ponalrestat has been researched along with Cataract, Membranous in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " To compare the relative importance of sorbitol dehydrogenase versus aldose reductase inhibition on sugar cataract formation, cataract formation was monitored in 50% galactose-fed and diabetic rats treated with/without the sorbitol dehydrogenase inhibitors SDH-1 or SDH-2 or the aldose reductase inhibitors AL 1576 or Ponalrestat." | 7.70 | Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats. ( Blessing, K; Greentree, W; Inoue, J; Kador, PF; Lackner, PA; Lizak, MJ; Mori, K; Rodriguez, L; Sato, S; Secchi, EF, 1998) |
| " To compare the relative importance of sorbitol dehydrogenase versus aldose reductase inhibition on sugar cataract formation, cataract formation was monitored in 50% galactose-fed and diabetic rats treated with/without the sorbitol dehydrogenase inhibitors SDH-1 or SDH-2 or the aldose reductase inhibitors AL 1576 or Ponalrestat." | 3.70 | Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats. ( Blessing, K; Greentree, W; Inoue, J; Kador, PF; Lackner, PA; Lizak, MJ; Mori, K; Rodriguez, L; Sato, S; Secchi, EF, 1998) |
| "The relative importance of sorbitol formation versus nonenzymatic glycosylation and advanced glycosylation end products (AGEs) on sugar cataract formation was examined in diabetic rats." | 3.70 | Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. ( Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF, 2000) |
| "Experimental galactosemia, induced by feeding rats a galactose enriched diet, reproduces many of the neural and ocular complications of diabetes and induces protein glycation and polyol accumulation." | 1.28 | Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia. ( Daniels, BS; Hostetter, TH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lightman, S | 1 |
| Kador, PF | 4 |
| Inoue, J | 1 |
| Secchi, EF | 1 |
| Lizak, MJ | 1 |
| Rodriguez, L | 1 |
| Mori, K | 1 |
| Greentree, W | 1 |
| Blessing, K | 2 |
| Lackner, PA | 1 |
| Sato, S | 2 |
| Sugiyama, K | 1 |
| Lee, YS | 1 |
| Lee, JW | 1 |
| Fujisawa, S | 1 |
| Lou, MF | 1 |
| Daniels, BS | 1 |
| Hostetter, TH | 1 |
| Mizuno, A | 1 |
| Toshima, S | 1 |
| Mori, Y | 1 |
| Akagi, Y | 1 |
| Ikebe, H | 1 |
| Terubayashi, H | 1 |
| Takahashi, Y | 1 |
| Tsuji, T | 1 |
| Hothersall, JS | 1 |
| Taylaur, CE | 1 |
| McLean, P | 1 |
| Stribling, D | 1 |
| Mirrlees, DJ | 1 |
| Harrison, HE | 1 |
| Earl, DC | 1 |
| Kinoshita, JH | 1 |
| Sharpless, NE | 1 |
2 reviews available for ponalrestat and Cataract, Membranous
| Article | Year |
|---|---|
Does aldose reductase have a role in the development of the ocular complications of diabetes?
Topics: Aldehyde Reductase; Animals; Cataract; Clinical Trials as Topic; Corneal Diseases; Diabetes Mellitus | 1993 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
8 other studies available for ponalrestat and Cataract, Membranous
| Article | Year |
|---|---|
Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes | 1998 |
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inh | 1999 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibito | 2000 |
Functional and structural alterations of the glomerular permeability barrier in experimental galactosemia.
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Kidney Glomerulus; Male; Permeability; Phthala | 1991 |
Confirmation of lens hydration by Raman spectroscopy.
Topics: Aldehyde Reductase; Animals; Body Water; Cataract; Diabetes Mellitus, Experimental; Hypoglycemic Age | 1990 |
[Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract].
Topics: Aldehyde Reductase; Animals; Cataract; Galactosemias; Oxazines; Phthalazines; Pyrroles; Rats; Rats, | 1989 |
Antioxidant status in an in vitro model for hyperglycemic lens cataract formation: effect of aldose reductase inhibitor statil.
Topics: Aldehyde Reductase; Animals; Cataract; Glutathione; Hyperglycemia; In Vitro Techniques; Phthalazines | 1988 |
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes; | 1985 |