poly(sodium-vinyl-sulfonate) and Thrombosis

Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.

Topics: Adsorption; Animals; Antithrombin III; Biocompatible Materials; Blood Coagulation; Blood Proteins; Cells, Cultured; Dogs; Fibroblasts; Heparin; Mice; Partial Thromboplastin Time; Platelet Adhesiveness; Polyurethanes; Polyvinyls; Rabbits; Sulfonic Acids; Surface Properties; Thrombosis