ponalrestat has been researched along with Diabetic Retinopathy in 6 studies
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ponalrestat administration at a dosage of 600 mg daily for 12 months has no significant effect on the course of minimal retinopathy in diabetic patients." | 2.67 | The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy. ( Barendsen, BC; Hooymans, JM; Tromp, A; van Doormaal, JJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lightman, S | 1 |
| Kamijo, M | 1 |
| Cherian, PV | 1 |
| Sima, AA | 2 |
| Tromp, A | 1 |
| Hooymans, JM | 1 |
| Barendsen, BC | 1 |
| van Doormaal, JJ | 1 |
| Chakrabarti, S | 1 |
| Hotta, N | 1 |
| Sakamoto, N | 1 |
| Kador, PF | 1 |
| Kinoshita, JH | 1 |
| Sharpless, NE | 1 |
3 reviews available for ponalrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
Does aldose reductase have a role in the development of the ocular complications of diabetes?
Topics: Aldehyde Reductase; Animals; Cataract; Clinical Trials as Topic; Corneal Diseases; Diabetes Mellitus | 1993 |
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies | 1987 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
1 trial available for ponalrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy.
Topics: Adolescent; Adult; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabeti | 1991 |
2 other studies available for ponalrestat and Diabetic Retinopathy
| Article | Year |
|---|---|
The preventive effect of aldose reductase inhibition on diabetic optic neuropathy in the BB/W-rat.
Topics: Aldehyde Reductase; Animals; Atrophy; Axons; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Diabe | 1993 |
Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Capillaries; Chronic Disease; Diabeti | 1989 |