ | 1 |
| Jayawant, M | 1 |
| Askenasy, N | 2 |
| Navon, G | 2 |
| Headrick, JP | 1 |
| McKirdy, JC | 1 |
| Willis, RJ | 1 |
| Gerber, SH | 1 |
| Heyer, C | 1 |
| Krüger, C | 1 |
| Hagl, S | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Ibrahim, MF | 1 |
| Venn, GE | 1 |
| Young, CP | 1 |
| Chambers, DJ | 1 |
| Feng, J | 1 |
| Rosenkranz, ER | 1 |
| Symons, JD | 1 |
| Rendig, SV | 1 |
| Stebbins, CL | 1 |
| Longhurst, JC | 1 |
| Mahmoudian, M | 1 |
| Shafiei, M | 1 |
| Mirkhani, H | 1 |
| Omrani, GR | 1 |
| Selim Isbir, C | 1 |
| Aydin, M | 1 |
| Stoletzki, S | 1 |
| Suzuki, S | 1 |
| Kusano, KF | 1 |
| Goto, Y | 1 |
| Obata, T | 1 |
| Ebihara, A | 1 |
| Yamanaka, Y | 1 |
| Kausch Blecken von Schmeling, H | 1 |
| Marten, K | 1 |
| Farkas, A | 1 |
| Curtis, MJ | 1 |
| Saint, KM | 1 |
| Abraham, S | 1 |
| MacLeod, BA | 1 |
| McGough, J | 1 |
| Yoshida, N | 1 |
| Walker, MJ | 1 |
| Vivi, A | 1 |
| Tassini, M | 1 |
| Schwalb, H | 1 |
| Borman, JB | 1 |
| Uretzky, G | 1 |
| Amrani, M | 1 |
| Shirvani, R | 1 |
| Allen, NJ | 1 |
| Ledingham, S | 1 |
| Yacoub, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
1 review available for potassium chloride and Heart Disease, Ischemic
| Article | Year |
|---|---|
Unexpected drug effects on autonomic function during myocardial ischaemia.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous Sy | 1993 |
6 trials available for potassium chloride and Heart Disease, Ischemic
| Article | Year |
|---|---|
Myocardial protection related to magnesium content of cold blood hyperkalemic cardioplegic solutions in CABG.
Topics: Bicarbonates; Blood; Calcium Chloride; Cardioplegic Solutions; China; Cold Temperature; Coronary Art | 2002 |
Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection.
Topics: Adult; Aged; Cardioplegic Solutions; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Fema | 2005 |
Myocardial metabolism is better preserved after blood cardioplegia in infants.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Aorta; Bicarbonates; Blood; Blood Glucose; Calcium Chloride; Car | 2006 |
Cardioprotection by nifedipine cardioplegia during coronary artery surgery.
Topics: Arrhythmias, Cardiac; Bicarbonates; Calcium Chloride; Cardiac Output; Cardiac Output, Low; Cardiople | 1994 |
Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting.
Topics: Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Artery Bypass; Crystalloid Solution | 1998 |
A clinical comparative study between crystalloid and blood-based St Thomas' hospital cardioplegic solution.
Topics: Adenine Nucleotides; Aged; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Artery B | 1999 |
60 other studies available for potassium chloride and Heart Disease, Ischemic
| Article | Year |
|---|---|
Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study.
Topics: Adult; Aged; Blood Pressure; Cardiovascular Diseases; China; Diet, Sodium-Restricted; Female; Humans | 2020 |
Reduction of Cold Ischemic Injury with the Addition of Compound Glycyrrhizin in HTK Solution in a Mouse Heart Transplantation Model.
Topics: Animals; Anti-Inflammatory Agents; Cold Ischemia; Drug Evaluation, Preclinical; Glucose; Glycyrrhizi | 2020 |
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Gap Junc | 2019 |
Albumin augmentation improves condition of guinea pig hearts after 4 hr of cold ischemia.
Topics: Animals; Cardiac Output; Cell Adhesion; Coronary Vessels; Edema; Endothelium, Vascular; Glucose; Gui | 2009 |
Antiarrhythmic effect of acute oxygen-ozone administration to rats.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Male; Myocardial Ischemia; Oxygen; | 2010 |
Controlled hyperkalemic reperfusion with magnesium rescues ischemic juvenile hearts by reducing calcium loading.
Topics: Age Factors; Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart Rate; Hyperkalemia; | 2011 |
Improved myocardial function with the addition of pinacidil to custadiol.
Topics: Animals; Blood Pressure; Coronary Circulation; Creatine Kinase; Glucose; Heart; Hypothermia, Induced | 2002 |
Total recovery of heart grafts of non-heart-beating donors after 3 hours of hypothermic coronary oxygen persufflation preservation in an orthotopic pig transplantation model.
