polidocanol and Telangiectasia--Hereditary-Hemorrhagic

Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the most frequent clinical manifestation, leading in many cases to severe impairment of the quality of life in the patients. Though several treatments have been used to reduce epistaxis, none have been completely effective, with the exception of polydocanol (Aethoxysklerol®) in submucosal or subpericondrial injections, which was first presented in 2000 with very good results. After fifteen years using polydocanol in submucosal injections on 45 patients and with nearly 300 injections, we have observed that in 95% of all cases, their nose bleeds improved with respect to frequency and quantity without any important side effects. There was just one case of septal perforation, another with increased septal perforation, and one patient who suffered from dizziness and blurred vision for a few minutes. In this paper the results obtained using this technique over a fifteen-year period will be presented and evaluated.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Epistaxis; Female; Humans; Male; Middle Aged; Polidocanol; Polyethylene Glycols; Sclerosing Solutions; Sclerotherapy; Telangiectasia, Hereditary Hemorrhagic; Young Adult

Topics: Humans; Polidocanol; Polyethylene Glycols; Sclerosing Solutions; Telangiectasia, Hereditary Hemorrhagic

Topics: Adolescent; Adult; Aged; Epistaxis; Female; Hemorrhage; Humans; Male; Middle Aged; Polidocanol; Polyethylene Glycols; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis

In a previous report, we showed the efficacy of the submucous sclerosant therapy with Etoxiesclerol (Polidocanol) in two patients with Rendu-Osler-Weber disease. We confirm, in this present study, the advantages of Etoxiesclerol in the treatment of the epistaxis in the Rendu-Osler disease, in six patients, 3 males and 3 females and likewise in two patients with non-specific granuloma of nasal septum and another patient with cavernous hemangioma of soft palate.

Topics: Adult; Aged; Aged, 80 and over; Female; Granuloma; Hemangioma, Cavernous; Humans; Male; Middle Aged; Palatal Neoplasms; Polidocanol; Polyethylene Glycols; Sclerosing Solutions; Telangiectasia, Hereditary Hemorrhagic