ponalrestat has been researched along with Cataract in 10 studies
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To compare the relative importance of sorbitol dehydrogenase versus aldose reductase inhibition on sugar cataract formation, cataract formation was monitored in 50% galactose-fed and diabetic rats treated with/without the sorbitol dehydrogenase inhibitors SDH-1 or SDH-2 or the aldose reductase inhibitors AL 1576 or Ponalrestat." | 7.70 | Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats. ( Blessing, K; Greentree, W; Inoue, J; Kador, PF; Lackner, PA; Lizak, MJ; Mori, K; Rodriguez, L; Sato, S; Secchi, EF, 1998) |
| " To compare the relative importance of sorbitol dehydrogenase versus aldose reductase inhibition on sugar cataract formation, cataract formation was monitored in 50% galactose-fed and diabetic rats treated with/without the sorbitol dehydrogenase inhibitors SDH-1 or SDH-2 or the aldose reductase inhibitors AL 1576 or Ponalrestat." | 3.70 | Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats. ( Blessing, K; Greentree, W; Inoue, J; Kador, PF; Lackner, PA; Lizak, MJ; Mori, K; Rodriguez, L; Sato, S; Secchi, EF, 1998) |
| "The relative importance of sorbitol formation versus nonenzymatic glycosylation and advanced glycosylation end products (AGEs) on sugar cataract formation was examined in diabetic rats." | 3.70 | Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. ( Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF, 2000) |
| "Experimental galactosemia, induced by feeding rats a galactose enriched diet, reproduces many of the neural and ocular complications of diabetes and induces protein glycation and polyol accumulation." | 1.28 | Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia. ( Daniels, BS; Hostetter, TH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lightman, S | 1 |
| Kador, PF | 4 |
| Inoue, J | 1 |
| Secchi, EF | 1 |
| Lizak, MJ | 1 |
| Rodriguez, L | 1 |
| Mori, K | 1 |
| Greentree, W | 1 |
| Blessing, K | 2 |
| Lackner, PA | 1 |
| Sato, S | 2 |
| Sugiyama, K | 1 |
| Lee, YS | 1 |
| Lee, JW | 1 |
| Fujisawa, S | 1 |
| Lou, MF | 1 |
| Daniels, BS | 1 |
| Hostetter, TH | 1 |
| Mizuno, A | 1 |
| Toshima, S | 1 |
| Mori, Y | 1 |
| Akagi, Y | 1 |
| Ikebe, H | 1 |
| Terubayashi, H | 1 |
| Takahashi, Y | 1 |
| Tsuji, T | 1 |
| Hothersall, JS | 1 |
| Taylaur, CE | 1 |
| McLean, P | 1 |
| Stribling, D | 1 |
| Mirrlees, DJ | 1 |
| Harrison, HE | 1 |
| Earl, DC | 1 |
| Kinoshita, JH | 1 |
| Sharpless, NE | 1 |
2 reviews available for ponalrestat and Cataract
| Article | Year |
|---|---|
Does aldose reductase have a role in the development of the ocular complications of diabetes?
Topics: Aldehyde Reductase; Animals; Cataract; Clinical Trials as Topic; Corneal Diseases; Diabetes Mellitus | 1993 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
8 other studies available for ponalrestat and Cataract
| Article | Year |
|---|---|
Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes | 1998 |
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inh | 1999 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibito | 2000 |
Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia.
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Kidney Glomerulus; Male; Permeability; Phthala | 1991 |
Confirmation of lens hydration by Raman spectroscopy.
Topics: Aldehyde Reductase; Animals; Body Water; Cataract; Diabetes Mellitus, Experimental; Hypoglycemic Age | 1990 |
[Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract].
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Oxazines; Phthalazines; Pyrroles; Rats; Rats, | 1989 |
Antioxidant status in an in vitro model for hyperglycemic lens cataract formation: effect of aldose reductase inhibitor statil.
Topics: Aldehyde Reductase; Animals; Cataract; Glutathione; Hyperglycemia; In Vitro Techniques; Phthalazines | 1988 |
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes; | 1985 |