ponalrestat has been researched along with Galactosemias in 4 studies
Galactosemias: A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental galactosemia, induced by feeding rats a galactose enriched diet, reproduces many of the neural and ocular complications of diabetes and induces protein glycation and polyol accumulation." | 1.28 | Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia. ( Daniels, BS; Hostetter, TH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cameron, NE | 1 |
| Cotter, MA | 1 |
| Daniels, BS | 1 |
| Hostetter, TH | 1 |
| Terubayashi, H | 2 |
| Akagi, Y | 2 |
| Ikebe, H | 1 |
| Takahashi, Y | 1 |
| Tsuji, T | 1 |
4 other studies available for ponalrestat and Galactosemias
| Article | Year |
|---|---|
Contraction and relaxation of aortas from galactosaemic rats and the effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Aorta; Diabetes Mellitus; Galactosemias; Male; Phthalazines; Rats; Rats | 1993 |
Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia.
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Kidney Glomerulus; Male; Permeability; Phthala | 1991 |
The effect of aldose reductase inhibitor, statil, on hyperpermeability of iridial vessels in experimental galactosemic rats.
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Fluorescein Angiography; Galactosemias; Iris; M | 1989 |
[Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract].
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Oxazines; Phthalazines; Pyrroles; Rats; Rats, | 1989 |