Topics: Animals; Diacetyl; Glucose; Heart Arrest; Heart Transplantation; Heart-Lung Machine; Hypothermia, In | 2003 |
Dissociation of cytochrome c from the inner mitochondrial membrane during cardiac ischemia.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome c Group; Cytosol; Intra | 2003 |
Myocardial protection of immature rabbits: polarizing versus depolarizing.
Topics: Aging; Animals; Bicarbonates; Body Water; Calcium Chloride; Cardiotonic Agents; Coronary Circulation | 2003 |
In vivo role of heme oxygenase in ischemic coronary vasodilation.
Topics: Animals; Carbon Monoxide; Coronary Circulation; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Endothe | 2004 |
Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection.
Topics: Animals; Calcium; Chlorides; Heart Ventricles; In Vitro Techniques; Membrane Proteins; Myocardial Is | 2004 |
Inclusion of lidocaine in cardioplegic solutions provides additional myocardial protection.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Creatine Kinas | 2004 |
Successful heart transplantation after 13 hours of donor heart ischemia with the use of HTK solution: a case report.
Topics: Adolescent; Glucose; Heart; Heart Transplantation; Humans; Male; Mannitol; Myocardial Ischemia; Pota | 2005 |
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
Topics: Animals; Decanoic Acids; Glucose; Hydroxy Acids; Mannitol; Mitochondria; Myocardial Ischemia; Myocyt | 2006 |
[Diltiazem abolishes the effect of ryanodine in St. Thomas' Hospital cardioplegic solution on the post-ischemic functional recovery].
Topics: Animals; Bicarbonates; Calcium; Calcium Channels; Calcium Chloride; Diltiazem; Heart Arrest, Induced | 1995 |
Protection of the chronic hypoxic immature rat heart during global ischemia.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Blood Gas Analysis; Calcium Chloride; Cardioplegic So | 1995 |
Ischemic preconditioning, cardioplegia or both?
Topics: Animals; Bicarbonates; Calcium Chloride; Coronary Circulation; Heart Arrest, Induced; Magnesium; Mal | 1994 |
Tolerance of the developing heart to ischemia: impact of hypoxemia from birth.
Topics: Age Factors; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Crea | 1995 |
The vasoactive effect of serotonin on canine coronary arteries after ischemia and reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vasospasm; Cor | 1994 |
Cardioplegia and vascular injury. Dissociation of the effects of ischemia from those of the cardioplegic solution.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Endothelium, Vascular; Heart Arrest | 1994 |
Protective effects of oxygenated St. Thomas' Hospital cardioplegic solution during ischaemic cardiac arrest: improved function, metabolism and ultrastructure.
Topics: Analysis of Variance; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Drug Evaluati | 1993 |
Developmental differences in myocardial protection in response to 5'-nucleotidase inhibition.
Topics: 5'-Nucleotidase; Aging; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardiac Output; C | 1994 |
Cardiac effects of coronary arteriography with electrolyte addition to iohexol. A study in dogs with and without heart failure.
Topics: Animals; Blood Pressure; Calcium Chloride; Cardiac Output; Cardiac Output, Low; Coronary Angiography | 1994 |
Contractile dysfunction caused by normothermic ischaemia and KCL arrest in the isolated pig heart: a 31P NMR study.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Energy Metabolism; Hydrogen-Ion Concentratio | 1995 |
Measurement of free Ca2+ in sarcoplasmic reticulum in perfused rabbit heart loaded with 1,2-bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N',N'-tetraacetic acid by 19F NMR.
Topics: Animals; Calcium; Chelating Agents; Cytosol; Diastole; Egtazic Acid; Fluorescent Dyes; Fluorine; Hea | 1996 |
How beneficial is the reduction of edema formation by polyethylene glycol during cardioplegic arrest?
Topics: Animals; Blood Pressure; Cardioplegic Solutions; Coronary Circulation; Edema; Glucose; Heart; Heart | 1996 |
Myocardial protection with pinacidil cardioplegia in the blood-perfused heart.
Topics: Animals; Blood; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Dose-R | 1996 |
Is potassium channel opening an effective form of preconditioning before cardioplegia?
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circ | 1996 |
[Comparison between intermittent retrograde cold blood cardioplegia and retrograde crystalloid cardioplegia].
Topics: Aged; Bicarbonates; Calcium Chloride; Cardiopulmonary Bypass; Creatine Kinase; Female; Heart Arrest, | 1996 |
[The experimental study of myocardial protection for warm myocardial ischemia in an isolated rat heart: the effect of a calcium antagonist].
