potassium chloride has been researched along with Epilepsy in 30 studies
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
potassium chloride : A metal chloride salt with a K(+) counterion.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 70-year-old patient treated with oxcarbazepine experienced severe hyponatremia." | 7.73 | [A case of severe hyponatremia in a patient suffering from epilepsy and using oxcarbazepine]. ( Gumbrevicius, G; Sveikata, A, 2006) |
| "Kainate-induced epilepsy has been shown to be associated with increased levels of neuropeptide Y (NPY) in the rat hippocampus." | 3.73 | Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats. ( Cavadas, C; Cristóvão, A; Ferreira, R; Grouzmann, E; Lourenço, J; Malva, JO; Oliveira, CR; Pinheiro, PS; Silva, AP; Xapelli, S, 2005) |
| "A 70-year-old patient treated with oxcarbazepine experienced severe hyponatremia." | 3.73 | [A case of severe hyponatremia in a patient suffering from epilepsy and using oxcarbazepine]. ( Gumbrevicius, G; Sveikata, A, 2006) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| " The toxic effect of gamma-vinyl-GABA was mimicked by a 24-h treatment with GABA (100 microM) and the GABA(A) receptor agonist, muscimol (10 microM), but not the GABA(B) receptor agonist, baclofen (10 microM)." | 1.31 | GABA(A)-mediated toxicity of hippocampal neurons in vitro. ( Lukasiuk, K; Pitkänen, A, 2000) |
| "These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary bursts." | 1.30 | Seizure-like events in disinhibited ventral slices of adult rat hippocampus. ( Borck, C; Jefferys, JG, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaggi, AS | 1 |
| Kaur, A | 1 |
| Bali, A | 1 |
| Singh, N | 1 |
| Stafstrom, CE | 1 |
| Ockuly, JC | 1 |
| Murphree, L | 1 |
| Valley, MT | 1 |
| Roopra, A | 1 |
| Sutula, TP | 1 |
| Tinnes, S | 1 |
| Schäfer, MK | 1 |
| Flubacher, A | 1 |
| Münzner, G | 1 |
| Frotscher, M | 1 |
| Haas, CA | 1 |
| Eun, B | 1 |
| Kim, HJ | 1 |
| Kim, SY | 1 |
| Kim, TW | 1 |
| Hong, ST | 1 |
| Choi, KM | 1 |
| Shim, JK | 1 |
| Moon, Y | 1 |
| Son, GH | 1 |
| Kim, K | 1 |
| Kim, H | 1 |
| Sun, W | 1 |
| Silva, AP | 1 |
| Xapelli, S | 1 |
| Pinheiro, PS | 1 |
| Ferreira, R | 1 |
| Lourenço, J | 1 |
| Cristóvão, A | 1 |
| Grouzmann, E | 1 |
| Cavadas, C | 1 |
| Oliveira, CR | 1 |
| Malva, JO | 1 |
| Oby, E | 1 |
| Caccia, S | 1 |
| Vezzani, A | 1 |
| Moeddel, G | 1 |
| Hallene, K | 1 |
| Guiso, G | 1 |
| Said, T | 1 |
| Bingaman, W | 1 |
| Marchi, N | 1 |
| Baumgartner, C | 1 |
| Pirker, S | 1 |
| Czech, T | 1 |
| Lo Russo, G | 1 |
| Janigro, D | 1 |
| Gumbrevicius, G | 1 |
| Sveikata, A | 1 |
| Chai, ZF | 1 |
| Bai, ZT | 1 |
| Zhang, XY | 1 |
| Liu, T | 1 |
| Pang, XY | 1 |
| Ji, YH | 1 |
| Glasscock, E | 1 |
| Qian, J | 1 |
| Yoo, JW | 1 |
| Noebels, JL | 1 |
| BROWN, MR | 1 |
| Haglund, MM | 1 |
| Schwartzkroin, PA | 1 |
| Avoli, M | 1 |
| Gloor, P | 1 |
| Lin, FH | 1 |
| Wang, Y | 2 |
| Lin, S | 1 |
| Cao, Z | 1 |
| Hosford, DA | 2 |
| Rutecki, PA | 1 |
| Herdegen, T | 1 |
| Sandkühler, J | 1 |
| Gass, P | 1 |
| Kiessling, M | 1 |
| Bravo, R | 1 |
| Zimmermann, M | 1 |
| Yan, QS | 1 |
| Jobe, PC | 1 |
| Dailey, JW | 1 |
| Guedes, RC | 1 |
| Cavalheiro, EA | 1 |
| Ameri, A | 2 |
| Kunz, WS | 1 |
| Goussakov, IV | 1 |
| Beck, H | 1 |
| Elger, CE | 1 |
| Lin, F | 1 |
| Barun, S | 1 |
| Lutz, CM | 1 |
| Borck, C | 1 |
| Jefferys, JG | 1 |
| Lukasiuk, K | 1 |
| Pitkänen, A | 1 |
| Gorji, A | 1 |
| Scheller, D | 1 |
| Straub, H | 1 |
| Tegtmeier, F | 1 |
| Köhling, R | 1 |
| Höhling, JM | 1 |
| Tuxhorn, I | 1 |
| Ebner, A | 1 |
| Wolf, P | 1 |
| Werner Panneck, H | 1 |
| Oppel, F | 1 |
| Speckmann, EJ | 1 |
| Amano, H | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Ishihara, K | 1 |
| Serikawa, T | 1 |
| Sasa, M | 1 |
| Morgan, SL | 1 |
| Teyler, TJ | 1 |
| Sramka, M | 1 |
| Brozek, G | 1 |
| Fritz, G | 1 |
| Bures, J | 1 |
| Nádvorník, P | 1 |
| White, HS | 1 |
| Skeen, GA | 1 |
| Edwards, JA | 1 |
| Grimm, RJ | 1 |
| Frazee, JG | 1 |
| Ozbay, S | 1 |
| Buehler, B | 1 |
| Kohut, RI | 1 |
| King, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for potassium chloride and Epilepsy
| Article | Year |
|---|---|
Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Ion Transport; Potassium Chloride; Sodium; Symporters | 2015 |
Pharmacological regulation of astrocytic calcium channels: implications for the treatment of seizure disorders.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Channels; Cells, Cultured; Drug Design; Epile | 1992 |
28 other studies available for potassium chloride and Epilepsy
| Article | Year |
|---|---|
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
Topics: Animals; Anticonvulsants; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2009 |
Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Endoplasmic Reticulum; Epilepsy; Excitato | 2011 |
Induction of Per1 expression following an experimentally induced epilepsy in the mouse hippocampus.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists | 2011 |
Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Epilepsy; Glutamic Acid; Hippocampus; Kainic Aci | 2005 |
In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Brain; Child; Child, Preschool; Chromatography, H | 2006 |
[A case of severe hyponatremia in a patient suffering from epilepsy and using oxcarbazepine].
