ponalrestat has been researched along with Pregnancy in 3 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zopolrestat was found to be more potent than 207, both in vitro and in vivo." | 1.28 | Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. ( Aldinger, CE; Beyer, TA; Dee, MF; Larson, ER; Mylari, BL; Siegel, TW; Singleton, DH; Zembrowski, WJ, 1991) |
| "Dithiothreitol treatment of ALR2 did not alter its properties toward other substrates or affect its inhibition by aldose reductase inhibitors such as sorbinil (2,4-dihydro-6-fluorospiro-[4H-1-benzopyran-4,4'-imidazolidine]-2' ,5'- dione), tolrestat (N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N- methylglycine), or statil (3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineac etic acid)." | 1.28 | Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms. ( Deck, LM; Hunsaker, LA; Robinson, B; Stangebye, LA; Vander Jagt, DL, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mylari, BL | 1 |
| Larson, ER | 1 |
| Beyer, TA | 1 |
| Zembrowski, WJ | 1 |
| Aldinger, CE | 1 |
| Dee, MF | 1 |
| Siegel, TW | 1 |
| Singleton, DH | 1 |
| Vander Jagt, DL | 1 |
| Hunsaker, LA | 1 |
| Robinson, B | 1 |
| Stangebye, LA | 1 |
| Deck, LM | 1 |
| Eriksson, UJ | 1 |
| Brolin, SE | 1 |
| Naeser, P | 1 |
3 other studies available for ponalrestat and Pregnancy
| Article | Year |
|---|---|
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Female; Humans; Indicators and Reage | 1991 |
Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Chromatography, High Pressure Liquid; Dithiothreitol; Ele | 1990 |
Influence of sorbitol accumulation on growth and development of embryos cultured in elevated levels of glucose and fructose.
Topics: Abnormalities, Drug-Induced; Aldehyde Reductase; Animals; Embryo, Mammalian; Female; Fructose; Gluco | 1989 |