polydatin and Hepatitis-B--Chronic

A hepatitis B virus (HBV) transgenic mice model was used to establish the fatty liver superimposed model by feeding the methionine choline-deficient (MCD) diet for 8 weeks, with or without the gavage of 2 mg/kg zeaxanthin dipalmitate (ZD) three times per week. Both wild-type and HBV transgenic mice, with MCD diet, gained typical non-obese non-alcoholic steatohepatitis (NASH) and HBV symptoms. Coadministration with ZD exhibited evident therapeutic effects through alleviating those pathological events. Moreover, long-term vehicle-ZD treatment was found to be safe. Thus, ZD is a promising and safe hepato-protective agent against hepatic injury induced by superimposed HBV and NASH in non-obese mice.

Topics: Animals; Disease Models, Animal; Hepatitis B virus; Hepatitis B, Chronic; Liver; Lycium; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Structure; Non-alcoholic Fatty Liver Disease; Palmitates; Xanthophylls