porphobilinogen has been researched along with Disease Models, Animal in 12 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Accurate determinations of 5-aminolevulinic acid (ALA) and porphobilinogen (PBG) in physiologic fluids are required for the diagnosis and therapeutic monitoring of acute porphyrias." | 3.77 | A LC-MS/MS method for the specific, sensitive, and simultaneous quantification of 5-aminolevulinic acid and porphobilinogen. ( Balwani, M; Bishop, D; Desnick, RJ; Yasuda, M; Yu, C; Zhang, J, 2011) |
| "We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage." | 3.71 | The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. ( Aldonatti, C; Galigniana, M; Mazzetti, MB; Ríos de Molina, MC; San Martín de Viale, LC; Tomio, JM, 2002) |
| "Urinary excretion of porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) and total porphyrins was measured during intoxication of rats with 2,4-dithiobiuret (DTB), a chemical which produces delayed-onset neuromuscular weakness, in an attempt to ascertain whether or not DTB poisoning in the rat would serve as an animal model of the neurologic symptoms of acute intermittent porphyria." | 3.67 | Excretion of porphyrins and porphyrin precursors during neuromuscular paralysis produced by dithiobiuret. ( Atchison, WD; Peterson, RE, 1984) |
| "Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria." | 3.67 | Influence of chloroquine on the porphyrin metabolism. ( Bolsen, K; Goerz, G; Merk, H, 1985) |
| "It was investigated whether an increased demand for glycine, as postulated to occur in patients who have suffered from episodic psychoses accompanied by multiple perceptual distortions, could evoke psychotic reactions." | 3.66 | Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983) |
| " Finally, a theoretical hemin effect was implemented to illustrate the applicability of the model to dosage optimization in drug therapies." | 1.51 | Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. ( Fontanellas, A; Jericó, D; Parra-Guillén, ZP; Sampedro, A; Serrano-Mendioroz, I; Trocóniz, IF; Vera-Yunca, D, 2019) |
| "1." | 1.28 | Physiological basis for an animal model of the renal Fanconi syndrome: use of succinylacetone in the rat. ( Boynton, SB; Chu, J; Roth, KS; Spencer, RF; Wyss, PA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vera-Yunca, D | 1 |
| Serrano-Mendioroz, I | 1 |
| Sampedro, A | 2 |
| Jericó, D | 1 |
| Trocóniz, IF | 1 |
| Fontanellas, A | 2 |
| Parra-Guillén, ZP | 1 |
| Yin, Z | 1 |
| Wahlin, S | 1 |
| Ellis, EC | 1 |
| Harper, P | 1 |
| Ericzon, BG | 1 |
| Nowak, G | 1 |
| Unzu, C | 1 |
| Mauleón, I | 1 |
| Vanrell, L | 1 |
| Dubrot, J | 1 |
| de Salamanca, RE | 1 |
| González-Aseguinolaza, G | 1 |
| Melero, I | 1 |
| Prieto, J | 1 |
| Zhang, J | 1 |
| Yasuda, M | 1 |
| Desnick, RJ | 1 |
| Balwani, M | 1 |
| Bishop, D | 1 |
| Yu, C | 1 |
| Fang, L | 1 |
| Green, SR | 1 |
| Baek, JS | 1 |
| Lee, SH | 1 |
| Ellett, F | 1 |
| Deer, E | 1 |
| Lieschke, GJ | 1 |
| Witztum, JL | 1 |
| Tsimikas, S | 1 |
| Miller, YI | 1 |
| Ríos de Molina, MC | 1 |
| Mazzetti, MB | 1 |
| Galigniana, M | 1 |
| Aldonatti, C | 1 |
| Tomio, JM | 1 |
| San Martín de Viale, LC | 1 |
| Schouten, MJ | 1 |
| Bruinvels, J | 1 |
| Pepplinkhuizen, L | 1 |
| Wilson, JH | 1 |
| Atchison, WD | 1 |
| Peterson, RE | 1 |
| Wyss, PA | 1 |
| Boynton, SB | 1 |
| Chu, J | 1 |
| Spencer, RF | 1 |
| Roth, KS | 1 |
| Goerz, G | 1 |
| Bolsen, K | 1 |
| Merk, H | 1 |
| Simon, N | 1 |
| Siklósi, C | 1 |
| Levin, EY | 1 |
| Flyger, V | 1 |
12 other studies available for porphobilinogen and Disease Models, Animal
| Article | Year |
|---|---|
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Topics: Aminolevulinic Acid; Animals; Computer Simulation; Disease Models, Animal; Male; Mice; Mice, Inbred | 2019 |
Hepatocyte transplantation ameliorates the metabolic abnormality in a mouse model of acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cu | 2014 |
Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Bone Marrow Transplantation; Disease Models, Animal; Erythrocytes; Fem | 2010 |
A LC-MS/MS method for the specific, sensitive, and simultaneous quantification of 5-aminolevulinic acid and porphobilinogen.
Topics: Adolescent; Adult; Aminolevulinic Acid; Animals; Child; Child, Preschool; Chromatography, Liquid; Di | 2011 |
In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish.
Topics: Animals; Animals, Genetically Modified; Antibodies, Monoclonal; Anticholesteremic Agents; Blood Vess | 2011 |
The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage.
Topics: Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Ethanol; Female; Ferrochelatase; He | 2002 |
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; H | 1983 |
Excretion of porphyrins and porphyrin precursors during neuromuscular paralysis produced by dithiobiuret.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Levulinic Acids; Male; Muscle Hypotonia; Neuro | 1984 |
Physiological basis for an animal model of the renal Fanconi syndrome: use of succinylacetone in the rat.
Topics: Amino Acids; Animals; Creatinine; Disease Models, Animal; Fanconi Syndrome; Glucose; Heptanoates; Ki | 1992 |
Influence of chloroquine on the porphyrin metabolism.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Aminopyrine N-Demethylase; Animals; Aryl Hydroca | 1985 |
[Experimental porphyria model with hexachlorocyclohexane].
Topics: Aminolevulinic Acid; Animals; Chlorobenzenes; Diet; Disease Models, Animal; Feces; Female; Hexachlor | 1974 |
Erythropoietic porphyria of the fox squirrel Sciurus niger.
Topics: Animals; Bone Marrow; Bone Marrow Diseases; Disease Models, Animal; Erythrocytes; Erythropoiesis; He | 1973 |