Topics: Animals; Bicarbonates; Calcium Channel Blockers; Calcium Chloride; Cardioplegic Solutions; Diltiazem | 1996 |
Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Creatine Kinase; Heart | 1996 |
Cardioplegic protection of hearts with pre-arrest ischaemic injury: effect of glucose, aspartate, and lactobionate.
Topics: Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; Disacchar | 1995 |
Biochemical and morphological changes in isolated rabbit hearts after prolonged hypothermic ischaemia: comparison of two cardioplegic solutions.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Ki | 1995 |
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
Topics: Adenosine Triphosphate; Aged; Bicarbonates; Biomarkers; Blood; Calcium Chloride; Cardioplegic Soluti | 1997 |
Cellular edema and alterations in metabolite content in the ischemic and reperfused canine heart following different forms of cardiac arrest.
Topics: Animals; Aorta; Bicarbonates; Calcium Chloride; Cardiomyopathies; Cardioplegic Solutions; Constricti | 1996 |
The role of isocolloidoosmotic synthetic colloid addition to St. Thomas Hospital cardioplegic solution for cardioprotection in isolated perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Colloids; C | 1997 |
Experimental study of cardiac lymph dynamics and edema formation in ischemia/reperfusion injury--with reference to the effect of hyaluronidase.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Body Temperature; Body Water; Calcium Chloride; Cardi | 1998 |
Human albumin enriched St. Thomas Hospital cardioplegic solution increases reperfusion injury in isolated perfused rat hearts.
Topics: Albumins; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Fem | 1998 |
Effectiveness of ischemic preconditioning on long-term myocardial preservation.
Topics: Animals; Calcium; Cardioplegic Solutions; Coronary Circulation; Creatine Kinase; Glucose; Heart; In | 1998 |
Beneficial effect of captopril against ischaemia-reperfusion injury in isolated guinea pig hearts.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chlor | 1998 |
Prevention of cell swelling with low chloride St. Thomas' Hospital solution improves postischemic myocardial recovery.
Topics: Animals; Atrioventricular Node; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; C | 1998 |
Postischemic function and protein kinase C signal transduction.
Topics: Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Bicarbonates; Calcium Chloride; Cardioplegi | 1998 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Intracellular volumes and membrane permeability in rat hearts during prolonged hypothermic preservation with St Thomas and University of Wisconsin solutions.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cell Membrane Permeability; Cryopre | 1998 |
Functional and metabolic effects of extracellular magnesium in normoxic and ischemic myocardium.
Topics: Adenosine Triphosphate; Animals; Calcium; Cytosol; Depression, Chemical; Extracellular Space; Magnes | 1998 |
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fev | 1999 |
Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways.
Topics: Animals; Bicarbonates; Bradykinin; Calcium Chloride; Coronary Circulation; Diastole; Heart Arrest, I | 1999 |
Microvascular and myocardial contractile responses to ischemia: influence of exercise training.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Carbon D | 2000 |
Effects of different vasodilators on human internal mammary artery in vitro.
Topics: Ethanolamines; Female; Humans; In Vitro Techniques; Isoproterenol; Isosorbide Dinitrate; Male; Mamma | 1999 |
The protective effect of lisinopril on membrane-bound enzymes in myocardial preservation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bicarbonates; Calcium Chloride; Calcium-Transport | 2000 |
Intercalated clear cells or pale cells in the sinus node of canine hearts? An ultrastructural study.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Female; Glucose; Heart; Heart | 2000 |
Effects of repetitive brief ischemia on contractile efficiency and oxygen cost of contractility in dog heart.
Topics: Animals; Calcium; Cardiac Volume; Coronary Circulation; Dogs; Energy Metabolism; In Vitro Techniques | 2000 |
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart.
Topics: Animals; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Heart; Hydroxyl Radical; Hydr | 2001 |
Swelling of capillary endothelial cells and cardiomyocytes in the ischaemic myocardium of artificially arrested canine hearts.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Capillaries; Cardioplegic Solutions | 2001 |
Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Fl | 2002 |
Different preservation of myocardial capillary endothelial cells and cardiomyocytes during and after cardioplegic ischemia (25 degrees C) of canine hearts.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endothelium, Vascular; Female | 2002 |
Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration.
Topics: Animals; Arrhythmias, Cardiac; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium; | 1992 |
The effectiveness of University of Wisconsin solution on prolonged myocardial protection as assessed by phosphorus 31-nuclear magnetic resonance spectroscopy and functional recovery.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bicarbonates; Body Water; Calcium Chloride; | 1992 |
Enhancement of low coronary reflow improves postischemic myocardial function.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardiac Output; Cardioplegic Solutions; Coronary Circulatio | 1992 |