Topics: Aged; Anticonvulsants; Antiemetics; Carbamazepine; Dopamine Antagonists; Epilepsy; Female; Follow-Up | 2006 |
Rat epileptic seizures evoked by BmK alphaIV and its possible mechanisms involved in sodium channels.
Topics: Animals; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electro | 2007 |
Masking epilepsy by combining two epilepsy genes.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Typ | 2007 |
Paroxysmal cerebral dysrhythmia following large doses of potassium chloride.
Topics: Arrhythmias, Cardiac; Epilepsy; Potassium; Potassium Chloride | 1948 |
Seizure-like spreading depression in immature rabbit hippocampus in vitro.
Topics: Animals; Bicuculline; Disease Models, Animal; Electrophysiology; Epilepsy; Hippocampus; In Vitro Tec | 1984 |
The effects of transient functional depression of the thalamus on spindles and on bilateral synchronous epileptic discharges of feline generalized penicillin epilepsy.
Topics: Animals; Cats; Cortical Spreading Depression; Electroencephalography; Epilepsy; Female; Male; Microi | 1981 |
GABAB receptor-mediated effects in synaptosomes of lethargic (lh/lh) mice.
Topics: Animals; Calcium; Cerebral Cortex; Colforsin; Cyclic AMP; Epilepsy; Epilepsy, Absence; gamma-Aminobu | 1995 |
Noradrenergic modulation of epileptiform activity in the hippocampus.
Topics: Adrenergic Agents; Adrenergic Antagonists; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Nore | 1995 |
JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures.
Topics: Activating Transcription Factor 1; Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depress | 1993 |
Thalamic deficiency in norepinephrine release detected via intracerebral microdialysis: a synaptic determinant of seizure predisposition in the genetically epilepsy-prone rat.
Topics: Analysis of Variance; Animals; Desipramine; Dialysis; Epilepsy; Female; Norepinephrine; Potassium Ch | 1993 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
Inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices by the Aconitum alkaloid mesaconitine.
Topics: Aconitine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Bicu | 1998 |
Structure-dependent inhibitory action of the Aconitum alkaloids 14-benzoyltalitasamine and talitasamine in rat hippocampal slices.
Topics: Aconitine; Alkaloids; Animals; Depression, Chemical; Electric Stimulation; Electrophysiology; Epilep | 1998 |
Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats.
Topics: Animals; Benzimidazoles; Calcium; Chelating Agents; Coloring Agents; Disease Models, Animal; Egtazic | 1999 |
Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cerebral Cortex; Epilepsy; Homozygote; In | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials | 1999 |
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
Topics: Animals; Anticonvulsants; Bicuculline; Cell Survival; Cells, Cultured; Epilepsy; Female; Fetus; GABA | 2000 |
Spreading depression in human neocortical slices.
Topics: Adolescent; Adult; Amiloride; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Child; | 2001 |
Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats.
Topics: Animals; Calcium; Calcium Channels; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationshi | 2001 |
Epileptic-like activity induces multiple forms of plasticity in hippocampal area CA1.
Topics: Animals; Calcium Channels, L-Type; Electrophysiology; Epilepsy; Hippocampus; Ion Channels; Long-Term | 2001 |
[Ablation of nerve structures with the aid of spreading depression in neurosurgical operations].
Topics: Caudate Nucleus; Child; Cortical Spreading Depression; Epilepsy; Hippocampus; Humans; Potassium Chlo | 1979 |
After-discharge bursts in cobalt and penicillin foci in primate cortex.
Topics: Action Potentials; Alpha Rhythm; Animals; Cerebral Cortex; Cobalt; Cortical Spreading Depression; Di | 1973 |
Repeatable alteration of vestibular responses by cortical depression.
Topics: Animals; Cats; Cortical Spreading Depression; Electroencephalography; Electrooculography; Epilepsy; | 1969 |