ponalrestat has been researched along with Diabetes Mellitus, Type 1 in 15 studies
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteinuria was attributed to an increase in albumin and an array of proteins having molecular weights between 30,000 and 100,000 daltons." | 5.28 | Comparison of sorbinil and ponalrestat (Statil) diminution of proteinuria in the BB rat. ( Beyer-Mears, A; Cruz, E; Murray, FT; Rountree, J; Sciadini, M, 1992) |
| " Ponalrestat administration at a dosage of 600 mg daily for 12 months has no significant effect on the course of minimal retinopathy in diabetic patients." | 2.67 | The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy. ( Barendsen, BC; Hooymans, JM; Tromp, A; van Doormaal, JJ, 1991) |
| "Proteinuria was attributed to an increase in albumin and an array of proteins having molecular weights between 30,000 and 100,000 daltons." | 1.28 | Comparison of sorbinil and ponalrestat (Statil) diminution of proteinuria in the BB rat. ( Beyer-Mears, A; Cruz, E; Murray, FT; Rountree, J; Sciadini, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 13 (86.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamijo, M | 1 |
| Cherian, PV | 1 |
| Sima, AA | 2 |
| Boland, OM | 1 |
| Blackwell, CC | 1 |
| Clarke, BF | 1 |
| Ewing, DJ | 1 |
| Tebbs, SE | 2 |
| Lumbwe, CM | 1 |
| Tesfaye, S | 1 |
| Gonzalez, AM | 2 |
| Wilson, RM | 2 |
| Beyer-Mears, A | 1 |
| Murray, FT | 1 |
| Cruz, E | 1 |
| Rountree, J | 1 |
| Sciadini, M | 1 |
| Rosenbloom, AL | 1 |
| Buithieu, M | 1 |
| Jelliffe, KA | 1 |
| Aitchison, RD | 1 |
| Truglia, JA | 1 |
| Ziegler, D | 1 |
| Mayer, P | 1 |
| Rathmann, W | 1 |
| Gries, FA | 1 |
| Tromp, A | 1 |
| Hooymans, JM | 1 |
| Barendsen, BC | 1 |
| van Doormaal, JJ | 1 |
| Passa, P | 1 |
| Leblanc, H | 1 |
| Billault, B | 1 |
| Ramirez, LC | 1 |
| Arauz, C | 1 |
| Pruneda, L | 1 |
| Hammon, K | 1 |
| Rosenstock, J | 1 |
| Raskin, P | 1 |
| Pedersen, MM | 1 |
| Christiansen, JS | 1 |
| Mogensen, CE | 1 |
| Price, DE | 2 |
| Alani, SM | 1 |
| Wales, JK | 2 |
| Ghahary, A | 1 |
| Chakrabarti, S | 1 |
| Murphy, LJ | 1 |
| Airey, CM | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 1 |
| Rillaerts, EG | 1 |
| Vertommen, JJ | 1 |
| De Leeuw, IH | 1 |
1 review available for ponalrestat and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
[Prevention of terminal kidney failure in insulin-dependent diabetics. Current status and prospects].
Topics: Acute Kidney Injury; Aldehyde Reductase; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive A | 1991 |
8 trials available for ponalrestat and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Effects of ponalrestat, an aldose reductase inhibitor, on neutrophil killing of Escherichia coli and autonomic function in patients with diabetes mellitus.
Topics: Aldehyde Reductase; Analysis of Variance; Autonomic Nervous System; Blood Pressure; Diabetes Mellitu | 1993 |
Effect of an aldose reductase inhibiting agent on limited joint mobility in IDDM.
Topics: Adult; Aldehyde Reductase; Blood Pressure; Diabetes Mellitus, Type 1; Double-Blind Method; Female; G | 1992 |
One-year treatment with the aldose reductase inhibitor, ponalrestat, in diabetic neuropathy.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dou | 1991 |
The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy.
Topics: Adolescent; Adult; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabeti | 1991 |
The effect of aldose reductase inhibition with ponalrestat on the width of the capillary basement membrane in diabetes mellitus.
Topics: Aldehyde Reductase; Analysis of Variance; Basement Membrane; Capillaries; Diabetes Mellitus, Type 1; | 1991 |
Reduction of glomerular hyperfiltration in normoalbuminuric IDDM patients by 6 mo of aldose reductase inhibition.
Topics: Adult; Albuminuria; Aldehyde Reductase; Blood Pressure; Diabetes Mellitus, Type 1; Glomerular Filtra | 1991 |
Effect of aldose reductase inhibition on resistance to ischemic conduction block in diabetic subjects.
Topics: Aldehyde Reductase; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double- | 1991 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
6 other studies available for ponalrestat and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The preventive effect of aldose reductase inhibition on diabetic optic neuropathy in the BB/W-rat.
Topics: Aldehyde Reductase; Animals; Atrophy; Axons; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Diabe | 1993 |
The influence of aldose reductase on the oxidative burst in diabetic neutrophils.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Female; Foot Ulcer; Glucose; Glycated | 1992 |
Comparison of sorbinil and ponalrestat (Statil) diminution of proteinuria in the BB rat.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Ty | 1992 |
The role of aldose reductase inhibition in diabetic neutrophil phagocytosis and killing.
Topics: Adult; Aged; Aldehyde Reductase; Candida albicans; Diabetes Mellitus, Type 1; Female; Glucose; Human | 1991 |
Effect of insulin and statil on aldose reductase expression in diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Blotting, Northern; Body Weight; Diabetes Mellitus, Type | 1991 |
Effect of statil (ICI 128436) on erythrocyte viscosity in vitro.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocytes; Female; Hu | 1988 |